Comparison of effects of cyclosporine 0.05% and 0.1% in dry eye with Sjögren’s syndrome
Abstract Purpose To compare the effects of cyclosporine 0.05% and 0.1% in dry eye with Sjögren’s syndrome. Methods 120 eyes of 60 patients who have been diagnosed with Sjögren’s syndrome were retrospectively enrolled. Thirty patients (group 1, 60 eyes) were treated with cyclosporine 0.1% and 30 pati...
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2025-07-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-025-04173-x |
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| author | Donghyun Jee Su Yeon Han Hyun Seung Kim Eun Chul Kim |
| author_facet | Donghyun Jee Su Yeon Han Hyun Seung Kim Eun Chul Kim |
| author_sort | Donghyun Jee |
| collection | DOAJ |
| description | Abstract Purpose To compare the effects of cyclosporine 0.05% and 0.1% in dry eye with Sjögren’s syndrome. Methods 120 eyes of 60 patients who have been diagnosed with Sjögren’s syndrome were retrospectively enrolled. Thirty patients (group 1, 60 eyes) were treated with cyclosporine 0.1% and 30 patients (group 2, 60 eyes) with cyclosporine 0.05%. Ocular Surface Disease Index Questionnaire (OSDI), Schirmer I test, noninvasive tear break up time (NItBUT), corneal staining score, MMP 9, meibography, meibum quality and expressibility scores, tear meniscus height, and impression cytology were examined before treatment and at 1 and 3 months after treatment. Results All of dry eye signs and symptoms of both groups at 1 and 3 months were significantly improved compared with those before treatment, respectively (P < 0.05). OSDI, Schirmer I test, NItBUT, corneal and conunctival fluorescein score, MMP-9 grade, goblet cell density, and impression cytology grade of group1 were significantly improved compared with group 2 at 1 and 3 months after treatment (P < 0.05). The percentage of discontinued treatment in groups 1 and 2 was 26.7 and 3.3%, respectively. Conclusion Cyclosporine 0.1% was more effective for relieving inflammatory dry eye signs and symptoms but less tolerable compared with cyclosporine 0.05% in dry eye with Sjögren’s syndrome. |
| format | Article |
| id | doaj-art-46f1c1ab3e67497f859fa077fe886edd |
| institution | Kabale University |
| issn | 1471-2415 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj-art-46f1c1ab3e67497f859fa077fe886edd2025-08-20T03:45:23ZengBMCBMC Ophthalmology1471-24152025-07-0125111010.1186/s12886-025-04173-xComparison of effects of cyclosporine 0.05% and 0.1% in dry eye with Sjögren’s syndromeDonghyun Jee0Su Yeon Han1Hyun Seung Kim2Eun Chul Kim3Department of Ophthalmology, St. Vincent’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Ophthalmology, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Ophthalmology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Ophthalmology, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaAbstract Purpose To compare the effects of cyclosporine 0.05% and 0.1% in dry eye with Sjögren’s syndrome. Methods 120 eyes of 60 patients who have been diagnosed with Sjögren’s syndrome were retrospectively enrolled. Thirty patients (group 1, 60 eyes) were treated with cyclosporine 0.1% and 30 patients (group 2, 60 eyes) with cyclosporine 0.05%. Ocular Surface Disease Index Questionnaire (OSDI), Schirmer I test, noninvasive tear break up time (NItBUT), corneal staining score, MMP 9, meibography, meibum quality and expressibility scores, tear meniscus height, and impression cytology were examined before treatment and at 1 and 3 months after treatment. Results All of dry eye signs and symptoms of both groups at 1 and 3 months were significantly improved compared with those before treatment, respectively (P < 0.05). OSDI, Schirmer I test, NItBUT, corneal and conunctival fluorescein score, MMP-9 grade, goblet cell density, and impression cytology grade of group1 were significantly improved compared with group 2 at 1 and 3 months after treatment (P < 0.05). The percentage of discontinued treatment in groups 1 and 2 was 26.7 and 3.3%, respectively. Conclusion Cyclosporine 0.1% was more effective for relieving inflammatory dry eye signs and symptoms but less tolerable compared with cyclosporine 0.05% in dry eye with Sjögren’s syndrome.https://doi.org/10.1186/s12886-025-04173-xCyclosporine 0.05%Cyclosporine 0.1%Sjögren's syndrome |
| spellingShingle | Donghyun Jee Su Yeon Han Hyun Seung Kim Eun Chul Kim Comparison of effects of cyclosporine 0.05% and 0.1% in dry eye with Sjögren’s syndrome BMC Ophthalmology Cyclosporine 0.05% Cyclosporine 0.1% Sjögren's syndrome |
| title | Comparison of effects of cyclosporine 0.05% and 0.1% in dry eye with Sjögren’s syndrome |
| title_full | Comparison of effects of cyclosporine 0.05% and 0.1% in dry eye with Sjögren’s syndrome |
| title_fullStr | Comparison of effects of cyclosporine 0.05% and 0.1% in dry eye with Sjögren’s syndrome |
| title_full_unstemmed | Comparison of effects of cyclosporine 0.05% and 0.1% in dry eye with Sjögren’s syndrome |
| title_short | Comparison of effects of cyclosporine 0.05% and 0.1% in dry eye with Sjögren’s syndrome |
| title_sort | comparison of effects of cyclosporine 0 05 and 0 1 in dry eye with sjogren s syndrome |
| topic | Cyclosporine 0.05% Cyclosporine 0.1% Sjögren's syndrome |
| url | https://doi.org/10.1186/s12886-025-04173-x |
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