The DRN-VLO pathway via distinct 5-HT synaptic mechanisms modulates neuropathic pain–induced depressive-like behaviors in mice

The DRN-VLO pathway via distinct 5-HT synaptic mechanisms modulates neuropathic pain–induced depressive-like behaviors in mice

Abstract Background The neuronal activities within the dorsal raphe nucleus (DRN) and the ventrolateral orbital cortex (VLO) are strongly implicated in the development of depression, a condition comorbid with chronic pain. The goal of the present study was to determine whether and how the DRN-VLO pa...

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Main Authors: Hai-Yan Sheng, Wei-Zhen Liu, Yan-Kai Liu, Qing-Rong Han, Dong-Yang Chen, Li-Bin Zhang, Xin-Ru Chu, Si-Han He, Jia-Xin Li, Zi-Qing Zhang, Bo-Han Duanmu, Ya-Ling Yin, Lin-Hua Jiang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:The Journal of Headache and Pain
Subjects:
Neuropathic pain
Depression
DRN-VLO pathway
5-HT1A/5-HT2A receptors
GABAA receptor
Online Access:https://doi.org/10.1186/s10194-025-02110-3
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