The causal effects between low back pain and cerebrospinal fluid metabolites: a two-sample Mendelian randomization study
Abstract Background Observational studies have shown an association between cerebrospinal fluid (CSF) metabolites and low back pain (LBP), but the causal relationship between these factors remains unclear. Methods We performed a two-sample Mendelian randomization (MR) analysis to examine whether the...
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BMC
2025-02-01
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| Series: | Hereditas |
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| Online Access: | https://doi.org/10.1186/s41065-025-00374-y |
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| author | Run Peng Xiaoxin Wang Wei Wang Zeqin Li Yuze Sun Mingliang Yang |
| author_facet | Run Peng Xiaoxin Wang Wei Wang Zeqin Li Yuze Sun Mingliang Yang |
| author_sort | Run Peng |
| collection | DOAJ |
| description | Abstract Background Observational studies have shown an association between cerebrospinal fluid (CSF) metabolites and low back pain (LBP), but the causal relationship between these factors remains unclear. Methods We performed a two-sample Mendelian randomization (MR) analysis to examine whether there is a causal relationship between CSF metabolites and LBP. We applied several MR methods, including inverse variance weighting, weighted median, MR-Egger, Wald ratio, and MR-PRESSO, to test the causal relationship and conducted a sensitivity analysis to assess the robustness of the results. Results We identified a total of 12 CSF metabolites significantly associated with LBP, of which Bilirubin, 5,6-dihydrothymine, Erythronate, Mannitol/sorbitol, and Butyrate have a potential inhibitory causal effect on LBP risk (p < 0.05). Meanwhile, 2-hydroxyadipate, Gamma-glutamyl-alpha-lysine, Indoleacetate, N-acetylputrescine, Palmitoyl dihydrosphingomyelin, S-methylcysteine, and 2,3-dihydroxy-5-methylthio-4-pentenoate play a causal role in increasing the risk of LBP (p < 0.05). No significant estimates of heterogeneity or pleiotropy were detected. Conclusion Our study emphasizes the causal relationship between CSF metabolites and LBP risk, providing reference for clinical treatment and prognosis of LBP. |
| format | Article |
| id | doaj-art-46e864a7537e46a1a7bd542a4b6c8ac7 |
| institution | Kabale University |
| issn | 1601-5223 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Hereditas |
| spelling | doaj-art-46e864a7537e46a1a7bd542a4b6c8ac72025-02-09T12:40:01ZengBMCHereditas1601-52232025-02-0116211910.1186/s41065-025-00374-yThe causal effects between low back pain and cerebrospinal fluid metabolites: a two-sample Mendelian randomization studyRun Peng0Xiaoxin Wang1Wei Wang2Zeqin Li3Yuze Sun4Mingliang Yang5School of Rehabilitation Medicine, Capital Medical UniversitySchool of Rehabilitation Medicine, Capital Medical UniversitySchool of Rehabilitation Medicine, Capital Medical UniversitySchool of Rehabilitation Medicine, Capital Medical UniversitySchool of Rehabilitation Medicine, Capital Medical UniversitySchool of Rehabilitation Medicine, Capital Medical UniversityAbstract Background Observational studies have shown an association between cerebrospinal fluid (CSF) metabolites and low back pain (LBP), but the causal relationship between these factors remains unclear. Methods We performed a two-sample Mendelian randomization (MR) analysis to examine whether there is a causal relationship between CSF metabolites and LBP. We applied several MR methods, including inverse variance weighting, weighted median, MR-Egger, Wald ratio, and MR-PRESSO, to test the causal relationship and conducted a sensitivity analysis to assess the robustness of the results. Results We identified a total of 12 CSF metabolites significantly associated with LBP, of which Bilirubin, 5,6-dihydrothymine, Erythronate, Mannitol/sorbitol, and Butyrate have a potential inhibitory causal effect on LBP risk (p < 0.05). Meanwhile, 2-hydroxyadipate, Gamma-glutamyl-alpha-lysine, Indoleacetate, N-acetylputrescine, Palmitoyl dihydrosphingomyelin, S-methylcysteine, and 2,3-dihydroxy-5-methylthio-4-pentenoate play a causal role in increasing the risk of LBP (p < 0.05). No significant estimates of heterogeneity or pleiotropy were detected. Conclusion Our study emphasizes the causal relationship between CSF metabolites and LBP risk, providing reference for clinical treatment and prognosis of LBP.https://doi.org/10.1186/s41065-025-00374-yCerebrospinal fluid metabolitesBiomarkersLow back painMendelian randomizationCausal relationship |
| spellingShingle | Run Peng Xiaoxin Wang Wei Wang Zeqin Li Yuze Sun Mingliang Yang The causal effects between low back pain and cerebrospinal fluid metabolites: a two-sample Mendelian randomization study Hereditas Cerebrospinal fluid metabolites Biomarkers Low back pain Mendelian randomization Causal relationship |
| title | The causal effects between low back pain and cerebrospinal fluid metabolites: a two-sample Mendelian randomization study |
| title_full | The causal effects between low back pain and cerebrospinal fluid metabolites: a two-sample Mendelian randomization study |
| title_fullStr | The causal effects between low back pain and cerebrospinal fluid metabolites: a two-sample Mendelian randomization study |
| title_full_unstemmed | The causal effects between low back pain and cerebrospinal fluid metabolites: a two-sample Mendelian randomization study |
| title_short | The causal effects between low back pain and cerebrospinal fluid metabolites: a two-sample Mendelian randomization study |
| title_sort | causal effects between low back pain and cerebrospinal fluid metabolites a two sample mendelian randomization study |
| topic | Cerebrospinal fluid metabolites Biomarkers Low back pain Mendelian randomization Causal relationship |
| url | https://doi.org/10.1186/s41065-025-00374-y |
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