Identification of lactylation-associated immune and metabolic regulators in bladder cancer via integrated bulk and single-cell transcriptomics

Identification of lactylation-associated immune and metabolic regulators in bladder cancer via integrated bulk and single-cell transcriptomics

BackgroundLactate-driven metabolic reprogramming and histone lactylation play pivotal roles in bladder cancer (BLCA) progression, yet their underlying mechanisms and regulatory genes remain poorly understood.MethodsUsing transcriptomic data from The Cancer Genome Atlas (TCGA), we identified lactylat...

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Bibliographic Details
Main Authors: Yanjun Chen, Yu Sun, Xiaoyan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
lactylation
immunological regulators
bladder cancer
single cell
metabolic regulators
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1604758/full
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