cGAMP-targeting injectable hydrogel system promotes periodontal restoration by alleviating cGAS-STING pathway activation

cGAMP-targeting injectable hydrogel system promotes periodontal restoration by alleviating cGAS-STING pathway activation

The impaired function of periodontal ligament stem cells (PDLSCs) impedes restoration of periodontal tissues. The cGAS-cGAMP-STING pathway is an innate immune pathway that sensing cytosolic double-stranded DNA (dsDNA), but its role in regulating the function of PDLSCs is still unclear. In this study...

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Bibliographic Details
Main Authors: Xiang Liu, Hua Zhang, Lei Xu, Huayu Ye, Jinghuan Huang, Jing Xiang, Yunying He, Huan Zhou, Lingli Fang, Yunyan Zhang, Xuerong Xiang, Richard D. Cannon, Ping Ji, Qiming Zhai
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-06-01
Series:Bioactive Materials
Subjects:
cGAMP homeostasis
cGAS-STING pathway
Inflammatory environment
Periodontal ligament stem cells
Osteogenic differentiation
Injectable hydrogel system
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25000593
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