The Influence of Storage Temperature on the Antibiotic Release of Vancomycin-Loaded Polymethylmethacrylate
Periprosthetic joint infection is devastating and increases medical expenditure and socioeconomic burden. Antibiotic-loaded cement spacer is useful in the interim period before the reimplantation surgery. Prefabricated antibiotic-loaded cement spacers can decrease operation time but have been limite...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/573526 |
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| _version_ | 1849405118098702336 |
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| author | Dave W. Chen Yuhan Chang Pang-Hsin Hsieh Steve W. N. Ueng Mel S. Lee |
| author_facet | Dave W. Chen Yuhan Chang Pang-Hsin Hsieh Steve W. N. Ueng Mel S. Lee |
| author_sort | Dave W. Chen |
| collection | DOAJ |
| description | Periprosthetic joint infection is devastating and increases medical expenditure and socioeconomic burden. Antibiotic-loaded cement spacer is useful in the interim period before the reimplantation surgery. Prefabricated antibiotic-loaded cement spacers can decrease operation time but have been limitedly used clinically. In the literature, there is no clear recommendation on the storage temperature for the prefabricated cement spacers. We used an in vitro model to analyze whether the storage temperature at 25°C, 4°C, or −20°C for 2 weeks or 3 months could affect the release of vancomycin from the cement. We found that the storage temperature and time had no significant effects on the pattern and amount of vancomycin release. The patterns of vancomycin release from the cement stored at different temperatures were similar with an abrupt release in the first 3 days and steadily declined in the following period. This study provides a preliminary result to justify the storage of fabricating antibiotic-loaded cement spacer sterilely packed at room temperature. Further studies to examine the effects of storage temperature on the mechanical strength and the release pattern of other antibiotics should be done to provide more evidence to support the clinical use of prefabricated ready-to-use antibiotic-loaded cement spacer. |
| format | Article |
| id | doaj-art-46e0a7b111bc4fe3ab445a781b0e2f99 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-46e0a7b111bc4fe3ab445a781b0e2f992025-08-20T03:36:45ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/573526573526The Influence of Storage Temperature on the Antibiotic Release of Vancomycin-Loaded PolymethylmethacrylateDave W. Chen0Yuhan Chang1Pang-Hsin Hsieh2Steve W. N. Ueng3Mel S. Lee4Department of Orthopaedic Surgery, Linkou Chang Gung Memorial Hospital, TaiwanDepartment of Orthopaedic Surgery, Linkou Chang Gung Memorial Hospital, TaiwanDepartment of Orthopaedic Surgery, Linkou Chang Gung Memorial Hospital, TaiwanDepartment of Orthopaedic Surgery, Linkou Chang Gung Memorial Hospital, TaiwanDepartment of Orthopaedic Surgery, Linkou Chang Gung Memorial Hospital, TaiwanPeriprosthetic joint infection is devastating and increases medical expenditure and socioeconomic burden. Antibiotic-loaded cement spacer is useful in the interim period before the reimplantation surgery. Prefabricated antibiotic-loaded cement spacers can decrease operation time but have been limitedly used clinically. In the literature, there is no clear recommendation on the storage temperature for the prefabricated cement spacers. We used an in vitro model to analyze whether the storage temperature at 25°C, 4°C, or −20°C for 2 weeks or 3 months could affect the release of vancomycin from the cement. We found that the storage temperature and time had no significant effects on the pattern and amount of vancomycin release. The patterns of vancomycin release from the cement stored at different temperatures were similar with an abrupt release in the first 3 days and steadily declined in the following period. This study provides a preliminary result to justify the storage of fabricating antibiotic-loaded cement spacer sterilely packed at room temperature. Further studies to examine the effects of storage temperature on the mechanical strength and the release pattern of other antibiotics should be done to provide more evidence to support the clinical use of prefabricated ready-to-use antibiotic-loaded cement spacer.http://dx.doi.org/10.1155/2013/573526 |
| spellingShingle | Dave W. Chen Yuhan Chang Pang-Hsin Hsieh Steve W. N. Ueng Mel S. Lee The Influence of Storage Temperature on the Antibiotic Release of Vancomycin-Loaded Polymethylmethacrylate The Scientific World Journal |
| title | The Influence of Storage Temperature on the Antibiotic Release of Vancomycin-Loaded Polymethylmethacrylate |
| title_full | The Influence of Storage Temperature on the Antibiotic Release of Vancomycin-Loaded Polymethylmethacrylate |
| title_fullStr | The Influence of Storage Temperature on the Antibiotic Release of Vancomycin-Loaded Polymethylmethacrylate |
| title_full_unstemmed | The Influence of Storage Temperature on the Antibiotic Release of Vancomycin-Loaded Polymethylmethacrylate |
| title_short | The Influence of Storage Temperature on the Antibiotic Release of Vancomycin-Loaded Polymethylmethacrylate |
| title_sort | influence of storage temperature on the antibiotic release of vancomycin loaded polymethylmethacrylate |
| url | http://dx.doi.org/10.1155/2013/573526 |
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