Macrophages and Uveitis in Experimental Animal Models
Resident and infiltrated macrophages play relevant roles in uveitis as effectors of innate immunity and inductors of acquired immunity. They are major effectors of tissue damage in uveitis and are also considered to be potent antigen-presenting cells. In the last few years, experimental animal model...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/671417 |
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| _version_ | 1850110417408360448 |
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| author | Salvador Mérida Elena Palacios Amparo Navea Francisco Bosch-Morell |
| author_facet | Salvador Mérida Elena Palacios Amparo Navea Francisco Bosch-Morell |
| author_sort | Salvador Mérida |
| collection | DOAJ |
| description | Resident and infiltrated macrophages play relevant roles in uveitis as effectors of innate immunity and inductors of acquired immunity. They are major effectors of tissue damage in uveitis and are also considered to be potent antigen-presenting cells. In the last few years, experimental animal models of uveitis have enabled us to enhance our understanding of the leading role of macrophages in eye inflammation processes, including macrophage polarization in experimental autoimmune uveoretinitis and the major role of Toll-like receptor 4 in endotoxin-induced uveitis. This improved knowledge should guide advantageous iterative research to establish mechanisms and possible therapeutic targets for human uveitis resolution. |
| format | Article |
| id | doaj-art-46dade6ce78e4c028097ad18bea6bccc |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-46dade6ce78e4c028097ad18bea6bccc2025-08-20T02:37:50ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/671417671417Macrophages and Uveitis in Experimental Animal ModelsSalvador Mérida0Elena Palacios1Amparo Navea2Francisco Bosch-Morell3Instituto de Ciencias Biomédicas, Universidad CEU Cardenal Herrera, 46113 Valencia, SpainFISABIO, Oftalmología Médica, 46020 Valencia, SpainInstituto de Ciencias Biomédicas, Universidad CEU Cardenal Herrera, 46113 Valencia, SpainInstituto de Ciencias Biomédicas, Universidad CEU Cardenal Herrera, 46113 Valencia, SpainResident and infiltrated macrophages play relevant roles in uveitis as effectors of innate immunity and inductors of acquired immunity. They are major effectors of tissue damage in uveitis and are also considered to be potent antigen-presenting cells. In the last few years, experimental animal models of uveitis have enabled us to enhance our understanding of the leading role of macrophages in eye inflammation processes, including macrophage polarization in experimental autoimmune uveoretinitis and the major role of Toll-like receptor 4 in endotoxin-induced uveitis. This improved knowledge should guide advantageous iterative research to establish mechanisms and possible therapeutic targets for human uveitis resolution.http://dx.doi.org/10.1155/2015/671417 |
| spellingShingle | Salvador Mérida Elena Palacios Amparo Navea Francisco Bosch-Morell Macrophages and Uveitis in Experimental Animal Models Mediators of Inflammation |
| title | Macrophages and Uveitis in Experimental Animal Models |
| title_full | Macrophages and Uveitis in Experimental Animal Models |
| title_fullStr | Macrophages and Uveitis in Experimental Animal Models |
| title_full_unstemmed | Macrophages and Uveitis in Experimental Animal Models |
| title_short | Macrophages and Uveitis in Experimental Animal Models |
| title_sort | macrophages and uveitis in experimental animal models |
| url | http://dx.doi.org/10.1155/2015/671417 |
| work_keys_str_mv | AT salvadormerida macrophagesanduveitisinexperimentalanimalmodels AT elenapalacios macrophagesanduveitisinexperimentalanimalmodels AT amparonavea macrophagesanduveitisinexperimentalanimalmodels AT franciscoboschmorell macrophagesanduveitisinexperimentalanimalmodels |