New semiquantitative parameters in digital [18F]FDG PET/CT improve diagnostic accuracy in suspected infective endocarditis
Abstract Background The purpose of this study was to identify semiquantitative parameters of [18F]FDG PET/CT using a digital PET scanner, which may increase diagnostic accuracy and readers’ confidence in the diagnosis of infective endocarditis (IE). Results Images of 82 patients undergoing [18F]FDG...
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| Language: | English |
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Springer
2025-06-01
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| Series: | EJNMMI Reports |
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| Online Access: | https://doi.org/10.1186/s41824-025-00256-6 |
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| author | Carola Maria Bregenzer Luisa Maria Knappe Alexander Weissensee Nasir Gözlügöl Ali Afshar-Oromieh Clemens Mingels Christoph Gräni Axel Rominger Federico Caobelli |
| author_facet | Carola Maria Bregenzer Luisa Maria Knappe Alexander Weissensee Nasir Gözlügöl Ali Afshar-Oromieh Clemens Mingels Christoph Gräni Axel Rominger Federico Caobelli |
| author_sort | Carola Maria Bregenzer |
| collection | DOAJ |
| description | Abstract Background The purpose of this study was to identify semiquantitative parameters of [18F]FDG PET/CT using a digital PET scanner, which may increase diagnostic accuracy and readers’ confidence in the diagnosis of infective endocarditis (IE). Results Images of 82 patients undergoing [18F]FDG PET/CT for suspected IE were visually and semiquantitatively analyzed. Standardized uptake values (SUV) of suspected foci, also normalized to liver, mediastinum and surrounding activity were calculated. For each, best thresholds were identified to diagnose endocarditis. Final diagnosis was reached by consensus in a multidisciplinary board. Semiquantitative analysis (SUVmax/SUVmax mediastinum, SUVmax/SUVmax liver, SUVpeak/SUVpeak mediastinum, SUVpeak/SUVpeak liver, SUVmax/SUVmean liver, SUVmax/SUVmean mediastinum, SUVmax focus/SUVmean focus, SUVpeak/SUVpeak surrounding) added to visual interpretation increased sensitivity (57–86%), specificity (83–93%), PPV (64–86%), NPV (79–93%) and diagnostic accuracy (74–90%) when using best SUVs thresholds (all p < 0.05). Conclusions Combining visual and semiquantitative analysis allows for a more accurate diagnosis of IE, and might be implemented into clinical routine. |
| format | Article |
| id | doaj-art-46d9e94a1e4b44ceb87e248f25e95702 |
| institution | Kabale University |
| issn | 3005-074X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Springer |
| record_format | Article |
| series | EJNMMI Reports |
| spelling | doaj-art-46d9e94a1e4b44ceb87e248f25e957022025-08-20T03:31:45ZengSpringerEJNMMI Reports3005-074X2025-06-019111010.1186/s41824-025-00256-6New semiquantitative parameters in digital [18F]FDG PET/CT improve diagnostic accuracy in suspected infective endocarditisCarola Maria Bregenzer0Luisa Maria Knappe1Alexander Weissensee2Nasir Gözlügöl3Ali Afshar-Oromieh4Clemens Mingels5Christoph Gräni6Axel Rominger7Federico Caobelli8Department of Nuclear Medicine, Bern University Hospital, Inselspital, University of BernDepartment of Nuclear Medicine, Bern University Hospital, Inselspital, University of BernDepartment of Nuclear Medicine, Bern University Hospital, Inselspital, University of BernDepartment of Nuclear Medicine, Bern University Hospital, Inselspital, University of BernDepartment of Nuclear Medicine, Bern University Hospital, Inselspital, University of BernDepartment of Nuclear Medicine, Bern University Hospital, Inselspital, University of BernDepartment of Cardiology, University Hospital Bern, Inselspital, University of BernDepartment of Nuclear Medicine, Bern University Hospital, Inselspital, University of BernDepartment of Nuclear Medicine, Bern University Hospital, Inselspital, University of BernAbstract Background The purpose of this study was to identify semiquantitative parameters of [18F]FDG PET/CT using a digital PET scanner, which may increase diagnostic accuracy and readers’ confidence in the diagnosis of infective endocarditis (IE). Results Images of 82 patients undergoing [18F]FDG PET/CT for suspected IE were visually and semiquantitatively analyzed. Standardized uptake values (SUV) of suspected foci, also normalized to liver, mediastinum and surrounding activity were calculated. For each, best thresholds were identified to diagnose endocarditis. Final diagnosis was reached by consensus in a multidisciplinary board. Semiquantitative analysis (SUVmax/SUVmax mediastinum, SUVmax/SUVmax liver, SUVpeak/SUVpeak mediastinum, SUVpeak/SUVpeak liver, SUVmax/SUVmean liver, SUVmax/SUVmean mediastinum, SUVmax focus/SUVmean focus, SUVpeak/SUVpeak surrounding) added to visual interpretation increased sensitivity (57–86%), specificity (83–93%), PPV (64–86%), NPV (79–93%) and diagnostic accuracy (74–90%) when using best SUVs thresholds (all p < 0.05). Conclusions Combining visual and semiquantitative analysis allows for a more accurate diagnosis of IE, and might be implemented into clinical routine.https://doi.org/10.1186/s41824-025-00256-6Infective endocarditisPET/CTInfectionSemiquantitative parameters |
| spellingShingle | Carola Maria Bregenzer Luisa Maria Knappe Alexander Weissensee Nasir Gözlügöl Ali Afshar-Oromieh Clemens Mingels Christoph Gräni Axel Rominger Federico Caobelli New semiquantitative parameters in digital [18F]FDG PET/CT improve diagnostic accuracy in suspected infective endocarditis EJNMMI Reports Infective endocarditis PET/CT Infection Semiquantitative parameters |
| title | New semiquantitative parameters in digital [18F]FDG PET/CT improve diagnostic accuracy in suspected infective endocarditis |
| title_full | New semiquantitative parameters in digital [18F]FDG PET/CT improve diagnostic accuracy in suspected infective endocarditis |
| title_fullStr | New semiquantitative parameters in digital [18F]FDG PET/CT improve diagnostic accuracy in suspected infective endocarditis |
| title_full_unstemmed | New semiquantitative parameters in digital [18F]FDG PET/CT improve diagnostic accuracy in suspected infective endocarditis |
| title_short | New semiquantitative parameters in digital [18F]FDG PET/CT improve diagnostic accuracy in suspected infective endocarditis |
| title_sort | new semiquantitative parameters in digital 18f fdg pet ct improve diagnostic accuracy in suspected infective endocarditis |
| topic | Infective endocarditis PET/CT Infection Semiquantitative parameters |
| url | https://doi.org/10.1186/s41824-025-00256-6 |
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