Heparanase 2 Modulation Inhibits HSV-2 Replication by Regulating Heparan Sulfate

Heparanase 2 Modulation Inhibits HSV-2 Replication by Regulating Heparan Sulfate

The host enzyme heparanase (HPSE) facilitates the release of herpes simplex virus type 2 (HSV-2) from target cells by cleaving the viral attachment receptor heparan sulfate (HS) from infected cell surfaces. HPSE 2, an isoform of HPSE, binds to but does not possess the enzymatic activity needed to cl...

Full description

Saved in:
Bibliographic Details
Main Authors: James Hopkins, Ipsita Volety, Farreh Qatanani, Deepak Shukla
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Viruses
Subjects:
heparanase 2
herpes simplex virus type 2
heparan sulfate
Online Access:https://www.mdpi.com/1999-4915/16/12/1832
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items