Cancer-specific senescence signature promotes malignant phenotypes and immunotherapy resistance in colorectal cancer

Cancer-specific senescence signature promotes malignant phenotypes and immunotherapy resistance in colorectal cancer

BackgroundWhile cellular senescence in colorectal cancer (CRC) exhibits strong correlations with immunotherapy response and clinical prognosis, its mechanistic basis remains elusive, and validated predictive biomarkers are currently unavailable.MethodsIn this study, we integrated single-cell and bul...

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Bibliographic Details
Main Authors: Wei Wang, Fengyu Ling, Dong Huang, Guomin Luo, Bixia Duan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
colorectal cancer
immunotherapy resistance
senescence
prognosis
tumor immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1603787/full
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