Cryosurgical and cryoradiation treatments in patients with calvarial skin cancer
The authors developed a novel cryoradiation treatment in patients with locally advanced basal cell and squamous cell carcinoma of the head skin, which included a combination of tumor cryogenic and radiation exposures. of a tumor. Immediately before each radiotherapy session, local tumor cooling is c...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2015-11-01
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| Series: | Опухоли головы и шеи |
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| Online Access: | https://ogsh.abvpress.ru/jour/article/view/168 |
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| author | I. N. Pustynskiy S. I. Tkachev T. D. Tabolinovskaya S. B. Alieva |
| author_facet | I. N. Pustynskiy S. I. Tkachev T. D. Tabolinovskaya S. B. Alieva |
| author_sort | I. N. Pustynskiy |
| collection | DOAJ |
| description | The authors developed a novel cryoradiation treatment in patients with locally advanced basal cell and squamous cell carcinoma of the head skin, which included a combination of tumor cryogenic and radiation exposures. of a tumor. Immediately before each radiotherapy session, local tumor cooling is carried out until the freezing temperature is achieved at the tumor-intact tissue border. Irradiation is performed in cycles: at a single daily focal dose of 2.0–2.5 Gy during 5 days at a 2-day interval until the cumulative focal dose of 60–70 Gy is achieved. The results of cryosurgical and cryoradiation treatments were investigated in 112 patients with basal cell (n = 101) and squamous cell (n = 11) carcinoma of the calvarial skin. Among the patients, there were 48 (42.9 %) men and 64 (57.1 %) women; their mean age was 67.1 (39–107) years. The skin tumor was located in the parietal region in 30 (26.8 %) patients, in the temporal region in 55 (49.1 %), in the frontal region in 26 (23.2 %), and in occipital region in 1. The size of the neoplasms in all the patients was more than 1 cm; the tumors belonged to a high recurrence risk group. The method of treatment was chosen according to indicators. The postoperative follow-ups of the patients were 2 to 14 years (median follow-up, 7 years). Recurrences of skin cancer were diagnosed in 5 (4.5 %) of the 18 patients: 1 (1 %) after treatment for its primary forms and 4 (22.2 %) after that of recurrences. Cryosurgical and cryoradiation treatments performed as clinically indicated could yield good functional, aesthetic, and long-term results and ensure effective rehabilitation in patients after the treatment conducted. |
| format | Article |
| id | doaj-art-46d5fee7fb3f4ef1ab65aea5e5b09c00 |
| institution | Kabale University |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| publishDate | 2015-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj-art-46d5fee7fb3f4ef1ab65aea5e5b09c002025-08-20T04:00:26ZrusABV-pressОпухоли головы и шеи2222-14682411-46342015-11-0153243010.17650/2222-1468-2015-5-3-24-30160Cryosurgical and cryoradiation treatments in patients with calvarial skin cancerI. N. Pustynskiy0S. I. Tkachev1T. D. Tabolinovskaya2S. B. Alieva3N. N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 23 Kashirskoe Shosse, Moscow, 115478, RussiaN. N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 23 Kashirskoe Shosse, Moscow, 115478, RussiaN. N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 23 Kashirskoe Shosse, Moscow, 115478, RussiaN. N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 23 Kashirskoe Shosse, Moscow, 115478, RussiaThe authors developed a novel cryoradiation treatment in patients with locally advanced basal cell and squamous cell carcinoma of the head skin, which included a combination of tumor cryogenic and radiation exposures. of a tumor. Immediately before each radiotherapy session, local tumor cooling is carried out until the freezing temperature is achieved at the tumor-intact tissue border. Irradiation is performed in cycles: at a single daily focal dose of 2.0–2.5 Gy during 5 days at a 2-day interval until the cumulative focal dose of 60–70 Gy is achieved. The results of cryosurgical and cryoradiation treatments were investigated in 112 patients with basal cell (n = 101) and squamous cell (n = 11) carcinoma of the calvarial skin. Among the patients, there were 48 (42.9 %) men and 64 (57.1 %) women; their mean age was 67.1 (39–107) years. The skin tumor was located in the parietal region in 30 (26.8 %) patients, in the temporal region in 55 (49.1 %), in the frontal region in 26 (23.2 %), and in occipital region in 1. The size of the neoplasms in all the patients was more than 1 cm; the tumors belonged to a high recurrence risk group. The method of treatment was chosen according to indicators. The postoperative follow-ups of the patients were 2 to 14 years (median follow-up, 7 years). Recurrences of skin cancer were diagnosed in 5 (4.5 %) of the 18 patients: 1 (1 %) after treatment for its primary forms and 4 (22.2 %) after that of recurrences. Cryosurgical and cryoradiation treatments performed as clinically indicated could yield good functional, aesthetic, and long-term results and ensure effective rehabilitation in patients after the treatment conducted.https://ogsh.abvpress.ru/jour/article/view/168basal cell carcinomasquamous cell carcinomacalvariumcryodestructoncryoradiation treatmentcryosurgical treatmentradiotherapyrecurrencelong-term resultsrehabilitation |
| spellingShingle | I. N. Pustynskiy S. I. Tkachev T. D. Tabolinovskaya S. B. Alieva Cryosurgical and cryoradiation treatments in patients with calvarial skin cancer Опухоли головы и шеи basal cell carcinoma squamous cell carcinoma calvarium cryodestructon cryoradiation treatment cryosurgical treatment radiotherapy recurrence long-term results rehabilitation |
| title | Cryosurgical and cryoradiation treatments in patients with calvarial skin cancer |
| title_full | Cryosurgical and cryoradiation treatments in patients with calvarial skin cancer |
| title_fullStr | Cryosurgical and cryoradiation treatments in patients with calvarial skin cancer |
| title_full_unstemmed | Cryosurgical and cryoradiation treatments in patients with calvarial skin cancer |
| title_short | Cryosurgical and cryoradiation treatments in patients with calvarial skin cancer |
| title_sort | cryosurgical and cryoradiation treatments in patients with calvarial skin cancer |
| topic | basal cell carcinoma squamous cell carcinoma calvarium cryodestructon cryoradiation treatment cryosurgical treatment radiotherapy recurrence long-term results rehabilitation |
| url | https://ogsh.abvpress.ru/jour/article/view/168 |
| work_keys_str_mv | AT inpustynskiy cryosurgicalandcryoradiationtreatmentsinpatientswithcalvarialskincancer AT sitkachev cryosurgicalandcryoradiationtreatmentsinpatientswithcalvarialskincancer AT tdtabolinovskaya cryosurgicalandcryoradiationtreatmentsinpatientswithcalvarialskincancer AT sbalieva cryosurgicalandcryoradiationtreatmentsinpatientswithcalvarialskincancer |