Cardiorenal protective effects of Tanhuo decoction in acute myocardial infarction via regulating multi-target inflammation and metabolic signaling pathways
IntroductionInflammation is a key driver of adverse outcomes in acute myocardial infarction (AMI), yet current western anti-inflammatory therapies are limited by their single-target nature and side effects. Traditional Chinese medicine (TCM), such as Tanhuo Decoction (THD), offers a multi-target, lo...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1555605/full |
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| author | Chenglong Guo Tianxing Zhang Lingqian He Minyu Zhang Yanyan Chu Xipeng Sun Xuexue Han Yijiang Liu Juexian Song Jinggang Xia |
| author_facet | Chenglong Guo Tianxing Zhang Lingqian He Minyu Zhang Yanyan Chu Xipeng Sun Xuexue Han Yijiang Liu Juexian Song Jinggang Xia |
| author_sort | Chenglong Guo |
| collection | DOAJ |
| description | IntroductionInflammation is a key driver of adverse outcomes in acute myocardial infarction (AMI), yet current western anti-inflammatory therapies are limited by their single-target nature and side effects. Traditional Chinese medicine (TCM), such as Tanhuo Decoction (THD), offers a multi-target, low-toxicity alternative.MethodsIn a randomized controlled trial, AMI patients with high inflammatory responses received either standard Western medicine (WM) alone or combined with THD for 3 days. Clinical outcomes and inflammatory markers were assessed, and proteomic and network pharmacology analyses were performed.ResultsThe THD + WM group showed significant reductions in neutrophil counts and hs-CRP levels, along with improved creatinine clearance rate (CCR), compared to WM alone. Proteomic analysis revealed downregulation of pro-inflammatory proteins (PTX3, IL-18, TNFRSF11A) and upregulation of the anti-inflammatory IL1RL2. THD also modulated lipid metabolism and insulin sensitivity pathways.DiscussionsTHD enhances the anti-inflammatory and metabolic benefits of standard AMI therapy through multi-target pathway regulation. These findings support its integration into modern cardiovascular care, particularly for patients with high inflammatory and metabolic risk. |
| format | Article |
| id | doaj-art-46d522ef09db43589a137f0d049d59a4 |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-46d522ef09db43589a137f0d049d59a42025-08-20T03:03:45ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-03-011610.3389/fphar.2025.15556051555605Cardiorenal protective effects of Tanhuo decoction in acute myocardial infarction via regulating multi-target inflammation and metabolic signaling pathwaysChenglong Guo0Tianxing Zhang1Lingqian He2Minyu Zhang3Yanyan Chu4Xipeng Sun5Xuexue Han6Yijiang Liu7Juexian Song8Jinggang Xia9Pulmonary Vascular Disease Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaSchool of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaSenior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaIntroductionInflammation is a key driver of adverse outcomes in acute myocardial infarction (AMI), yet current western anti-inflammatory therapies are limited by their single-target nature and side effects. Traditional Chinese medicine (TCM), such as Tanhuo Decoction (THD), offers a multi-target, low-toxicity alternative.MethodsIn a randomized controlled trial, AMI patients with high inflammatory responses received either standard Western medicine (WM) alone or combined with THD for 3 days. Clinical outcomes and inflammatory markers were assessed, and proteomic and network pharmacology analyses were performed.ResultsThe THD + WM group showed significant reductions in neutrophil counts and hs-CRP levels, along with improved creatinine clearance rate (CCR), compared to WM alone. Proteomic analysis revealed downregulation of pro-inflammatory proteins (PTX3, IL-18, TNFRSF11A) and upregulation of the anti-inflammatory IL1RL2. THD also modulated lipid metabolism and insulin sensitivity pathways.DiscussionsTHD enhances the anti-inflammatory and metabolic benefits of standard AMI therapy through multi-target pathway regulation. These findings support its integration into modern cardiovascular care, particularly for patients with high inflammatory and metabolic risk.https://www.frontiersin.org/articles/10.3389/fphar.2025.1555605/fullacute myocardial infarctionTanhuo decoctioncardiorenal protectioninflammationmetabolism |
| spellingShingle | Chenglong Guo Tianxing Zhang Lingqian He Minyu Zhang Yanyan Chu Xipeng Sun Xuexue Han Yijiang Liu Juexian Song Jinggang Xia Cardiorenal protective effects of Tanhuo decoction in acute myocardial infarction via regulating multi-target inflammation and metabolic signaling pathways Frontiers in Pharmacology acute myocardial infarction Tanhuo decoction cardiorenal protection inflammation metabolism |
| title | Cardiorenal protective effects of Tanhuo decoction in acute myocardial infarction via regulating multi-target inflammation and metabolic signaling pathways |
| title_full | Cardiorenal protective effects of Tanhuo decoction in acute myocardial infarction via regulating multi-target inflammation and metabolic signaling pathways |
| title_fullStr | Cardiorenal protective effects of Tanhuo decoction in acute myocardial infarction via regulating multi-target inflammation and metabolic signaling pathways |
| title_full_unstemmed | Cardiorenal protective effects of Tanhuo decoction in acute myocardial infarction via regulating multi-target inflammation and metabolic signaling pathways |
| title_short | Cardiorenal protective effects of Tanhuo decoction in acute myocardial infarction via regulating multi-target inflammation and metabolic signaling pathways |
| title_sort | cardiorenal protective effects of tanhuo decoction in acute myocardial infarction via regulating multi target inflammation and metabolic signaling pathways |
| topic | acute myocardial infarction Tanhuo decoction cardiorenal protection inflammation metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1555605/full |
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