Intracellular Formation of Synthetic Peptide Nanostructures Causes Mitochondrial Disruption and Cell Death in Tumor Spheroids

Intracellular Formation of Synthetic Peptide Nanostructures Causes Mitochondrial Disruption and Cell Death in Tumor Spheroids

Abstract Supramolecular assemblies found in nature demonstrate the concept of creating functionality through structure formation. In recent years, these complex natural architectures have inspired the development of materials for the formation of synthetic nanostructures within living cells. These i...

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Bibliographic Details
Main Authors: Sarah Chagri, Konrad Maxeiner, Maria J. S. A. Silva, Lisa Förch, Julian Link, Patrick Roth, Raphael Meyer, Jana Fetzer, Anke Kaltbeitzel, Ingo Lieberwirth, Katharina Landfester, Manfred Wagner, David Y.W. Ng, Tanja Weil
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
bioresponsive nanomaterials
mitochondrial disruption
peptide nanostructures
supramolecular assemblies
synthetic intracellular nanostructures
tumor spheroids
Online Access:https://doi.org/10.1002/advs.202412606
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