Epidemiology and risk factors of glaucoma in a comprehensive health screening baseline report from the Gangnam Eye Cohort Study
Abstract We investigated the epidemiology and systemic risk factors of glaucoma in a health screening center-based cohort. The Gangnam Eye Cohort Study included 75,154 participants who completed initial comprehensive health check-up examinations in 2003–2010. In this baseline report, the prevalence...
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Nature Portfolio
2025-07-01
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| author | Eunoo Bak Jin-Soo Kim Dae Joong Ma Jinho Lee Baek Lok Oh Ahnul Ha Hyuk Jin Choi |
| author_facet | Eunoo Bak Jin-Soo Kim Dae Joong Ma Jinho Lee Baek Lok Oh Ahnul Ha Hyuk Jin Choi |
| author_sort | Eunoo Bak |
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| description | Abstract We investigated the epidemiology and systemic risk factors of glaucoma in a health screening center-based cohort. The Gangnam Eye Cohort Study included 75,154 participants who completed initial comprehensive health check-up examinations in 2003–2010. In this baseline report, the prevalence of glaucoma was estimated, ocular and systemic factors were compared between glaucoma and normal control groups, and risk factors were analyzed by logistic regression. The prevalence of glaucoma was 2.8%; 3.4% in men and 2.1% in women, and increased with age (P < 0.001). Mean age of the glaucoma group (52.8 ± 10.9 years) was older than that of the normal group (48.1 ± 10.3 years, P < 0.001). Mean intraocular pressure (IOP) of the glaucoma group (14.6 ± 3.1 mmHg) was higher than that of the normal group (13.2 ± 2.5 mmHg, P < 0.001). Older age (P < 0.001), male sex (P < 0.001), presence of retinal arteriosclerosis (P < 0.001), higher IOP (P < 0.001), higher household income (P = 0.045), higher education (P < 0.001), overweight status (P = 0.001), higher serum creatinine (P = 0.013) and uric acid (P = 0.008) were significantly associated with glaucoma. In this largest health screening center-based cohort study, considering the associations of glaucoma with retinal microvascular abnormality, obesity, and serum creatinine and uric acid, a common pathway such as arteriosclerosis or oxidative stress may be the vascular problem underlying glaucoma. |
| format | Article |
| id | doaj-art-46d0693a43684b9fb96573da10e9c2fd |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-07-01 |
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| spelling | doaj-art-46d0693a43684b9fb96573da10e9c2fd2025-08-20T03:45:53ZengNature PortfolioScientific Reports2045-23222025-07-0115111010.1038/s41598-025-03939-zEpidemiology and risk factors of glaucoma in a comprehensive health screening baseline report from the Gangnam Eye Cohort StudyEunoo Bak0Jin-Soo Kim1Dae Joong Ma2Jinho Lee3Baek Lok Oh4Ahnul Ha5Hyuk Jin Choi6Department of Ophthalmology, Seoul National University College of MedicineDepartment of Ophthalmology, Seoul National University College of MedicineDepartment of Ophthalmology, Seoul National University College of MedicineDepartment of Ophthalmology, Seoul National University College of MedicineDepartment of Ophthalmology, Seoul National University College of MedicineDepartment of Ophthalmology, Seoul National University College of MedicineDepartment of Ophthalmology, Seoul National University College of MedicineAbstract We investigated the epidemiology and systemic risk factors of glaucoma in a health screening center-based cohort. The Gangnam Eye Cohort Study included 75,154 participants who completed initial comprehensive health check-up examinations in 2003–2010. In this baseline report, the prevalence of glaucoma was estimated, ocular and systemic factors were compared between glaucoma and normal control groups, and risk factors were analyzed by logistic regression. The prevalence of glaucoma was 2.8%; 3.4% in men and 2.1% in women, and increased with age (P < 0.001). Mean age of the glaucoma group (52.8 ± 10.9 years) was older than that of the normal group (48.1 ± 10.3 years, P < 0.001). Mean intraocular pressure (IOP) of the glaucoma group (14.6 ± 3.1 mmHg) was higher than that of the normal group (13.2 ± 2.5 mmHg, P < 0.001). Older age (P < 0.001), male sex (P < 0.001), presence of retinal arteriosclerosis (P < 0.001), higher IOP (P < 0.001), higher household income (P = 0.045), higher education (P < 0.001), overweight status (P = 0.001), higher serum creatinine (P = 0.013) and uric acid (P = 0.008) were significantly associated with glaucoma. In this largest health screening center-based cohort study, considering the associations of glaucoma with retinal microvascular abnormality, obesity, and serum creatinine and uric acid, a common pathway such as arteriosclerosis or oxidative stress may be the vascular problem underlying glaucoma.https://doi.org/10.1038/s41598-025-03939-zComprehensive health screeningEpidemiologyRisk factorGlaucoma |
| spellingShingle | Eunoo Bak Jin-Soo Kim Dae Joong Ma Jinho Lee Baek Lok Oh Ahnul Ha Hyuk Jin Choi Epidemiology and risk factors of glaucoma in a comprehensive health screening baseline report from the Gangnam Eye Cohort Study Scientific Reports Comprehensive health screening Epidemiology Risk factor Glaucoma |
| title | Epidemiology and risk factors of glaucoma in a comprehensive health screening baseline report from the Gangnam Eye Cohort Study |
| title_full | Epidemiology and risk factors of glaucoma in a comprehensive health screening baseline report from the Gangnam Eye Cohort Study |
| title_fullStr | Epidemiology and risk factors of glaucoma in a comprehensive health screening baseline report from the Gangnam Eye Cohort Study |
| title_full_unstemmed | Epidemiology and risk factors of glaucoma in a comprehensive health screening baseline report from the Gangnam Eye Cohort Study |
| title_short | Epidemiology and risk factors of glaucoma in a comprehensive health screening baseline report from the Gangnam Eye Cohort Study |
| title_sort | epidemiology and risk factors of glaucoma in a comprehensive health screening baseline report from the gangnam eye cohort study |
| topic | Comprehensive health screening Epidemiology Risk factor Glaucoma |
| url | https://doi.org/10.1038/s41598-025-03939-z |
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