Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis Dos signos de Babinski en pacientes con paraparesia espástica tropical seropositiva (HAM) y seronegativa
Tropical spastic paraparesis (TSP) may or may not be associated to HTLV-I antibodies and is usually characterized by clinical and pathological spinal cord abnormalities at thoracic levels. We present here five Brazilian patients who had typical chronic idiopatic spastic paraparesis; two of them were...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Revinter Publicações
2008-01-01
|
| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000500016 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850110416259121152 |
|---|---|
| author | Fidias E. Leon-Sarmiento Andres Calderon Hernan G. Hernandez |
| author_facet | Fidias E. Leon-Sarmiento Andres Calderon Hernan G. Hernandez |
| author_sort | Fidias E. Leon-Sarmiento |
| collection | DOAJ |
| description | Tropical spastic paraparesis (TSP) may or may not be associated to HTLV-I antibodies and is usually characterized by clinical and pathological spinal cord abnormalities at thoracic levels. We present here five Brazilian patients who had typical chronic idiopatic spastic paraparesis; two of them were HTLV-I seropositive (HAM) and three HTLV-I seronegative (TSP) - associated-myelopathy. Three out of these five patients also displayed clinical supraspinal involvement, indeed, platysma muscle hypotrophy or atrophy (the Babinski plus sign). These findings support the view that clinical involvement in HAM and TSP is wider than the spinal cord abnormalities usually considered. Possible non-infectious co-factors (e.g., mycotoxins) may be involved in disease pathogenesis in a multistep process of viruses, toxins and environment which may account for serological differences found in this group of patients.<br>La paraparesia espástica tropical (PET), puede o no estar asociada con anticuerpos contra el HTLV-I y se caracteriza, usualmente, por alteraciones clínicas y patológicas a nivel de region dorso-lumbar de la medula espinal. Presentamos cinco pacientes brasileros, quienes tuvieron hallazgos típicos de paraparesia espástica crónica idiopática; dos de ellos tuvieron (HAM) y tres no tuvieron (TSP) anticuerpos, en el suero, contra el HTLV-I. En tres pacientes se encontró hipotrofia o atrofia del músculo platisma (signo de Babinski plus), demostrando que el compromiso clínico en pacientes con HAM y TSP se extiende más allá de la médula espinal torácica. Cofactores (por ejemplo, micotoxinas) podrían estar involucrados en la patogénesis de esta enfermedad, en una interacción compleja de virus, toxinas y medio ambiente, lo cual explicaría las diferencias serológicas encontradas en este grupo de pacientes. |
| format | Article |
| id | doaj-art-46cfcb20487541dda81004d05823d6e1 |
| institution | OA Journals |
| issn | 0004-282X 1678-4227 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-46cfcb20487541dda81004d05823d6e12025-08-20T02:37:50ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria0004-282X1678-42272008-01-01663b69569710.1590/S0004-282X2008000500016Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis Dos signos de Babinski en pacientes con paraparesia espástica tropical seropositiva (HAM) y seronegativaFidias E. Leon-SarmientoAndres CalderonHernan G. HernandezTropical spastic paraparesis (TSP) may or may not be associated to HTLV-I antibodies and is usually characterized by clinical and pathological spinal cord abnormalities at thoracic levels. We present here five Brazilian patients who had typical chronic idiopatic spastic paraparesis; two of them were HTLV-I seropositive (HAM) and three HTLV-I seronegative (TSP) - associated-myelopathy. Three out of these five patients also displayed clinical supraspinal involvement, indeed, platysma muscle hypotrophy or atrophy (the Babinski plus sign). These findings support the view that clinical involvement in HAM and TSP is wider than the spinal cord abnormalities usually considered. Possible non-infectious co-factors (e.g., mycotoxins) may be involved in disease pathogenesis in a multistep process of viruses, toxins and environment which may account for serological differences found in this group of patients.<br>La paraparesia espástica tropical (PET), puede o no estar asociada con anticuerpos contra el HTLV-I y se caracteriza, usualmente, por alteraciones clínicas y patológicas a nivel de region dorso-lumbar de la medula espinal. Presentamos cinco pacientes brasileros, quienes tuvieron hallazgos típicos de paraparesia espástica crónica idiopática; dos de ellos tuvieron (HAM) y tres no tuvieron (TSP) anticuerpos, en el suero, contra el HTLV-I. En tres pacientes se encontró hipotrofia o atrofia del músculo platisma (signo de Babinski plus), demostrando que el compromiso clínico en pacientes con HAM y TSP se extiende más allá de la médula espinal torácica. Cofactores (por ejemplo, micotoxinas) podrían estar involucrados en la patogénesis de esta enfermedad, en una interacción compleja de virus, toxinas y medio ambiente, lo cual explicaría las diferencias serológicas encontradas en este grupo de pacientes.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000500016HAMTSPsigno de Babinski plusneurorehabilitaciónHAMTSPBabinski plus signmycotoxinsneurorehabilitation |
| spellingShingle | Fidias E. Leon-Sarmiento Andres Calderon Hernan G. Hernandez Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis Dos signos de Babinski en pacientes con paraparesia espástica tropical seropositiva (HAM) y seronegativa Arquivos de Neuro-Psiquiatria HAM TSP signo de Babinski plus neurorehabilitación HAM TSP Babinski plus sign mycotoxins neurorehabilitation |
| title | Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis Dos signos de Babinski en pacientes con paraparesia espástica tropical seropositiva (HAM) y seronegativa |
| title_full | Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis Dos signos de Babinski en pacientes con paraparesia espástica tropical seropositiva (HAM) y seronegativa |
| title_fullStr | Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis Dos signos de Babinski en pacientes con paraparesia espástica tropical seropositiva (HAM) y seronegativa |
| title_full_unstemmed | Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis Dos signos de Babinski en pacientes con paraparesia espástica tropical seropositiva (HAM) y seronegativa |
| title_short | Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis Dos signos de Babinski en pacientes con paraparesia espástica tropical seropositiva (HAM) y seronegativa |
| title_sort | two babinski signs in seropositive ham and seronegative tropical spastic paraparesis dos signos de babinski en pacientes con paraparesia espastica tropical seropositiva ham y seronegativa |
| topic | HAM TSP signo de Babinski plus neurorehabilitación HAM TSP Babinski plus sign mycotoxins neurorehabilitation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000500016 |
| work_keys_str_mv | AT fidiaseleonsarmiento twobabinskisignsinseropositivehamandseronegativetropicalspasticparaparesisdossignosdebabinskienpacientesconparaparesiaespasticatropicalseropositivahamyseronegativa AT andrescalderon twobabinskisignsinseropositivehamandseronegativetropicalspasticparaparesisdossignosdebabinskienpacientesconparaparesiaespasticatropicalseropositivahamyseronegativa AT hernanghernandez twobabinskisignsinseropositivehamandseronegativetropicalspasticparaparesisdossignosdebabinskienpacientesconparaparesiaespasticatropicalseropositivahamyseronegativa |