De novo synthesis of 1-phenethylisoquinoline in engineered Escherichia coli

De novo synthesis of 1-phenethylisoquinoline in engineered Escherichia coli

Phenylethylisoquinoline alkaloids (PIAs) are medicinally important natural products derived from the 1-phenylethylisoquinoline precursor. Heterologous production of the PIAs remains challenging due to the incomplete elucidation of biosynthetic pathway and the lack of proper microbial cell factory de...

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Bibliographic Details
Main Authors: Yaping Mao, Jiangming Zhu, Qian Zhang, Guangyi Wang, Hongkai Fan, Xiaowei Zhang, Yuwei Sun, Yong Wang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-03-01
Series:Synthetic and Systems Biotechnology
Subjects:
Phenylethylisoquinoline alkaloids
1-Phenethylisoquinoline
De novo biosynthesis
Escherichia coli
Reductases
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X24001376
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