Impaired Brain Information Transmission Efficiency and Flexibility in Parkinson’s Disease and Rapid Eye Movement Sleep Behavior Disorder: Evidence from Functional Connectivity and Functional Dynamics
Parkinson’s disease (PD) is a common neurodegenerative disorder. Rapid eye movement sleep behavior disorder (RBD) is one of the prodromal symptoms of PD. Studies have shown that brain information transmission is affected in PD patients. Consequently, we hypothesized that brain information transmissi...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2022/7495371 |
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| _version_ | 1849405111502110720 |
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| author | Jing Wei Jiaqi Lyu Jie Xiang Yan Niu Lan Yang Chanjuan Fan Dandan Li Yanli Yang |
| author_facet | Jing Wei Jiaqi Lyu Jie Xiang Yan Niu Lan Yang Chanjuan Fan Dandan Li Yanli Yang |
| author_sort | Jing Wei |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is a common neurodegenerative disorder. Rapid eye movement sleep behavior disorder (RBD) is one of the prodromal symptoms of PD. Studies have shown that brain information transmission is affected in PD patients. Consequently, we hypothesized that brain information transmission is impaired in RBD and PD. To prove our hypothesis, we performed functional connectivity (FC) and functional dynamics analysis of three aspects—based on the whole brain, within the resting-state network (RSN), and the interaction between RSNs—using normal control (NC) (n = 21), RBD (n = 24), and PD (n = 45) resting-state functional magnetic resonance imaging (rs-fMRI) data sets. Furthermore, we tested the explanatory power of FC and functional dynamics for the clinical features. Our results found that the global functional dynamics and FC of RBD and PD were impaired. Within RSN, the impairment concentrated in the visual network (VIS) and sensorimotor network (SMN), and the impaired degree of SMN in RBD was higher than that in PD. On the interaction between RSNs, RBD showed a widespread decrease, and PD showed a focal decrease which concentrated in SMN and VIS. Finally, we proved FC and functional dynamics were related to clinical features. These differences confirmed that brain information transmission efficiency and flexibility are impaired in RBD and PD, and these impairments are associated with the clinical features of patients. |
| format | Article |
| id | doaj-art-46cbff52969445a18e9ac375d5b9bb47 |
| institution | Kabale University |
| issn | 2042-0080 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-46cbff52969445a18e9ac375d5b9bb472025-08-20T03:36:45ZengWileyParkinson's Disease2042-00802022-01-01202210.1155/2022/7495371Impaired Brain Information Transmission Efficiency and Flexibility in Parkinson’s Disease and Rapid Eye Movement Sleep Behavior Disorder: Evidence from Functional Connectivity and Functional DynamicsJing Wei0Jiaqi Lyu1Jie Xiang2Yan Niu3Lan Yang4Chanjuan Fan5Dandan Li6Yanli Yang7College of Information and ComputerCollege of Information and ComputerCollege of Information and ComputerCollege of Information and ComputerCollege of Information and ComputerCollege of Information and ComputerCollege of Information and ComputerCollege of Information and ComputerParkinson’s disease (PD) is a common neurodegenerative disorder. Rapid eye movement sleep behavior disorder (RBD) is one of the prodromal symptoms of PD. Studies have shown that brain information transmission is affected in PD patients. Consequently, we hypothesized that brain information transmission is impaired in RBD and PD. To prove our hypothesis, we performed functional connectivity (FC) and functional dynamics analysis of three aspects—based on the whole brain, within the resting-state network (RSN), and the interaction between RSNs—using normal control (NC) (n = 21), RBD (n = 24), and PD (n = 45) resting-state functional magnetic resonance imaging (rs-fMRI) data sets. Furthermore, we tested the explanatory power of FC and functional dynamics for the clinical features. Our results found that the global functional dynamics and FC of RBD and PD were impaired. Within RSN, the impairment concentrated in the visual network (VIS) and sensorimotor network (SMN), and the impaired degree of SMN in RBD was higher than that in PD. On the interaction between RSNs, RBD showed a widespread decrease, and PD showed a focal decrease which concentrated in SMN and VIS. Finally, we proved FC and functional dynamics were related to clinical features. These differences confirmed that brain information transmission efficiency and flexibility are impaired in RBD and PD, and these impairments are associated with the clinical features of patients.http://dx.doi.org/10.1155/2022/7495371 |
| spellingShingle | Jing Wei Jiaqi Lyu Jie Xiang Yan Niu Lan Yang Chanjuan Fan Dandan Li Yanli Yang Impaired Brain Information Transmission Efficiency and Flexibility in Parkinson’s Disease and Rapid Eye Movement Sleep Behavior Disorder: Evidence from Functional Connectivity and Functional Dynamics Parkinson's Disease |
| title | Impaired Brain Information Transmission Efficiency and Flexibility in Parkinson’s Disease and Rapid Eye Movement Sleep Behavior Disorder: Evidence from Functional Connectivity and Functional Dynamics |
| title_full | Impaired Brain Information Transmission Efficiency and Flexibility in Parkinson’s Disease and Rapid Eye Movement Sleep Behavior Disorder: Evidence from Functional Connectivity and Functional Dynamics |
| title_fullStr | Impaired Brain Information Transmission Efficiency and Flexibility in Parkinson’s Disease and Rapid Eye Movement Sleep Behavior Disorder: Evidence from Functional Connectivity and Functional Dynamics |
| title_full_unstemmed | Impaired Brain Information Transmission Efficiency and Flexibility in Parkinson’s Disease and Rapid Eye Movement Sleep Behavior Disorder: Evidence from Functional Connectivity and Functional Dynamics |
| title_short | Impaired Brain Information Transmission Efficiency and Flexibility in Parkinson’s Disease and Rapid Eye Movement Sleep Behavior Disorder: Evidence from Functional Connectivity and Functional Dynamics |
| title_sort | impaired brain information transmission efficiency and flexibility in parkinson s disease and rapid eye movement sleep behavior disorder evidence from functional connectivity and functional dynamics |
| url | http://dx.doi.org/10.1155/2022/7495371 |
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