5,6-dihydroxyflavone exerts anti-betacoronavirus activity by blocking viral entry to host cells

5,6-dihydroxyflavone exerts anti-betacoronavirus activity by blocking viral entry to host cells

Baicalin, a bioactive flavone found in Scutellaria baicalensis Georgi has anti-SARS-CoV-2 infection by targeting viral 3C-like protease (3CLpro). However, little is known about the antiviral activity of its 7-deoxy analogue, 5,6-dihydroxyflavone (5,6-DHF), especially against betacoronaviruses (beta-...

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Bibliographic Details
Main Authors: Yujia Cao, Kah Man Lai, Hongling Zheng, Yee Joo Tan, Dejian Huang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Virus Research
Subjects:
Anti-coronavirus
5,6-dihydroxyflavone
Receptor-binding domain
Flavones
Sars-cov-2
Online Access:http://www.sciencedirect.com/science/article/pii/S0168170225000553
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