Diagnosing Sporadic Creutzfeldt-Jakob Disease in a Patient with a Suspected Status Epilepticus in the Intensive Care Unit
Objective. Several tests are available in the diagnostics of sporadic Creutzfeldt-Jakob disease (sCJD); however, none of these is conclusive. We review the values of these tests, from an intensive care unit (ICU) perspective. Methods. Case report and review of the literature. Results. A 53-year-old...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/630141 |
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| author | Harm J. van der Horn Peter H. Egbers Michaël A. Kuiper Wouter J. Schuiling |
| author_facet | Harm J. van der Horn Peter H. Egbers Michaël A. Kuiper Wouter J. Schuiling |
| author_sort | Harm J. van der Horn |
| collection | DOAJ |
| description | Objective. Several tests are available in the diagnostics of sporadic Creutzfeldt-Jakob disease (sCJD); however, none of these is conclusive. We review the values of these tests, from an intensive care unit (ICU) perspective. Methods. Case report and review of the literature. Results. A 53-year-old woman initially presenting with psychiatric symptoms developed myoclonus and was admitted 1 month later to the ICU with a suspected nonconvulsive status epilepticus and respiratory insufficiency, probably due to extensive antiepileptic drug therapy. Typical MRI and EEG findings and a positive 14-3-3 protein led to the diagnosis of sCJD. All treatments were terminated, and autopsy confirmed sCJD. Conclusions. Clinical signs combined with MRI, EEG, and 14-3-3 and/or tau protein determination might be sufficient to diagnose or exclude sCJD and may therefore prevent the application of unnecessary diagnostic tests. |
| format | Article |
| id | doaj-art-46bf5f1993ff48d6a3d5a9b2aa5aa8a2 |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-46bf5f1993ff48d6a3d5a9b2aa5aa8a22025-02-03T07:25:40ZengWileyCase Reports in Neurological Medicine2090-66682090-66762013-01-01201310.1155/2013/630141630141Diagnosing Sporadic Creutzfeldt-Jakob Disease in a Patient with a Suspected Status Epilepticus in the Intensive Care UnitHarm J. van der Horn0Peter H. Egbers1Michaël A. Kuiper2Wouter J. Schuiling3University Medical Centre Groningen, GN, The NetherlandsDepartment of Intensive Care, The Medical Centre Leeuwarden, FR Leeuwarden, The NetherlandsDepartment of Intensive Care, The Medical Centre Leeuwarden, FR Leeuwarden, The NetherlandsDepartment of Neurology, The Medical Centre Leeuwarden, FR Leeuwarden, The NetherlandsObjective. Several tests are available in the diagnostics of sporadic Creutzfeldt-Jakob disease (sCJD); however, none of these is conclusive. We review the values of these tests, from an intensive care unit (ICU) perspective. Methods. Case report and review of the literature. Results. A 53-year-old woman initially presenting with psychiatric symptoms developed myoclonus and was admitted 1 month later to the ICU with a suspected nonconvulsive status epilepticus and respiratory insufficiency, probably due to extensive antiepileptic drug therapy. Typical MRI and EEG findings and a positive 14-3-3 protein led to the diagnosis of sCJD. All treatments were terminated, and autopsy confirmed sCJD. Conclusions. Clinical signs combined with MRI, EEG, and 14-3-3 and/or tau protein determination might be sufficient to diagnose or exclude sCJD and may therefore prevent the application of unnecessary diagnostic tests.http://dx.doi.org/10.1155/2013/630141 |
| spellingShingle | Harm J. van der Horn Peter H. Egbers Michaël A. Kuiper Wouter J. Schuiling Diagnosing Sporadic Creutzfeldt-Jakob Disease in a Patient with a Suspected Status Epilepticus in the Intensive Care Unit Case Reports in Neurological Medicine |
| title | Diagnosing Sporadic Creutzfeldt-Jakob Disease in a Patient with a Suspected Status Epilepticus in the Intensive Care Unit |
| title_full | Diagnosing Sporadic Creutzfeldt-Jakob Disease in a Patient with a Suspected Status Epilepticus in the Intensive Care Unit |
| title_fullStr | Diagnosing Sporadic Creutzfeldt-Jakob Disease in a Patient with a Suspected Status Epilepticus in the Intensive Care Unit |
| title_full_unstemmed | Diagnosing Sporadic Creutzfeldt-Jakob Disease in a Patient with a Suspected Status Epilepticus in the Intensive Care Unit |
| title_short | Diagnosing Sporadic Creutzfeldt-Jakob Disease in a Patient with a Suspected Status Epilepticus in the Intensive Care Unit |
| title_sort | diagnosing sporadic creutzfeldt jakob disease in a patient with a suspected status epilepticus in the intensive care unit |
| url | http://dx.doi.org/10.1155/2013/630141 |
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