Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder.
The human brain is the outcome of innumerable evolutionary processes; the systems genetics of psychiatric disorders could bear their signatures. On this basis, we analyzed five psychiatric disorders, attention deficit hyperactivity disorder, autism spectrum disorder (ASD), bipolar disorder, major de...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-02-01
|
| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1006618&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849722110178492416 |
|---|---|
| author | Renato Polimanti Joel Gelernter |
| author_facet | Renato Polimanti Joel Gelernter |
| author_sort | Renato Polimanti |
| collection | DOAJ |
| description | The human brain is the outcome of innumerable evolutionary processes; the systems genetics of psychiatric disorders could bear their signatures. On this basis, we analyzed five psychiatric disorders, attention deficit hyperactivity disorder, autism spectrum disorder (ASD), bipolar disorder, major depressive disorder, and schizophrenia (SCZ), using GWAS summary statistics from the Psychiatric Genomics Consortium. Machine learning-derived scores were used to investigate two natural-selection scenarios: complete selection (loci where a selected allele reached fixation) and incomplete selection (loci where a selected allele has not yet reached fixation). ASD GWAS results positively correlated with incomplete-selection (p = 3.53*10-4). Variants with ASD GWAS p<0.1 were shown to have a 19%-increased probability to be in the top-5% for incomplete-selection score (OR = 1.19, 95%CI = 1.11-1.8, p = 9.56*10-7). Investigating the effect directions of minor alleles, we observed an enrichment for positive associations in SNPs with ASD GWAS p<0.1 and top-5% incomplete-selection score (permutation p<10-4). Considering the set of these ASD-positive-associated variants, we observed gene-expression enrichments for brain and pituitary tissues (p = 2.3*10-5 and p = 3*10-5, respectively) and 53 gene ontology (GO) enrichments, such as nervous system development (GO:0007399, p = 7.57*10-12), synapse organization (GO:0050808, p = 8.29*10-7), and axon guidance (GO:0007411, p = 1.81*10-7). Previous genetic studies demonstrated that ASD positively correlates with childhood intelligence, college completion, and years of schooling. Accordingly, we hypothesize that certain ASD risk alleles were under positive selection during human evolution due to their involvement in neurogenesis and cognitive ability. |
| format | Article |
| id | doaj-art-46be525e098d446e9c9c59a63391c64e |
| institution | DOAJ |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2017-02-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj-art-46be525e098d446e9c9c59a63391c64e2025-08-20T03:11:26ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042017-02-01132e100661810.1371/journal.pgen.1006618Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder.Renato PolimantiJoel GelernterThe human brain is the outcome of innumerable evolutionary processes; the systems genetics of psychiatric disorders could bear their signatures. On this basis, we analyzed five psychiatric disorders, attention deficit hyperactivity disorder, autism spectrum disorder (ASD), bipolar disorder, major depressive disorder, and schizophrenia (SCZ), using GWAS summary statistics from the Psychiatric Genomics Consortium. Machine learning-derived scores were used to investigate two natural-selection scenarios: complete selection (loci where a selected allele reached fixation) and incomplete selection (loci where a selected allele has not yet reached fixation). ASD GWAS results positively correlated with incomplete-selection (p = 3.53*10-4). Variants with ASD GWAS p<0.1 were shown to have a 19%-increased probability to be in the top-5% for incomplete-selection score (OR = 1.19, 95%CI = 1.11-1.8, p = 9.56*10-7). Investigating the effect directions of minor alleles, we observed an enrichment for positive associations in SNPs with ASD GWAS p<0.1 and top-5% incomplete-selection score (permutation p<10-4). Considering the set of these ASD-positive-associated variants, we observed gene-expression enrichments for brain and pituitary tissues (p = 2.3*10-5 and p = 3*10-5, respectively) and 53 gene ontology (GO) enrichments, such as nervous system development (GO:0007399, p = 7.57*10-12), synapse organization (GO:0050808, p = 8.29*10-7), and axon guidance (GO:0007411, p = 1.81*10-7). Previous genetic studies demonstrated that ASD positively correlates with childhood intelligence, college completion, and years of schooling. Accordingly, we hypothesize that certain ASD risk alleles were under positive selection during human evolution due to their involvement in neurogenesis and cognitive ability.https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1006618&type=printable |
| spellingShingle | Renato Polimanti Joel Gelernter Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder. PLoS Genetics |
| title | Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder. |
| title_full | Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder. |
| title_fullStr | Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder. |
| title_full_unstemmed | Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder. |
| title_short | Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder. |
| title_sort | widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder |
| url | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1006618&type=printable |
| work_keys_str_mv | AT renatopolimanti widespreadsignaturesofpositiveselectionincommonriskallelesassociatedtoautismspectrumdisorder AT joelgelernter widespreadsignaturesofpositiveselectionincommonriskallelesassociatedtoautismspectrumdisorder |