Pharmacotherapy of apnoea-free sleep disorders in patients with metabolic syndrome
Aim. To evaluate the effectiveness and safety of zopiclone in apnoea-free sleep disorders among patients with metabolic syndrome (MS). Material and methods. The study included 60 patients with chronic cerebrovascular disease (CerVD) and MS (mean age 53,3±11,2 years). Zopiclone was administered in th...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2010-04-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/2042 |
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| author | O. V. Lyubshina A. L. Vertkin M. Yu. Maksimova |
| author_facet | O. V. Lyubshina A. L. Vertkin M. Yu. Maksimova |
| author_sort | O. V. Lyubshina |
| collection | DOAJ |
| description | Aim. To evaluate the effectiveness and safety of zopiclone in apnoea-free sleep disorders among patients with metabolic syndrome (MS). Material and methods. The study included 60 patients with chronic cerebrovascular disease (CerVD) and MS (mean age 53,3±11,2 years). Zopiclone was administered in the dose of 7,5 mg once a day, 30 minutes before going to bed, for 21 days. Therapy effectiveness was evaluated by various subjective and objective sleep assessment methods. Results. After a zopiclone treatment course, all patients reported substantial improvement of sleep quality. These beneficial effects were explained by changing sleep architecture — the duration of sleep phases and stages (%). In particular, Stage 1 of slow sleep phase, the most affected at the pre-treatment level, was significantly reduced by 20 %, while Stage 2 of slow sleep phase increased by 14 % (p<0,05). Conclusion. Zopiclone therapy in CerVD patients with MS and apnoea-free sleep disorders substantially improved subjective and objective sleep parameters. Zopiclone could be recommended as a first-choice medication in MS patients with apnoea-free sleep disorders. |
| format | Article |
| id | doaj-art-46b97c5e571d420ea25a8ddd18566b89 |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2010-04-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-46b97c5e571d420ea25a8ddd18566b892025-08-20T03:57:17Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252010-04-019254601754Pharmacotherapy of apnoea-free sleep disorders in patients with metabolic syndromeO. V. Lyubshina0A. L. Vertkin1M. Yu. Maksimova2Moscow State Medico-Stomatological University. MoscowMoscow State Medico-Stomatological University. MoscowMoscow State Medico-Stomatological University. MoscowAim. To evaluate the effectiveness and safety of zopiclone in apnoea-free sleep disorders among patients with metabolic syndrome (MS). Material and methods. The study included 60 patients with chronic cerebrovascular disease (CerVD) and MS (mean age 53,3±11,2 years). Zopiclone was administered in the dose of 7,5 mg once a day, 30 minutes before going to bed, for 21 days. Therapy effectiveness was evaluated by various subjective and objective sleep assessment methods. Results. After a zopiclone treatment course, all patients reported substantial improvement of sleep quality. These beneficial effects were explained by changing sleep architecture — the duration of sleep phases and stages (%). In particular, Stage 1 of slow sleep phase, the most affected at the pre-treatment level, was significantly reduced by 20 %, while Stage 2 of slow sleep phase increased by 14 % (p<0,05). Conclusion. Zopiclone therapy in CerVD patients with MS and apnoea-free sleep disorders substantially improved subjective and objective sleep parameters. Zopiclone could be recommended as a first-choice medication in MS patients with apnoea-free sleep disorders.https://cardiovascular.elpub.ru/jour/article/view/2042chronic cerebrovascular diseasemetabolic syndromesleep disordersinsomniazopiclone |
| spellingShingle | O. V. Lyubshina A. L. Vertkin M. Yu. Maksimova Pharmacotherapy of apnoea-free sleep disorders in patients with metabolic syndrome Кардиоваскулярная терапия и профилактика chronic cerebrovascular disease metabolic syndrome sleep disorders insomnia zopiclone |
| title | Pharmacotherapy of apnoea-free sleep disorders in patients with metabolic syndrome |
| title_full | Pharmacotherapy of apnoea-free sleep disorders in patients with metabolic syndrome |
| title_fullStr | Pharmacotherapy of apnoea-free sleep disorders in patients with metabolic syndrome |
| title_full_unstemmed | Pharmacotherapy of apnoea-free sleep disorders in patients with metabolic syndrome |
| title_short | Pharmacotherapy of apnoea-free sleep disorders in patients with metabolic syndrome |
| title_sort | pharmacotherapy of apnoea free sleep disorders in patients with metabolic syndrome |
| topic | chronic cerebrovascular disease metabolic syndrome sleep disorders insomnia zopiclone |
| url | https://cardiovascular.elpub.ru/jour/article/view/2042 |
| work_keys_str_mv | AT ovlyubshina pharmacotherapyofapnoeafreesleepdisordersinpatientswithmetabolicsyndrome AT alvertkin pharmacotherapyofapnoeafreesleepdisordersinpatientswithmetabolicsyndrome AT myumaksimova pharmacotherapyofapnoeafreesleepdisordersinpatientswithmetabolicsyndrome |