Pharmacotherapy of apnoea-free sleep disorders in patients with metabolic syndrome
Aim. To evaluate the effectiveness and safety of zopiclone in apnoea-free sleep disorders among patients with metabolic syndrome (MS). Material and methods. The study included 60 patients with chronic cerebrovascular disease (CerVD) and MS (mean age 53,3±11,2 years). Zopiclone was administered in th...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
2010-04-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/2042 |
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| Summary: | Aim. To evaluate the effectiveness and safety of zopiclone in apnoea-free sleep disorders among patients with metabolic syndrome (MS). Material and methods. The study included 60 patients with chronic cerebrovascular disease (CerVD) and MS (mean age 53,3±11,2 years). Zopiclone was administered in the dose of 7,5 mg once a day, 30 minutes before going to bed, for 21 days. Therapy effectiveness was evaluated by various subjective and objective sleep assessment methods. Results. After a zopiclone treatment course, all patients reported substantial improvement of sleep quality. These beneficial effects were explained by changing sleep architecture — the duration of sleep phases and stages (%). In particular, Stage 1 of slow sleep phase, the most affected at the pre-treatment level, was significantly reduced by 20 %, while Stage 2 of slow sleep phase increased by 14 % (p<0,05). Conclusion. Zopiclone therapy in CerVD patients with MS and apnoea-free sleep disorders substantially improved subjective and objective sleep parameters. Zopiclone could be recommended as a first-choice medication in MS patients with apnoea-free sleep disorders. |
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| ISSN: | 1728-8800 2619-0125 |