Predictors of interferon-gamma release assay results and their association with COVID-19 infection outcomes
BACKGROUND: An ‘indeterminate’ interferon-gamma release assay (IGRA) result used in the diagnosis of latent TB infection (LTBI) is most commonly due to an inadequate control (or ‘mitogen’) response, which may reflect underlying T-cell dysfunction. METHODS: We performed a single-centre, retrospective...
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| Language: | English |
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International Union Against Tuberculosis and Lung Disease (The Union)
2024-10-01
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| Series: | IJTLD Open |
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| Online Access: | https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000010/art00004 |
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| author | S.J.W. Kang G.W. Eather F. Qureshi J.R. Scott |
| author_facet | S.J.W. Kang G.W. Eather F. Qureshi J.R. Scott |
| author_sort | S.J.W. Kang |
| collection | DOAJ |
| description | BACKGROUND: An ‘indeterminate’ interferon-gamma release assay (IGRA) result used in the diagnosis of latent TB infection (LTBI) is most commonly due to an inadequate control (or ‘mitogen’) response, which may reflect underlying T-cell dysfunction. METHODS: We performed a single-centre, retrospective study on COVID-19 patients admitted to a tertiary referral hospital who had IGRA testing conducted over a 5-month period. The primary outcomes included predictors of indeterminate IGRA results and associations with COVID-19 outcomes. RESULTS: A total of 181 patients were included for analysis. Approximately one-third of patients hospitalised with COVID-19 with IGRA testing performed (60/181) had an indeterminate result. The likelihood of an indeterminate IGRA was increased in patients with a history of solid organ transplant and a higher severity of COVID-19 at the time of testing. An indeterminate IGRA was associated with a higher risk of severe COVID-19 and a higher risk of admission to the ICU during admission to the hospital. No difference in mortality between the two subgroups was found. CONCLUSION: Our study demonstrated that COVID-19 patients on immunosuppression had a high likelihood of an indeterminate IGRA result, which was associated with markers of disease severity and immunosuppression. In this cohort, an indeterminate result was associated with worse COVID-19 outcomes. |
| format | Article |
| id | doaj-art-46ae0b480a5a4f758cc1ea70feda7825 |
| institution | Kabale University |
| issn | 3005-7590 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | International Union Against Tuberculosis and Lung Disease (The Union) |
| record_format | Article |
| series | IJTLD Open |
| spelling | doaj-art-46ae0b480a5a4f758cc1ea70feda78252025-01-23T13:28:38ZengInternational Union Against Tuberculosis and Lung Disease (The Union)IJTLD Open3005-75902024-10-0111044344810.5588/ijtldopen.24.01804Predictors of interferon-gamma release assay results and their association with COVID-19 infection outcomesS.J.W. Kang0G.W. Eather1F. Qureshi2J.R. Scott3Department of Respiratory, Sleep and Mycobacterial Medicine, Princess Alexandra Hospital, Metro South Health, Brisbane, QLD, Australia;Department of Respiratory, Sleep and Mycobacterial Medicine, Princess Alexandra Hospital, Metro South Health, Brisbane, QLD, Australia;Department of Respiratory, Sleep and Mycobacterial Medicine, Princess Alexandra Hospital, Metro South Health, Brisbane, QLD, Australia;QCIF Bioinformatics, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.BACKGROUND: An ‘indeterminate’ interferon-gamma release assay (IGRA) result used in the diagnosis of latent TB infection (LTBI) is most commonly due to an inadequate control (or ‘mitogen’) response, which may reflect underlying T-cell dysfunction. METHODS: We performed a single-centre, retrospective study on COVID-19 patients admitted to a tertiary referral hospital who had IGRA testing conducted over a 5-month period. The primary outcomes included predictors of indeterminate IGRA results and associations with COVID-19 outcomes. RESULTS: A total of 181 patients were included for analysis. Approximately one-third of patients hospitalised with COVID-19 with IGRA testing performed (60/181) had an indeterminate result. The likelihood of an indeterminate IGRA was increased in patients with a history of solid organ transplant and a higher severity of COVID-19 at the time of testing. An indeterminate IGRA was associated with a higher risk of severe COVID-19 and a higher risk of admission to the ICU during admission to the hospital. No difference in mortality between the two subgroups was found. CONCLUSION: Our study demonstrated that COVID-19 patients on immunosuppression had a high likelihood of an indeterminate IGRA result, which was associated with markers of disease severity and immunosuppression. In this cohort, an indeterminate result was associated with worse COVID-19 outcomes.https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000010/art00004igracoronavirus disease 2019immunosuppression |
| spellingShingle | S.J.W. Kang G.W. Eather F. Qureshi J.R. Scott Predictors of interferon-gamma release assay results and their association with COVID-19 infection outcomes IJTLD Open igra coronavirus disease 2019 immunosuppression |
| title | Predictors of interferon-gamma release assay results and their association with COVID-19 infection outcomes |
| title_full | Predictors of interferon-gamma release assay results and their association with COVID-19 infection outcomes |
| title_fullStr | Predictors of interferon-gamma release assay results and their association with COVID-19 infection outcomes |
| title_full_unstemmed | Predictors of interferon-gamma release assay results and their association with COVID-19 infection outcomes |
| title_short | Predictors of interferon-gamma release assay results and their association with COVID-19 infection outcomes |
| title_sort | predictors of interferon gamma release assay results and their association with covid 19 infection outcomes |
| topic | igra coronavirus disease 2019 immunosuppression |
| url | https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000010/art00004 |
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