Differential effects of neurodegeneration biomarkers on subclinical cognitive decline
Abstract Introduction Neurodegeneration appears to be the biological mechanism most proximate to cognitive decline in Alzheimer's disease. We test whether t‐tau and alternative biomarkers of neurodegeneration—neurogranin and neurofilament light protein (NFL)—add value in predicting subclinical...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
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| Online Access: | https://doi.org/10.1016/j.trci.2019.02.004 |
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| author | Andrew P. Merluzzi Nicholas M. Vogt Derek Norton Erin Jonaitis Lindsay R. Clark Cynthia M. Carlsson Sterling C. Johnson Sanjay Asthana Kaj Blennow Henrik Zetterberg Barbara B. Bendlin |
| author_facet | Andrew P. Merluzzi Nicholas M. Vogt Derek Norton Erin Jonaitis Lindsay R. Clark Cynthia M. Carlsson Sterling C. Johnson Sanjay Asthana Kaj Blennow Henrik Zetterberg Barbara B. Bendlin |
| author_sort | Andrew P. Merluzzi |
| collection | DOAJ |
| description | Abstract Introduction Neurodegeneration appears to be the biological mechanism most proximate to cognitive decline in Alzheimer's disease. We test whether t‐tau and alternative biomarkers of neurodegeneration—neurogranin and neurofilament light protein (NFL)—add value in predicting subclinical cognitive decline. Methods One hundred fifty cognitively unimpaired participants received a lumbar puncture for cerebrospinal fluid and at least two neuropsychological examinations (mean age at first visit = 59.3 ± 6.3 years; 67% female). Linear mixed effects models were used with cognitive composite scores as outcomes. Neurodegeneration interactions terms were the primary predictors of interest: age × NFL or age × neurogranin or age × t‐tau. Models were compared using likelihood ratio tests. Results Age × NFL accounted for a significant amount of variation in longitudinal change on preclinical Alzheimer's cognitive composite scores, memory composite scores, and learning scores, whereas age × neurogranin and age × t‐tau did not. Discussion These data suggest that NFL may be more sensitive to subclinical cognitive decline compared to other proposed biomarkers for neurodegeneration. |
| format | Article |
| id | doaj-art-46a8afe7f71a495c8e6926cf841a084b |
| institution | Kabale University |
| issn | 2352-8737 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj-art-46a8afe7f71a495c8e6926cf841a084b2025-08-20T03:30:39ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372019-01-015112913810.1016/j.trci.2019.02.004Differential effects of neurodegeneration biomarkers on subclinical cognitive declineAndrew P. Merluzzi0Nicholas M. Vogt1Derek Norton2Erin Jonaitis3Lindsay R. Clark4Cynthia M. Carlsson5Sterling C. Johnson6Sanjay Asthana7Kaj Blennow8Henrik Zetterberg9Barbara B. Bendlin10Wisconsin Alzheimer's Disease Research CenterUniversity of Wisconsin–MadisonMadisonWIUSAWisconsin Alzheimer's Disease Research CenterUniversity of Wisconsin–MadisonMadisonWIUSADepartment of Biostatistics and Medical InformaticsUniversity of Wisconsin–MadisonMadisonWIUSADepartment of Biostatistics and Medical InformaticsUniversity of Wisconsin–MadisonMadisonWIUSAWisconsin Alzheimer's Disease Research CenterUniversity of Wisconsin–MadisonMadisonWIUSAWisconsin Alzheimer's Disease Research CenterUniversity of Wisconsin–MadisonMadisonWIUSAWisconsin Alzheimer's Disease Research CenterUniversity of Wisconsin–MadisonMadisonWIUSAWisconsin Alzheimer's Disease Research CenterUniversity of Wisconsin–MadisonMadisonWIUSADepartment of Psychiatry and NeurochemistryInstitute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of GothenburgMölndalSwedenDepartment of Psychiatry and NeurochemistryInstitute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of GothenburgMölndalSwedenWisconsin Alzheimer's Disease Research CenterUniversity of Wisconsin–MadisonMadisonWIUSAAbstract Introduction Neurodegeneration appears to be the biological mechanism most proximate to cognitive decline in Alzheimer's disease. We test whether t‐tau and alternative biomarkers of neurodegeneration—neurogranin and neurofilament light protein (NFL)—add value in predicting subclinical cognitive decline. Methods One hundred fifty cognitively unimpaired participants received a lumbar puncture for cerebrospinal fluid and at least two neuropsychological examinations (mean age at first visit = 59.3 ± 6.3 years; 67% female). Linear mixed effects models were used with cognitive composite scores as outcomes. Neurodegeneration interactions terms were the primary predictors of interest: age × NFL or age × neurogranin or age × t‐tau. Models were compared using likelihood ratio tests. Results Age × NFL accounted for a significant amount of variation in longitudinal change on preclinical Alzheimer's cognitive composite scores, memory composite scores, and learning scores, whereas age × neurogranin and age × t‐tau did not. Discussion These data suggest that NFL may be more sensitive to subclinical cognitive decline compared to other proposed biomarkers for neurodegeneration.https://doi.org/10.1016/j.trci.2019.02.004Alzheimer's diseaseBiomarkersCognitionNeurodegenerationAmyloidCognitive decline |
| spellingShingle | Andrew P. Merluzzi Nicholas M. Vogt Derek Norton Erin Jonaitis Lindsay R. Clark Cynthia M. Carlsson Sterling C. Johnson Sanjay Asthana Kaj Blennow Henrik Zetterberg Barbara B. Bendlin Differential effects of neurodegeneration biomarkers on subclinical cognitive decline Alzheimer’s & Dementia: Translational Research & Clinical Interventions Alzheimer's disease Biomarkers Cognition Neurodegeneration Amyloid Cognitive decline |
| title | Differential effects of neurodegeneration biomarkers on subclinical cognitive decline |
| title_full | Differential effects of neurodegeneration biomarkers on subclinical cognitive decline |
| title_fullStr | Differential effects of neurodegeneration biomarkers on subclinical cognitive decline |
| title_full_unstemmed | Differential effects of neurodegeneration biomarkers on subclinical cognitive decline |
| title_short | Differential effects of neurodegeneration biomarkers on subclinical cognitive decline |
| title_sort | differential effects of neurodegeneration biomarkers on subclinical cognitive decline |
| topic | Alzheimer's disease Biomarkers Cognition Neurodegeneration Amyloid Cognitive decline |
| url | https://doi.org/10.1016/j.trci.2019.02.004 |
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