Research Progress on the Role of Zinc Finger Protein in Colorectal Cancer
ABSTRACT Background Colorectal cancer is one of the most prevalent malignancies worldwide, with a tendency of increasing incidence in developed countries, which poses a significant threat to the patients' physical and mental health. Recent Findings The process of gene transcription affects the...
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| Format: | Article |
| Language: | English |
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Wiley
2025-03-01
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| Series: | Cancer Reports |
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| Online Access: | https://doi.org/10.1002/cnr2.70123 |
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| author | Tang Yu Jiumei Zhao Ziwei Li Chenglong Pan Jialing Liu Kepu Zheng Xiaohao Wang Yan Zhang |
| author_facet | Tang Yu Jiumei Zhao Ziwei Li Chenglong Pan Jialing Liu Kepu Zheng Xiaohao Wang Yan Zhang |
| author_sort | Tang Yu |
| collection | DOAJ |
| description | ABSTRACT Background Colorectal cancer is one of the most prevalent malignancies worldwide, with a tendency of increasing incidence in developed countries, which poses a significant threat to the patients' physical and mental health. Recent Findings The process of gene transcription affects the important physiological functions of cells, so the normal expression of transcription factors is an important prerequisite for maintaining cellular homeostasis. Changes in the level of zinc finger proteins, the most prevalent transcription factor, may play an important trigger for the development of colorectal cancer. Different zinc finger proteins play different roles in terms of promoting or inhibiting cancer development. Conclusion This paper briefly reviews the classification, functional characteristics, and expression changes of zinc finger proteins in colorectal cancer, it focuses on how they regulate gene transcription, influence on common signaling pathways, and their potential for translational studies and clinical applications. The objective is to stimulate new ideas for their study of colorectal cancer while also providing foundational information to guide drug development and treatment strategies for colorectal cancer patients in clinical settings. |
| format | Article |
| id | doaj-art-46a51eba2a714eb4ac90df488cc7be77 |
| institution | OA Journals |
| issn | 2573-8348 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj-art-46a51eba2a714eb4ac90df488cc7be772025-08-20T01:50:10ZengWileyCancer Reports2573-83482025-03-0183n/an/a10.1002/cnr2.70123Research Progress on the Role of Zinc Finger Protein in Colorectal CancerTang Yu0Jiumei Zhao1Ziwei Li2Chenglong Pan3Jialing Liu4Kepu Zheng5Xiaohao Wang6Yan Zhang7The Third Affiliated Hospital of Kunming Medical University Kunming Medical University Kunming ChinaChongqing Nanchuan District People's Hospital Chongqing Medical University Chongqing ChinaDepartment of Gynecology and Obstetrics, Chongqing Health Center for Women and Children Women and Children's Hospital of Chongqing Medical University Chongqing ChinaThe Third Affiliated Hospital of Kunming Medical University Kunming Medical University Kunming ChinaThe Third Affiliated Hospital of Kunming Medical University Kunming Medical University Kunming ChinaThe Third Affiliated Hospital of Kunming Medical University Kunming Medical University Kunming ChinaDepartment of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital Chongqing Medical University Chongqing ChinaDepartment of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital Chongqing Medical University Chongqing ChinaABSTRACT Background Colorectal cancer is one of the most prevalent malignancies worldwide, with a tendency of increasing incidence in developed countries, which poses a significant threat to the patients' physical and mental health. Recent Findings The process of gene transcription affects the important physiological functions of cells, so the normal expression of transcription factors is an important prerequisite for maintaining cellular homeostasis. Changes in the level of zinc finger proteins, the most prevalent transcription factor, may play an important trigger for the development of colorectal cancer. Different zinc finger proteins play different roles in terms of promoting or inhibiting cancer development. Conclusion This paper briefly reviews the classification, functional characteristics, and expression changes of zinc finger proteins in colorectal cancer, it focuses on how they regulate gene transcription, influence on common signaling pathways, and their potential for translational studies and clinical applications. The objective is to stimulate new ideas for their study of colorectal cancer while also providing foundational information to guide drug development and treatment strategies for colorectal cancer patients in clinical settings.https://doi.org/10.1002/cnr2.70123colorectal cancermechanism of actionsignaling pathwaytreatmentzinc finger protein |
| spellingShingle | Tang Yu Jiumei Zhao Ziwei Li Chenglong Pan Jialing Liu Kepu Zheng Xiaohao Wang Yan Zhang Research Progress on the Role of Zinc Finger Protein in Colorectal Cancer Cancer Reports colorectal cancer mechanism of action signaling pathway treatment zinc finger protein |
| title | Research Progress on the Role of Zinc Finger Protein in Colorectal Cancer |
| title_full | Research Progress on the Role of Zinc Finger Protein in Colorectal Cancer |
| title_fullStr | Research Progress on the Role of Zinc Finger Protein in Colorectal Cancer |
| title_full_unstemmed | Research Progress on the Role of Zinc Finger Protein in Colorectal Cancer |
| title_short | Research Progress on the Role of Zinc Finger Protein in Colorectal Cancer |
| title_sort | research progress on the role of zinc finger protein in colorectal cancer |
| topic | colorectal cancer mechanism of action signaling pathway treatment zinc finger protein |
| url | https://doi.org/10.1002/cnr2.70123 |
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