Fecal microbiota transplantation-current perspective on human health
Recently, microbiome medicine has attracted the attention of researchers. While this rapidly growing medical approach for various diseases and disorders is changing the paradigm, it is imperative to weigh both its benefits and the associated risk factors. For instance, manipulation of the gut microb...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1523870/full |
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| author | Zixuan Cao Tingting Gao Ousman Bajinka Yali Zhang Xingxing Yuan |
| author_facet | Zixuan Cao Tingting Gao Ousman Bajinka Yali Zhang Xingxing Yuan |
| author_sort | Zixuan Cao |
| collection | DOAJ |
| description | Recently, microbiome medicine has attracted the attention of researchers. While this rapidly growing medical approach for various diseases and disorders is changing the paradigm, it is imperative to weigh both its benefits and the associated risk factors. For instance, manipulation of the gut microbiota (GM) has positive effects on metabolic and neurodegenerative diseases. Notably, fecal microbiota transplantation (FMT), a complex method, has shown promise; however, many doubt its feasibility without adverse effects on human health. Given the number of human clinical trials investigating FMT for the treatment of various disorders, this review summarizes recent findings on its impact on human health. This review summarizes the metabolic responses associated with FMT and their reversal effects on gastrointestinal infections, behavioral changes, and immune responses. Additionally, this review discusses the role of FMT in antimicrobial resistance and its co-supplementation effects on human health, safety, potential risks, limitations, prospects, and recommendations. Although this review does not cover all the studies in the database, the searched terms for FMT and human health in clinical trials are sufficient to provide a summary of the current perspective. |
| format | Article |
| id | doaj-art-469f95c8c65b44d7ab0cad91d3604c4e |
| institution | DOAJ |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-469f95c8c65b44d7ab0cad91d3604c4e2025-08-20T02:56:58ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-03-011210.3389/fmed.2025.15238701523870Fecal microbiota transplantation-current perspective on human healthZixuan Cao0Tingting Gao1Ousman Bajinka2Yali Zhang3Xingxing Yuan4Heilongjiang Academy of Traditional Chinese Medicine, Harbin, ChinaHeilongjiang Academy of Traditional Chinese Medicine, Harbin, ChinaCountry School of Medicine and Allied Health Sciences, University of The Gambia, Banjul, GambiaHeilongjiang Academy of Traditional Chinese Medicine, Harbin, ChinaHeilongjiang Academy of Traditional Chinese Medicine, Harbin, ChinaRecently, microbiome medicine has attracted the attention of researchers. While this rapidly growing medical approach for various diseases and disorders is changing the paradigm, it is imperative to weigh both its benefits and the associated risk factors. For instance, manipulation of the gut microbiota (GM) has positive effects on metabolic and neurodegenerative diseases. Notably, fecal microbiota transplantation (FMT), a complex method, has shown promise; however, many doubt its feasibility without adverse effects on human health. Given the number of human clinical trials investigating FMT for the treatment of various disorders, this review summarizes recent findings on its impact on human health. This review summarizes the metabolic responses associated with FMT and their reversal effects on gastrointestinal infections, behavioral changes, and immune responses. Additionally, this review discusses the role of FMT in antimicrobial resistance and its co-supplementation effects on human health, safety, potential risks, limitations, prospects, and recommendations. Although this review does not cover all the studies in the database, the searched terms for FMT and human health in clinical trials are sufficient to provide a summary of the current perspective.https://www.frontiersin.org/articles/10.3389/fmed.2025.1523870/fullfecal microbiota transplantationhuman healthmetabolic disordersmicrobiome medicinegut microbiota |
| spellingShingle | Zixuan Cao Tingting Gao Ousman Bajinka Yali Zhang Xingxing Yuan Fecal microbiota transplantation-current perspective on human health Frontiers in Medicine fecal microbiota transplantation human health metabolic disorders microbiome medicine gut microbiota |
| title | Fecal microbiota transplantation-current perspective on human health |
| title_full | Fecal microbiota transplantation-current perspective on human health |
| title_fullStr | Fecal microbiota transplantation-current perspective on human health |
| title_full_unstemmed | Fecal microbiota transplantation-current perspective on human health |
| title_short | Fecal microbiota transplantation-current perspective on human health |
| title_sort | fecal microbiota transplantation current perspective on human health |
| topic | fecal microbiota transplantation human health metabolic disorders microbiome medicine gut microbiota |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1523870/full |
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