2-(4-Oxo-1,3-thiazolidin-2-ylidene)acetamid as promising scaffold for designing new antifungal compounds
1,3-Thiazolidin-4-one derivatives with a exocyclic C=C double bond in position 2 of the hetero ring have a wide spectrum of biological activity, but their fungicidal activity has not been studied as much as it should be. This paper presents a simple and convenient approach for obtaining potential an...
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| Format: | Article |
| Language: | English |
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Ural Federal University
2022-12-01
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| Series: | Chimica Techno Acta |
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| Online Access: | https://chimicatechnoacta.ru/article/view/6411 |
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| author | Konstantin L. Obydennov Tatiana A. Kalinina Daria V. Ryabova Maria F. Kosterina Tatiana V. Glukhareva |
| author_facet | Konstantin L. Obydennov Tatiana A. Kalinina Daria V. Ryabova Maria F. Kosterina Tatiana V. Glukhareva |
| author_sort | Konstantin L. Obydennov |
| collection | DOAJ |
| description | 1,3-Thiazolidin-4-one derivatives with a exocyclic C=C double bond in position 2 of the hetero ring have a wide spectrum of biological activity, but their fungicidal activity has not been studied as much as it should be. This paper presents a simple and convenient approach for obtaining potential antifungal agents based on 2-(4-oxo-1,3-thiazolidin-2-ylidene)acetamides. The first examples of evaluating the fungicidal activity of 8 obtained compounds on 8 strains of phytopathogenic fungi are presented. A highly active compound 4e with EC50 of 0.85 and 2.29 µg/mL against A. solani and P. lingam, respectively, was found to be promising for further study. |
| format | Article |
| id | doaj-art-469e0f33775141e89bcfd4fa0d3e57d9 |
| institution | OA Journals |
| issn | 2411-1414 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Ural Federal University |
| record_format | Article |
| series | Chimica Techno Acta |
| spelling | doaj-art-469e0f33775141e89bcfd4fa0d3e57d92025-08-20T02:17:38ZengUral Federal UniversityChimica Techno Acta2411-14142022-12-0110110.15826/chimtech.2023.10.1.0647552-(4-Oxo-1,3-thiazolidin-2-ylidene)acetamid as promising scaffold for designing new antifungal compoundsKonstantin L. Obydennov0Tatiana A. Kalinina1Daria V. Ryabova2Maria F. Kosterina3Tatiana V. Glukhareva4Ural Federal UniversityUral Federal UniversityUral Federal UniversityUral Federal UniversityUral Federal University1,3-Thiazolidin-4-one derivatives with a exocyclic C=C double bond in position 2 of the hetero ring have a wide spectrum of biological activity, but their fungicidal activity has not been studied as much as it should be. This paper presents a simple and convenient approach for obtaining potential antifungal agents based on 2-(4-oxo-1,3-thiazolidin-2-ylidene)acetamides. The first examples of evaluating the fungicidal activity of 8 obtained compounds on 8 strains of phytopathogenic fungi are presented. A highly active compound 4e with EC50 of 0.85 and 2.29 µg/mL against A. solani and P. lingam, respectively, was found to be promising for further study.https://chimicatechnoacta.ru/article/view/64111,3-thiazolidinecyanoacetamideexocyclic double bondfungicidebiological activity |
| spellingShingle | Konstantin L. Obydennov Tatiana A. Kalinina Daria V. Ryabova Maria F. Kosterina Tatiana V. Glukhareva 2-(4-Oxo-1,3-thiazolidin-2-ylidene)acetamid as promising scaffold for designing new antifungal compounds Chimica Techno Acta 1,3-thiazolidine cyanoacetamide exocyclic double bond fungicide biological activity |
| title | 2-(4-Oxo-1,3-thiazolidin-2-ylidene)acetamid as promising scaffold for designing new antifungal compounds |
| title_full | 2-(4-Oxo-1,3-thiazolidin-2-ylidene)acetamid as promising scaffold for designing new antifungal compounds |
| title_fullStr | 2-(4-Oxo-1,3-thiazolidin-2-ylidene)acetamid as promising scaffold for designing new antifungal compounds |
| title_full_unstemmed | 2-(4-Oxo-1,3-thiazolidin-2-ylidene)acetamid as promising scaffold for designing new antifungal compounds |
| title_short | 2-(4-Oxo-1,3-thiazolidin-2-ylidene)acetamid as promising scaffold for designing new antifungal compounds |
| title_sort | 2 4 oxo 1 3 thiazolidin 2 ylidene acetamid as promising scaffold for designing new antifungal compounds |
| topic | 1,3-thiazolidine cyanoacetamide exocyclic double bond fungicide biological activity |
| url | https://chimicatechnoacta.ru/article/view/6411 |
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