Childhood cancer incidence in British Indians & Whites in Leicester, 1996-2008.
<h4>Background</h4>South Asians in England have an increased risk of childhood cancer but incidence by their individual ethnicities using self-assigned ethnicity is unknown. Our objective was to compare the incidence of childhood cancer in British Indians and Whites in Leicester, which h...
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Public Library of Science (PLoS)
2013-01-01
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| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061881&type=printable |
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| author | Shameq Sayeed Isobel Barnes Benjamin J Cairns Alexander Finlayson Raghib Ali |
| author_facet | Shameq Sayeed Isobel Barnes Benjamin J Cairns Alexander Finlayson Raghib Ali |
| author_sort | Shameq Sayeed |
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| description | <h4>Background</h4>South Asians in England have an increased risk of childhood cancer but incidence by their individual ethnicities using self-assigned ethnicity is unknown. Our objective was to compare the incidence of childhood cancer in British Indians and Whites in Leicester, which has virtually complete, self-assigned, ethnicity data and the largest population of Indians in England.<h4>Methods</h4>We obtained data on all cancer registrations from 1996 to 2008 for Leicester with ethnicity obtained by linkage to the Hospital Episodes Statistics database. Age-standardised incidence rates were calculated for childhood cancers in Indians and Whites as well as rate ratios, adjusted for age.<h4>Results</h4>There were 33 cancers registered among Indian children and 39 among White children. The incidence rate for Indians was greater compared to Whites for all cancers combined (RR 1.82 (95% CI 1.14 to 2.89); p = 0.01), with some evidence of increased risk of leukaemia (RR 2.20 (0.95 to 5.07); p = 0.07), lymphoma (RR 3.96 (0.99 to 15.84); p = 0.04) and central nervous system tumours (RR 2.70 (1.00 to 7.26); p = 0.05). Rates were also higher in British Indian children compared to children in India.<h4>Conclusions</h4>British Indian children in Leicester had an increased risk of developing cancer compared to White children, largely due to a higher incidence of central nervous system and haematological malignancies. |
| format | Article |
| id | doaj-art-469c20a6480444b4bd7d4e94c59dc4ac |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-469c20a6480444b4bd7d4e94c59dc4ac2025-08-20T02:30:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0184e6188110.1371/journal.pone.0061881Childhood cancer incidence in British Indians & Whites in Leicester, 1996-2008.Shameq SayeedIsobel BarnesBenjamin J CairnsAlexander FinlaysonRaghib Ali<h4>Background</h4>South Asians in England have an increased risk of childhood cancer but incidence by their individual ethnicities using self-assigned ethnicity is unknown. Our objective was to compare the incidence of childhood cancer in British Indians and Whites in Leicester, which has virtually complete, self-assigned, ethnicity data and the largest population of Indians in England.<h4>Methods</h4>We obtained data on all cancer registrations from 1996 to 2008 for Leicester with ethnicity obtained by linkage to the Hospital Episodes Statistics database. Age-standardised incidence rates were calculated for childhood cancers in Indians and Whites as well as rate ratios, adjusted for age.<h4>Results</h4>There were 33 cancers registered among Indian children and 39 among White children. The incidence rate for Indians was greater compared to Whites for all cancers combined (RR 1.82 (95% CI 1.14 to 2.89); p = 0.01), with some evidence of increased risk of leukaemia (RR 2.20 (0.95 to 5.07); p = 0.07), lymphoma (RR 3.96 (0.99 to 15.84); p = 0.04) and central nervous system tumours (RR 2.70 (1.00 to 7.26); p = 0.05). Rates were also higher in British Indian children compared to children in India.<h4>Conclusions</h4>British Indian children in Leicester had an increased risk of developing cancer compared to White children, largely due to a higher incidence of central nervous system and haematological malignancies.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061881&type=printable |
| spellingShingle | Shameq Sayeed Isobel Barnes Benjamin J Cairns Alexander Finlayson Raghib Ali Childhood cancer incidence in British Indians & Whites in Leicester, 1996-2008. PLoS ONE |
| title | Childhood cancer incidence in British Indians & Whites in Leicester, 1996-2008. |
| title_full | Childhood cancer incidence in British Indians & Whites in Leicester, 1996-2008. |
| title_fullStr | Childhood cancer incidence in British Indians & Whites in Leicester, 1996-2008. |
| title_full_unstemmed | Childhood cancer incidence in British Indians & Whites in Leicester, 1996-2008. |
| title_short | Childhood cancer incidence in British Indians & Whites in Leicester, 1996-2008. |
| title_sort | childhood cancer incidence in british indians amp whites in leicester 1996 2008 |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061881&type=printable |
| work_keys_str_mv | AT shameqsayeed childhoodcancerincidenceinbritishindiansampwhitesinleicester19962008 AT isobelbarnes childhoodcancerincidenceinbritishindiansampwhitesinleicester19962008 AT benjaminjcairns childhoodcancerincidenceinbritishindiansampwhitesinleicester19962008 AT alexanderfinlayson childhoodcancerincidenceinbritishindiansampwhitesinleicester19962008 AT raghibali childhoodcancerincidenceinbritishindiansampwhitesinleicester19962008 |