Indoleamine 2,3-dioxygenase-1 expression in non-small-cell lung cancer: analyses of prevalence, clinical correlations and prognostic impact in 2 large patient cohorts

BackgroundIndoleamine 2,3-dioxygenase-1 (IDO-1) is a cytosolic enzyme involved in the catabolism of tryptophan. IDO-1-related immune suppression is due to decreased tryptophan availability and to the generation of tryptophan metabolites, culminating in substantial suppression of T-lymphocytes. Here...

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Main Authors:	Francesco Agustoni, Hui Yu, Kim Ellison, Derek Smith, Paul Mitchell, Gareth Rivalland, Rafal Dziadziuszko, Dexiang Gao, Shengxiang Ren, Christopher J. Rivard, Inigo San Millan, Salvatore Corallo, Paolo Pedrazzoli, Fred R. Hirsch
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Series:	Frontiers in Immunology
Subjects:	non-small cell lung cancer indoleamine 2 3-dioxygenase-1 immunotherapy immunohistochemistry biomarker
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1586782/full
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Indoleamine 2,3-dioxygenase-1 expression in non-small-cell lung cancer: analyses of prevalence, clinical correlations and prognostic impact in 2 large patient cohorts

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