Unravelling neutropenic enterocolitis: insights from gut microbiota, and intestinal barrier analyses

Unravelling neutropenic enterocolitis: insights from gut microbiota, and intestinal barrier analyses

Abstract Background Neutropenic enterocolitis (NE) is a severe digestive complication of chemotherapy, primarily affecting patients with acute myeloid leukemia (AML). We hypothesized that NE is linked to intestinal barrier dysfunction and gut dysbiosis. Methods Sixty-five AML patients undergoing ind...

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Main Authors: Natacha Kapandji, Maud Salmona, Anaïs Lemoine, Guillaume Ulmann, Julien Calderaro, Brigitte Roche, Nathalie Kapel, Lucie Biard, Etienne Lengline, Jérôme Le Goff, Christophe Rodriguez, Muriel Thomas, Lara Zafrani
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Experimental Hematology & Oncology
Subjects:
Neutropenic enterocolitis
Gut microbiota
Interleukin-6 family
Citrulline
Butyrate
Online Access:https://doi.org/10.1186/s40164-025-00661-4
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