The relationship between thigh circumference and sarcopenia in Chinese community-dwelling elderly aged ≥60 years
Background: There has been a growing body of research demonstrating that thigh circumference is closely associated with the development of various chronic disease. However, limited evidence has been obtained regarding the relationship between thigh circumference and sarcopenia. Objective: The aim of...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024153534 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850250224586457088 |
|---|---|
| author | Zhiwei Zhang Qianwen Yang Panpan He Xiaoming Liu Xuejiao Zeng Xueqian Mao Xueyi Jin Ying Hu Lipeng Jing |
| author_facet | Zhiwei Zhang Qianwen Yang Panpan He Xiaoming Liu Xuejiao Zeng Xueqian Mao Xueyi Jin Ying Hu Lipeng Jing |
| author_sort | Zhiwei Zhang |
| collection | DOAJ |
| description | Background: There has been a growing body of research demonstrating that thigh circumference is closely associated with the development of various chronic disease. However, limited evidence has been obtained regarding the relationship between thigh circumference and sarcopenia. Objective: The aim of this study was to investigate the relationship between thigh circumference and sarcopenia, and explore the potential role of thigh circumference for sarcopenia screening among community-dwelling older adults. Methods: The investigation was carried out in six rural communities located in northwestern China with participants aged ≥60 years old. We collected variables related to sarcopenia, including function, muscle mass, and strength. The thigh circumference was categorized into four groups based on quartiles, with the first quartile (≤46.65 cm); the second quartile (46.66–48.50 cm); the third quartile (48.51–50.55 cm); and the fourth quartile (>50.55 cm). The associations and screening effect were estimated with multivariate logistics regression and ROC curves. Results: Of the 1000 participants aged 70.72 ± 4.68 years. Compared with the first quartile (≤46.65 cm), the odds ratios for the second, third, and fourth quartiles of thigh circumference were 0.465 (95%CI: 0.281–0.770, p = 0.003), 0.199 (95%CI: 0.097–0.407, p < 0.001), and 0.059 (95%CI: 0.016–0.220, p < 0.001), respectively. The regression results were consistent across different sexes. The AUC and cutoff values of thigh circumference for sarcopenia were 0.873 (95 % CI 0.836–0.909, p < 0.001) and 48.83 cm for men and 0.861 (95 % CI 0.822–0.900, p < 0.001) and 46.78 cm for women. There was a positive correlation between thigh circumference and skeletal muscle mass (r = 0.747, p < 0.001), hand grip strength (r = 0.337, p < 0.001), and gait speed (r = 0.142, p < 0.001), while a negative correlation was observed with five-times-sit-to-stand test (r = −0.073, p = 0.021). Conclusion: There was a negative correlation between thigh circumference and sarcopenia, suggesting that thigh circumference may serve as a potential useful indicator for sarcopenia screening in the elderly. |
| format | Article |
| id | doaj-art-46872426ac4a4efca16af1ee02b20ac3 |
| institution | OA Journals |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-46872426ac4a4efca16af1ee02b20ac32025-08-20T01:58:16ZengElsevierHeliyon2405-84402024-12-011024e3932210.1016/j.heliyon.2024.e39322The relationship between thigh circumference and sarcopenia in Chinese community-dwelling elderly aged ≥60 yearsZhiwei Zhang0Qianwen Yang1Panpan He2Xiaoming Liu3Xuejiao Zeng4Xueqian Mao5Xueyi Jin6Ying Hu7Lipeng Jing8Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu Province, ChinaInstitute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu Province, ChinaInstitute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu Province, ChinaInstitute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu Province, ChinaInstitute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu Province, ChinaInstitute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu Province, ChinaInstitute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu Province, ChinaInstitute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu Province, ChinaCorresponding author. Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, 199 Donggang West Road, Lanzhou, Gansu Province, 730000, China.; Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu Province, ChinaBackground: There has been a growing body of research demonstrating that thigh circumference is closely associated with the development of various chronic disease. However, limited evidence has been obtained regarding the relationship between thigh circumference and sarcopenia. Objective: The aim of this study was to investigate the relationship between thigh circumference and sarcopenia, and explore the potential role of thigh circumference for sarcopenia screening among community-dwelling older adults. Methods: The investigation was carried out in six rural communities located in northwestern China with participants aged ≥60 years old. We collected variables related to sarcopenia, including function, muscle mass, and strength. The thigh circumference was categorized into four groups based on quartiles, with the first quartile (≤46.65 cm); the second quartile (46.66–48.50 cm); the third quartile (48.51–50.55 cm); and the fourth quartile (>50.55 cm). The associations and screening effect were estimated with multivariate logistics regression and ROC curves. Results: Of the 1000 participants aged 70.72 ± 4.68 years. Compared with the first quartile (≤46.65 cm), the odds ratios for the second, third, and fourth quartiles of thigh circumference were 0.465 (95%CI: 0.281–0.770, p = 0.003), 0.199 (95%CI: 0.097–0.407, p < 0.001), and 0.059 (95%CI: 0.016–0.220, p < 0.001), respectively. The regression results were consistent across different sexes. The AUC and cutoff values of thigh circumference for sarcopenia were 0.873 (95 % CI 0.836–0.909, p < 0.001) and 48.83 cm for men and 0.861 (95 % CI 0.822–0.900, p < 0.001) and 46.78 cm for women. There was a positive correlation between thigh circumference and skeletal muscle mass (r = 0.747, p < 0.001), hand grip strength (r = 0.337, p < 0.001), and gait speed (r = 0.142, p < 0.001), while a negative correlation was observed with five-times-sit-to-stand test (r = −0.073, p = 0.021). Conclusion: There was a negative correlation between thigh circumference and sarcopenia, suggesting that thigh circumference may serve as a potential useful indicator for sarcopenia screening in the elderly.http://www.sciencedirect.com/science/article/pii/S2405844024153534Thigh circumferenceSarcopeniaMuscle massMuscle strengthPhysical performance |
| spellingShingle | Zhiwei Zhang Qianwen Yang Panpan He Xiaoming Liu Xuejiao Zeng Xueqian Mao Xueyi Jin Ying Hu Lipeng Jing The relationship between thigh circumference and sarcopenia in Chinese community-dwelling elderly aged ≥60 years Heliyon Thigh circumference Sarcopenia Muscle mass Muscle strength Physical performance |
| title | The relationship between thigh circumference and sarcopenia in Chinese community-dwelling elderly aged ≥60 years |
| title_full | The relationship between thigh circumference and sarcopenia in Chinese community-dwelling elderly aged ≥60 years |
| title_fullStr | The relationship between thigh circumference and sarcopenia in Chinese community-dwelling elderly aged ≥60 years |
| title_full_unstemmed | The relationship between thigh circumference and sarcopenia in Chinese community-dwelling elderly aged ≥60 years |
| title_short | The relationship between thigh circumference and sarcopenia in Chinese community-dwelling elderly aged ≥60 years |
| title_sort | relationship between thigh circumference and sarcopenia in chinese community dwelling elderly aged ≥60 years |
| topic | Thigh circumference Sarcopenia Muscle mass Muscle strength Physical performance |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024153534 |
| work_keys_str_mv | AT zhiweizhang therelationshipbetweenthighcircumferenceandsarcopeniainchinesecommunitydwellingelderlyaged60years AT qianwenyang therelationshipbetweenthighcircumferenceandsarcopeniainchinesecommunitydwellingelderlyaged60years AT panpanhe therelationshipbetweenthighcircumferenceandsarcopeniainchinesecommunitydwellingelderlyaged60years AT xiaomingliu therelationshipbetweenthighcircumferenceandsarcopeniainchinesecommunitydwellingelderlyaged60years AT xuejiaozeng therelationshipbetweenthighcircumferenceandsarcopeniainchinesecommunitydwellingelderlyaged60years AT xueqianmao therelationshipbetweenthighcircumferenceandsarcopeniainchinesecommunitydwellingelderlyaged60years AT xueyijin therelationshipbetweenthighcircumferenceandsarcopeniainchinesecommunitydwellingelderlyaged60years AT yinghu therelationshipbetweenthighcircumferenceandsarcopeniainchinesecommunitydwellingelderlyaged60years AT lipengjing therelationshipbetweenthighcircumferenceandsarcopeniainchinesecommunitydwellingelderlyaged60years AT zhiweizhang relationshipbetweenthighcircumferenceandsarcopeniainchinesecommunitydwellingelderlyaged60years AT qianwenyang relationshipbetweenthighcircumferenceandsarcopeniainchinesecommunitydwellingelderlyaged60years AT panpanhe relationshipbetweenthighcircumferenceandsarcopeniainchinesecommunitydwellingelderlyaged60years AT xiaomingliu relationshipbetweenthighcircumferenceandsarcopeniainchinesecommunitydwellingelderlyaged60years AT xuejiaozeng relationshipbetweenthighcircumferenceandsarcopeniainchinesecommunitydwellingelderlyaged60years AT xueqianmao relationshipbetweenthighcircumferenceandsarcopeniainchinesecommunitydwellingelderlyaged60years AT xueyijin relationshipbetweenthighcircumferenceandsarcopeniainchinesecommunitydwellingelderlyaged60years AT yinghu relationshipbetweenthighcircumferenceandsarcopeniainchinesecommunitydwellingelderlyaged60years AT lipengjing relationshipbetweenthighcircumferenceandsarcopeniainchinesecommunitydwellingelderlyaged60years |