Characterization, Diagnosis, and Multidisciplinary Management of Late-Onset Wilms Tumor/Nephroblastoma: Case Report and Literature Review
Introduction: Wilms tumor, or nephroblastoma, is a renal neoplasm that originates from alterations in renal embryogenesis. It predominantly affects pediatric patients (only 3% occur in adults) and has a significant genetic component, being associated with syndromes such as Denys-Drash, Perlman, and...
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| Format: | Article |
| Language: | Spanish |
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Universidad de Antioquia
2025-07-01
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| Series: | Iatreia |
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| Online Access: | https://revistas.udea.edu.co/index.php/iatreia/article/view/352625 |
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| author | Castaño Morales, Miguel Angel Castaño Morales, Jhonny Alexander Jaramillo Alvarez, Juan Felipe Gallegos Tellez, Erika Patricia Corrales Cruz, Lina Maria |
| author_facet | Castaño Morales, Miguel Angel Castaño Morales, Jhonny Alexander Jaramillo Alvarez, Juan Felipe Gallegos Tellez, Erika Patricia Corrales Cruz, Lina Maria |
| author_sort | Castaño Morales, Miguel Angel |
| collection | DOAJ |
| description | Introduction: Wilms tumor, or nephroblastoma, is a renal neoplasm that originates from alterations in renal embryogenesis. It predominantly affects pediatric patients (only 3% occur in adults) and has a significant genetic component, being associated with syndromes such as Denys-Drash, Perlman, and Beckwith-Wiedemann. The initial clinical presentation typically includes an abdominal mass (usually detected at advanced stages) with intermittent hematuria, and may involve adjacent organs.
Treatment: Management should be multimodal and multidisciplinary, with surgery, chemotherapy, and radiotherapy as the mainstays, their appropriateness and sequence determined according to staging protocols from the Children’s Oncology Group (COG) and the International Society of Pediatric Oncology (SIOP).
Case report: We present a case of Wilms tumor in an adult patient, describing clinical and paraclinical features, surgical approach, pathological studies performed, and selected chemotherapy and radiotherapy regimens. |
| format | Article |
| id | doaj-art-4686b683074c4899b6d3bc4898dbe95e |
| institution | Kabale University |
| issn | 0121-0793 2011-7965 |
| language | Spanish |
| publishDate | 2025-07-01 |
| publisher | Universidad de Antioquia |
| record_format | Article |
| series | Iatreia |
| spelling | doaj-art-4686b683074c4899b6d3bc4898dbe95e2025-08-20T03:32:55ZspaUniversidad de AntioquiaIatreia0121-07932011-79652025-07-0138356357310.17533/udea.iatreia.266Characterization, Diagnosis, and Multidisciplinary Management of Late-Onset Wilms Tumor/Nephroblastoma: Case Report and Literature ReviewCastaño Morales, Miguel Angel0https://orcid.org/0000-0002-8240-4740Castaño Morales, Jhonny Alexander1https://orcid.org/0000-0002-7607-8635Jaramillo Alvarez, Juan Felipe2https://orcid.org/0000-0001-8744-113XGallegos Tellez, Erika Patricia3https://orcid.org/0000-0003-0892-0373Corrales Cruz, Lina Maria 4https://orcid.org/0000-0003-1357-1526Universidad Pontificia Bolivariana, Medellín, ColombiaClinac, Envigado, ColombiaClínica Somer, Rionegro, ColombiaClinac, Envigado, ColombiaClinac, Envigado, ColombiaIntroduction: Wilms tumor, or nephroblastoma, is a renal neoplasm that originates from alterations in renal embryogenesis. It predominantly affects pediatric patients (only 3% occur in adults) and has a significant genetic component, being associated with syndromes such as Denys-Drash, Perlman, and Beckwith-Wiedemann. The initial clinical presentation typically includes an abdominal mass (usually detected at advanced stages) with intermittent hematuria, and may involve adjacent organs. Treatment: Management should be multimodal and multidisciplinary, with surgery, chemotherapy, and radiotherapy as the mainstays, their appropriateness and sequence determined according to staging protocols from the Children’s Oncology Group (COG) and the International Society of Pediatric Oncology (SIOP). Case report: We present a case of Wilms tumor in an adult patient, describing clinical and paraclinical features, surgical approach, pathological studies performed, and selected chemotherapy and radiotherapy regimens.https://revistas.udea.edu.co/index.php/iatreia/article/view/352625adultcase reportscombined modality therapykidney neoplasmswilms tumor |
| spellingShingle | Castaño Morales, Miguel Angel Castaño Morales, Jhonny Alexander Jaramillo Alvarez, Juan Felipe Gallegos Tellez, Erika Patricia Corrales Cruz, Lina Maria Characterization, Diagnosis, and Multidisciplinary Management of Late-Onset Wilms Tumor/Nephroblastoma: Case Report and Literature Review Iatreia adult case reports combined modality therapy kidney neoplasms wilms tumor |
| title | Characterization, Diagnosis, and Multidisciplinary Management of Late-Onset Wilms Tumor/Nephroblastoma: Case Report and Literature Review |
| title_full | Characterization, Diagnosis, and Multidisciplinary Management of Late-Onset Wilms Tumor/Nephroblastoma: Case Report and Literature Review |
| title_fullStr | Characterization, Diagnosis, and Multidisciplinary Management of Late-Onset Wilms Tumor/Nephroblastoma: Case Report and Literature Review |
| title_full_unstemmed | Characterization, Diagnosis, and Multidisciplinary Management of Late-Onset Wilms Tumor/Nephroblastoma: Case Report and Literature Review |
| title_short | Characterization, Diagnosis, and Multidisciplinary Management of Late-Onset Wilms Tumor/Nephroblastoma: Case Report and Literature Review |
| title_sort | characterization diagnosis and multidisciplinary management of late onset wilms tumor nephroblastoma case report and literature review |
| topic | adult case reports combined modality therapy kidney neoplasms wilms tumor |
| url | https://revistas.udea.edu.co/index.php/iatreia/article/view/352625 |
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