Impaired Hepatitis B and COVID-19 vaccination responses show strong concordance in hemodialysis patients with end stage renal disease
Abstract Background Patients with end stage renal disease (ESRD) undergoing hemodialysis are at increased risk for infection and impaired vaccination responses. We analyzed overlap and influencing factors of vaccination responses against severe acute respiratory syndrome corona virus disease 2 (SARS...
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BMC
2025-01-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02274-3 |
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| author | Karsten Lürken Anna Meinecke Luis A. Manthey Anne Cossmann Metodi V. Stankov Frank Klawonn Anna Zychlinsky Scharff Sandra Steffens Alexandra Dopfer-Jablonka Frank Müller Georg M. N. Behrens Christine Happle |
| author_facet | Karsten Lürken Anna Meinecke Luis A. Manthey Anne Cossmann Metodi V. Stankov Frank Klawonn Anna Zychlinsky Scharff Sandra Steffens Alexandra Dopfer-Jablonka Frank Müller Georg M. N. Behrens Christine Happle |
| author_sort | Karsten Lürken |
| collection | DOAJ |
| description | Abstract Background Patients with end stage renal disease (ESRD) undergoing hemodialysis are at increased risk for infection and impaired vaccination responses. We analyzed overlap and influencing factors of vaccination responses against severe acute respiratory syndrome corona virus disease 2 (SARS-CoV-2) and Hepatitis B virus (HBV). Methods SARS-CoV-2 and HBV vaccination response was assessed in a cohort of German ESRD hemodialysis patients. Anti-HBs- and SARS-CoV-2 anti-S-IgG were analyzed by ELISA. Demographic and clinical data were extracted from clinical files. Results Sixty-four patients with complete information on HBV and SARS-CoV-2 vaccination responses were included. More than one-third (35.4%) of non-responders upon HBV vaccination were identified. Unresponsiveness after HBV and poor response after SARS-CoV-2 vaccination showed strong overlap, and overall, 70.3% of patients were classified into concordant HBV/SARS vaccination response groups. HBV vaccination non-responsiveness, but not poor SARS-CoV-2 post-vaccination immunity was associated with obesity, while poor SARS-CoV-2 vaccination responses were associated increased age. Conclusion Our findings confirm previous reports on impaired vaccination response in hemodialysis patients and show that post-vaccination humoral responses against SARS-CoV-2 and HBV display strong overlap in this vulnerable patient group. These results may help to adapt vaccination strategies in this highly vulnerable population. Trial registration: German Clinical Trial Registry, DRKS00021152. |
| format | Article |
| id | doaj-art-4685581a44e04077aca66bdee519ea85 |
| institution | Kabale University |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-4685581a44e04077aca66bdee519ea852025-01-19T12:14:52ZengBMCEuropean Journal of Medical Research2047-783X2025-01-013011810.1186/s40001-025-02274-3Impaired Hepatitis B and COVID-19 vaccination responses show strong concordance in hemodialysis patients with end stage renal diseaseKarsten Lürken0Anna Meinecke1Luis A. Manthey2Anne Cossmann3Metodi V. Stankov4Frank Klawonn5Anna Zychlinsky Scharff6Sandra Steffens7Alexandra Dopfer-Jablonka8Frank Müller9Georg M. N. Behrens10Christine Happle11Dialysis Centre EickenhofDepartment of Rheumatology and Immunology, Hannover Medical SchoolDepartment of Rheumatology and Immunology, Hannover Medical SchoolDialysis Centre EickenhofDepartment of Rheumatology and Immunology, Hannover Medical SchoolInstitute of Information Engineering, Ostfalia University of Applied SciencesDepartment of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical SchoolDepartment of Rheumatology and Immunology, Hannover Medical SchoolDepartment of Rheumatology and Immunology, Hannover Medical SchoolDepartment of General Practice, University Medical Center GöttingenDepartment of Rheumatology and Immunology, Hannover Medical SchoolDepartment of Rheumatology and Immunology, Hannover Medical SchoolAbstract Background Patients with end stage renal disease (ESRD) undergoing hemodialysis are at increased risk for infection and impaired vaccination responses. We analyzed overlap and influencing factors of vaccination responses against severe acute respiratory syndrome corona virus disease 2 (SARS-CoV-2) and Hepatitis B virus (HBV). Methods SARS-CoV-2 and HBV vaccination response was assessed in a cohort of German ESRD hemodialysis patients. Anti-HBs- and SARS-CoV-2 anti-S-IgG were analyzed by ELISA. Demographic and clinical data were extracted from clinical files. Results Sixty-four patients with complete information on HBV and SARS-CoV-2 vaccination responses were included. More than one-third (35.4%) of non-responders upon HBV vaccination were identified. Unresponsiveness after HBV and poor response after SARS-CoV-2 vaccination showed strong overlap, and overall, 70.3% of patients were classified into concordant HBV/SARS vaccination response groups. HBV vaccination non-responsiveness, but not poor SARS-CoV-2 post-vaccination immunity was associated with obesity, while poor SARS-CoV-2 vaccination responses were associated increased age. Conclusion Our findings confirm previous reports on impaired vaccination response in hemodialysis patients and show that post-vaccination humoral responses against SARS-CoV-2 and HBV display strong overlap in this vulnerable patient group. These results may help to adapt vaccination strategies in this highly vulnerable population. Trial registration: German Clinical Trial Registry, DRKS00021152.https://doi.org/10.1186/s40001-025-02274-3HemodialysisHBVSARS-CoV-2Vaccination response |
| spellingShingle | Karsten Lürken Anna Meinecke Luis A. Manthey Anne Cossmann Metodi V. Stankov Frank Klawonn Anna Zychlinsky Scharff Sandra Steffens Alexandra Dopfer-Jablonka Frank Müller Georg M. N. Behrens Christine Happle Impaired Hepatitis B and COVID-19 vaccination responses show strong concordance in hemodialysis patients with end stage renal disease European Journal of Medical Research Hemodialysis HBV SARS-CoV-2 Vaccination response |
| title | Impaired Hepatitis B and COVID-19 vaccination responses show strong concordance in hemodialysis patients with end stage renal disease |
| title_full | Impaired Hepatitis B and COVID-19 vaccination responses show strong concordance in hemodialysis patients with end stage renal disease |
| title_fullStr | Impaired Hepatitis B and COVID-19 vaccination responses show strong concordance in hemodialysis patients with end stage renal disease |
| title_full_unstemmed | Impaired Hepatitis B and COVID-19 vaccination responses show strong concordance in hemodialysis patients with end stage renal disease |
| title_short | Impaired Hepatitis B and COVID-19 vaccination responses show strong concordance in hemodialysis patients with end stage renal disease |
| title_sort | impaired hepatitis b and covid 19 vaccination responses show strong concordance in hemodialysis patients with end stage renal disease |
| topic | Hemodialysis HBV SARS-CoV-2 Vaccination response |
| url | https://doi.org/10.1186/s40001-025-02274-3 |
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