Serum Ferritin as a Predictor of Hospital Mortality in Critically Ill COVID-19 Patients
Serum ferritin levels increase in severe COVID-19 patients. However, few data correlating the sensitivity and specificity of ferritin levels and mortality prediction in COVID-19 exist. The current study aims to investigate the sensitivity and specificity of ferritin for the prediction of mortality r...
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MDPI AG
2025-04-01
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| Series: | COVID |
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| Online Access: | https://www.mdpi.com/2673-8112/5/4/60 |
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| author | Ferhat Soykan Demet Bolukbasi Erol Toy Nazan Has Selmi Asiye Yavuz Behiye Deniz Kosovali Nevzat Mehmet Mutlu Aliye Bastug Derya Gokcinar Belgin Akan Seval Izdes |
| author_facet | Ferhat Soykan Demet Bolukbasi Erol Toy Nazan Has Selmi Asiye Yavuz Behiye Deniz Kosovali Nevzat Mehmet Mutlu Aliye Bastug Derya Gokcinar Belgin Akan Seval Izdes |
| author_sort | Ferhat Soykan |
| collection | DOAJ |
| description | Serum ferritin levels increase in severe COVID-19 patients. However, few data correlating the sensitivity and specificity of ferritin levels and mortality prediction in COVID-19 exist. The current study aims to investigate the sensitivity and specificity of ferritin for the prediction of mortality risks relative to COVID-19. Retrospectively, critically ill COVID-19 patients admitted to the general intensive care unit (ICU) of Ankara Bilkent City Hospital, Türkiye, were examined. The median baseline ferritin level in the survivor group was 184.7 µg/L (90.1–430.7), while it was 297.0 µg/L (150.3–851.3) in the deceased group (<i>p</i> = 0.001). The median maximum ferritin in the survivor group was 486.6 µg/L (187.9–1020.0), while it was 1456.7 µg/L (578.5–4388.1) in the deceased group (<i>p</i> < 0.001). In the receiver operating characteristic (ROC) curve analysis, the cut-off baseline ferritin value was 201.5 µg/L for the prediction of mortality (area under the curve [AUC] = 0.615, <i>p</i> < 0.001, 95% Confidence interval [CI]: 0.557–0.671). Baseline ferritin levels were associated with increased in-hospital mortality (<i>p</i> < 0.001, odds ratio: 2.347, 95% CI: 1.5–3.7). Baseline ferritin exhibited 66% sensitivity and 54.2% specificity in predicting mortality. The maximum ferritin cut-off value was 878.6 µg/L (AUC = 0.754, <i>p</i> < 0.001, 95% CI: 0.701–0.802), exhibiting 68% sensitivity and 73.2% specificity for mortality prediction. Ferritin has a moderately effective prediction potential for mortality in COVID-19 patients admitted to the ICU. |
| format | Article |
| id | doaj-art-4681d395a7f544c8a79d2ce2274c2b99 |
| institution | DOAJ |
| issn | 2673-8112 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
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| series | COVID |
| spelling | doaj-art-4681d395a7f544c8a79d2ce2274c2b992025-08-20T03:13:57ZengMDPI AGCOVID2673-81122025-04-01546010.3390/covid5040060Serum Ferritin as a Predictor of Hospital Mortality in Critically Ill COVID-19 PatientsFerhat Soykan0Demet Bolukbasi1Erol Toy2Nazan Has Selmi3Asiye Yavuz4Behiye Deniz Kosovali5Nevzat Mehmet Mutlu6Aliye Bastug7Derya Gokcinar8Belgin Akan9Seval Izdes10Department of Critical Care, Ankara Bilkent City Hospital, 06800 Ankara, TürkiyeDepartment of Critical Care, Ankara Bilkent City Hospital, 06800 Ankara, TürkiyeDepartment of Critical Care, Ankara Bilkent City Hospital, 06800 Ankara, TürkiyeDepartment of Critical Care, Ankara Bilkent City Hospital, 06800 Ankara, TürkiyeDepartment of Critical Care, Ankara Bilkent City Hospital, 06800 Ankara, TürkiyeDepartment of Critical Care, Ankara Bilkent City Hospital, 06800 Ankara, TürkiyeDepartment of Critical Care, Ankara Bilkent City Hospital, 06800 Ankara, TürkiyeDepartment of Critical Care, Ankara Bilkent City Hospital, 06800 Ankara, TürkiyeDepartment of Critical Care, Ankara Bilkent City Hospital, 06800 Ankara, TürkiyeDepartment of Critical Care, Ankara Bilkent City Hospital, 06800 Ankara, TürkiyeDepartment of Critical Care, Ankara Bilkent City Hospital, 06800 Ankara, TürkiyeSerum ferritin levels increase in severe COVID-19 patients. However, few data correlating the sensitivity and specificity of ferritin levels and mortality prediction in COVID-19 exist. The current study aims to investigate the sensitivity and specificity of ferritin for the prediction of mortality risks relative to COVID-19. Retrospectively, critically ill COVID-19 patients admitted to the general intensive care unit (ICU) of Ankara Bilkent City Hospital, Türkiye, were examined. The median baseline ferritin level in the survivor group was 184.7 µg/L (90.1–430.7), while it was 297.0 µg/L (150.3–851.3) in the deceased group (<i>p</i> = 0.001). The median maximum ferritin in the survivor group was 486.6 µg/L (187.9–1020.0), while it was 1456.7 µg/L (578.5–4388.1) in the deceased group (<i>p</i> < 0.001). In the receiver operating characteristic (ROC) curve analysis, the cut-off baseline ferritin value was 201.5 µg/L for the prediction of mortality (area under the curve [AUC] = 0.615, <i>p</i> < 0.001, 95% Confidence interval [CI]: 0.557–0.671). Baseline ferritin levels were associated with increased in-hospital mortality (<i>p</i> < 0.001, odds ratio: 2.347, 95% CI: 1.5–3.7). Baseline ferritin exhibited 66% sensitivity and 54.2% specificity in predicting mortality. The maximum ferritin cut-off value was 878.6 µg/L (AUC = 0.754, <i>p</i> < 0.001, 95% CI: 0.701–0.802), exhibiting 68% sensitivity and 73.2% specificity for mortality prediction. Ferritin has a moderately effective prediction potential for mortality in COVID-19 patients admitted to the ICU.https://www.mdpi.com/2673-8112/5/4/60COVID-19ferritinsintensive care unitsmortalitySARS-CoV-2 |
| spellingShingle | Ferhat Soykan Demet Bolukbasi Erol Toy Nazan Has Selmi Asiye Yavuz Behiye Deniz Kosovali Nevzat Mehmet Mutlu Aliye Bastug Derya Gokcinar Belgin Akan Seval Izdes Serum Ferritin as a Predictor of Hospital Mortality in Critically Ill COVID-19 Patients COVID COVID-19 ferritins intensive care units mortality SARS-CoV-2 |
| title | Serum Ferritin as a Predictor of Hospital Mortality in Critically Ill COVID-19 Patients |
| title_full | Serum Ferritin as a Predictor of Hospital Mortality in Critically Ill COVID-19 Patients |
| title_fullStr | Serum Ferritin as a Predictor of Hospital Mortality in Critically Ill COVID-19 Patients |
| title_full_unstemmed | Serum Ferritin as a Predictor of Hospital Mortality in Critically Ill COVID-19 Patients |
| title_short | Serum Ferritin as a Predictor of Hospital Mortality in Critically Ill COVID-19 Patients |
| title_sort | serum ferritin as a predictor of hospital mortality in critically ill covid 19 patients |
| topic | COVID-19 ferritins intensive care units mortality SARS-CoV-2 |
| url | https://www.mdpi.com/2673-8112/5/4/60 |
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