Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses
Angiostrongylus cantonensis is a nematode parasite that causes eosinophilic meningoencephalitis in humans. Disease presents following the ingestion of third-stage larvae residing in the intermediate mollusk host and disease manifests as an acute inflammation of the meninges characterized by eosinoph...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/512097 |
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| _version_ | 1832554145622523904 |
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| author | Alessandra L. Morassutti Carlos Graeff-Teixeira |
| author_facet | Alessandra L. Morassutti Carlos Graeff-Teixeira |
| author_sort | Alessandra L. Morassutti |
| collection | DOAJ |
| description | Angiostrongylus cantonensis is a nematode parasite that causes eosinophilic meningoencephalitis in humans. Disease presents following the ingestion of third-stage larvae residing in the intermediate mollusk host and disease manifests as an acute inflammation of the meninges characterized by eosinophil infiltrates which release a battery of proinflammatory and cytotoxic agents in response to the pathogen. As a mechanism of neutralizing these host defenses, A. cantonensis expresses different molecules with immunomodulatory properties that are excreted or secreted (ES). In this paper we discuss the role of ES proteins on disease exacerbation and their potential use as therapeutic targets. |
| format | Article |
| id | doaj-art-467f4373f1c0479ba8820320dbd329f5 |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-467f4373f1c0479ba8820320dbd329f52025-02-03T05:52:14ZengWileyInternational Journal of Inflammation2090-80402042-00992012-01-01201210.1155/2012/512097512097Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host DefensesAlessandra L. Morassutti0Carlos Graeff-Teixeira1Laboratório de Biologia Parasitária Faculdade de Biociências e Laboratório de Parasitologia Molecular Instituto de Pesquisas Biomédicas Pontifícia Universidade do Rio Grande do Sul (PUCRS), 90690-900 Porto Alegre, RS, BrazilLaboratório de Biologia Parasitária Faculdade de Biociências e Laboratório de Parasitologia Molecular Instituto de Pesquisas Biomédicas Pontifícia Universidade do Rio Grande do Sul (PUCRS), 90690-900 Porto Alegre, RS, BrazilAngiostrongylus cantonensis is a nematode parasite that causes eosinophilic meningoencephalitis in humans. Disease presents following the ingestion of third-stage larvae residing in the intermediate mollusk host and disease manifests as an acute inflammation of the meninges characterized by eosinophil infiltrates which release a battery of proinflammatory and cytotoxic agents in response to the pathogen. As a mechanism of neutralizing these host defenses, A. cantonensis expresses different molecules with immunomodulatory properties that are excreted or secreted (ES). In this paper we discuss the role of ES proteins on disease exacerbation and their potential use as therapeutic targets.http://dx.doi.org/10.1155/2012/512097 |
| spellingShingle | Alessandra L. Morassutti Carlos Graeff-Teixeira Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses International Journal of Inflammation |
| title | Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses |
| title_full | Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses |
| title_fullStr | Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses |
| title_full_unstemmed | Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses |
| title_short | Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses |
| title_sort | interface molecules of angiostrongylus cantonensis their role in parasite survival and modulation of host defenses |
| url | http://dx.doi.org/10.1155/2012/512097 |
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