Serum leptin and its relation to body composition, puberty, and metabolism in severe obesity
Childhood severe obesity (SO) is a growing public health concern. Leptin (LEP) and its biologically active fraction (BioLEP) play a key role in energy balance and body mass regulation. Understanding their relationship with anthropometric and metabolic parameters is crucial for improving SO treatment...
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Bioscientifica
2025-07-01
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| Series: | Endocrine Connections |
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| Online Access: | https://ec.bioscientifica.com/view/journals/ec/14/7/EC-25-0194.xml |
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| author | Sabina Galiniak Marek Biesiadecki Rafał Podgórski Natalia Dąbek Ewa Gramatyka-Drążek Ewelina Gaweł Michael B Ranke Bertram Flehmig Martin Wabitsch Stephanie Brandt Elżbieta Petriczko Małgorzata Wójcik Ewa Małecka-Tendera Mirosław Bik-Multanowski Agnieszka Zachurzok Artur Mazur |
| author_facet | Sabina Galiniak Marek Biesiadecki Rafał Podgórski Natalia Dąbek Ewa Gramatyka-Drążek Ewelina Gaweł Michael B Ranke Bertram Flehmig Martin Wabitsch Stephanie Brandt Elżbieta Petriczko Małgorzata Wójcik Ewa Małecka-Tendera Mirosław Bik-Multanowski Agnieszka Zachurzok Artur Mazur |
| author_sort | Sabina Galiniak |
| collection | DOAJ |
| description | Childhood severe obesity (SO) is a growing public health concern. Leptin (LEP) and its biologically active fraction (BioLEP) play a key role in energy balance and body mass regulation. Understanding their relationship with anthropometric and metabolic parameters is crucial for improving SO treatment. This study analyzed total LEP, BioLEP, and the BioLEP/LEP ratio in children with SO and their associations with body composition, lipid profile, and pubertal development. The study included 461 children (245 girls and 216 boys) aged 0–19 years with SO. Anthropometric parameters, metabolic indices, and pubertal stages (Tanner scale) were assessed. LEP and BioLEP concentrations were measured using ELISA, and the BioLEP/LEP ratio was calculated. The median LEP concentration was 56.53 ng/mL, and BioLEP was 53.66 ng/mL, with a BioLEP/LEP ratio of 0.94. Girls had significantly higher LEP (64.40 vs 49.66 ng/mL, P < 0.001) and BioLEP (59.90 vs 46.93 ng/mL, P < 0.001) than boys. LEP and BioLEP correlated positively with BMI, waist and hip circumference, and fat mass percentage, while negatively with waist-to-hip ratio and fat-free mass. The BioLEP/LEP ratio correlated positively with insulin and lipid profile parameters (total cholesterol, HDL, and triglycerides). LEP and BioLEP play a significant role in SO, particularly in fat mass regulation. The BioLEP/LEP ratio is more closely linked to lipid metabolism. These findings provide insights into the hormonal and metabolic profile of SO, supporting targeted diagnostic and therapeutic approaches. |
| format | Article |
| id | doaj-art-467542ee6ab94f92bd0c8e131952fef5 |
| institution | Kabale University |
| issn | 2049-3614 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj-art-467542ee6ab94f92bd0c8e131952fef52025-08-20T03:28:18ZengBioscientificaEndocrine Connections2049-36142025-07-0114710.1530/EC-25-01941Serum leptin and its relation to body composition, puberty, and metabolism in severe obesitySabina Galiniak0Marek Biesiadecki1Rafał Podgórski2Natalia Dąbek3Ewa Gramatyka-Drążek4Ewelina Gaweł5Michael B Ranke6Bertram Flehmig7Martin Wabitsch8Stephanie Brandt9Elżbieta Petriczko10Małgorzata Wójcik11Ewa Małecka-Tendera12Mirosław Bik-Multanowski13Agnieszka Zachurzok14Artur Mazur15Faculty of Medicine, Medical College, University of Rzeszów, Rzeszów, PolandFaculty of Medicine, Medical College, University of Rzeszów, Rzeszów, PolandFaculty of Medicine, Medical College, University of Rzeszów, Rzeszów, PolandFaculty of Medicine, Medical College, University of Rzeszów, Rzeszów, PolandFaculty of Medicine, Medical College, University of Rzeszów, Rzeszów, PolandFaculty of Medicine, Medical College, University of Rzeszów, Rzeszów, PolandChildren’s Hospital, University of Tübingen, Tübingen, GermanyMediagnost GmbH, Reutlingen, GermanyDivision of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, Center for Rare Endocrine Diseases, Ulm, GermanyDivision of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, Center for Rare Endocrine Diseases, Ulm, GermanyDepartment of Pediatrics, Endocrinology, Diabetology, Metabolic Disorders and Cardiology of Developmental Age, Pomeranian Medical University, Szczecin, PolandDepartment of Pediatric and Adolescent Endocrinology, Pediatric Institute, Jagiellonian University Medical College, Cracow, PolandDepartment of Pediatrics and Pediatric Endocrinology, Medical University of Silesia, School of Medicine in Katowice, Katowice, PolandDepartment of Medical Genetics, Jagiellonian University Medical College, Cracow, PolandDepartment of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Zabrze, PolandFaculty of Medicine, Medical College, University of Rzeszów, Rzeszów, PolandChildhood severe obesity (SO) is a growing public health concern. Leptin (LEP) and its biologically active fraction (BioLEP) play a key role in energy balance and body mass regulation. Understanding their relationship with anthropometric and metabolic parameters is crucial for improving SO treatment. This study analyzed total LEP, BioLEP, and the BioLEP/LEP ratio in children with SO and their associations with body composition, lipid profile, and pubertal development. The study included 461 children (245 girls and 216 boys) aged 0–19 years with SO. Anthropometric parameters, metabolic indices, and pubertal stages (Tanner scale) were assessed. LEP and BioLEP concentrations were measured using ELISA, and the BioLEP/LEP ratio was calculated. The median LEP concentration was 56.53 ng/mL, and BioLEP was 53.66 ng/mL, with a BioLEP/LEP ratio of 0.94. Girls had significantly higher LEP (64.40 vs 49.66 ng/mL, P < 0.001) and BioLEP (59.90 vs 46.93 ng/mL, P < 0.001) than boys. LEP and BioLEP correlated positively with BMI, waist and hip circumference, and fat mass percentage, while negatively with waist-to-hip ratio and fat-free mass. The BioLEP/LEP ratio correlated positively with insulin and lipid profile parameters (total cholesterol, HDL, and triglycerides). LEP and BioLEP play a significant role in SO, particularly in fat mass regulation. The BioLEP/LEP ratio is more closely linked to lipid metabolism. These findings provide insights into the hormonal and metabolic profile of SO, supporting targeted diagnostic and therapeutic approaches.https://ec.bioscientifica.com/view/journals/ec/14/7/EC-25-0194.xmlsevere obesityleptinbiologically active leptinbody compositionlipid profile |
| spellingShingle | Sabina Galiniak Marek Biesiadecki Rafał Podgórski Natalia Dąbek Ewa Gramatyka-Drążek Ewelina Gaweł Michael B Ranke Bertram Flehmig Martin Wabitsch Stephanie Brandt Elżbieta Petriczko Małgorzata Wójcik Ewa Małecka-Tendera Mirosław Bik-Multanowski Agnieszka Zachurzok Artur Mazur Serum leptin and its relation to body composition, puberty, and metabolism in severe obesity Endocrine Connections severe obesity leptin biologically active leptin body composition lipid profile |
| title | Serum leptin and its relation to body composition, puberty, and metabolism in severe obesity |
| title_full | Serum leptin and its relation to body composition, puberty, and metabolism in severe obesity |
| title_fullStr | Serum leptin and its relation to body composition, puberty, and metabolism in severe obesity |
| title_full_unstemmed | Serum leptin and its relation to body composition, puberty, and metabolism in severe obesity |
| title_short | Serum leptin and its relation to body composition, puberty, and metabolism in severe obesity |
| title_sort | serum leptin and its relation to body composition puberty and metabolism in severe obesity |
| topic | severe obesity leptin biologically active leptin body composition lipid profile |
| url | https://ec.bioscientifica.com/view/journals/ec/14/7/EC-25-0194.xml |
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