Effects of curcumin supplementation on the severity of intra-abdominal adhesions in rats

Effects of curcumin supplementation on the severity of intra-abdominal adhesions in rats

ABSTRACT Purpose: To evaluate the effect of curcumin administered by gavage, on reducing intra-abdominal adhesions and attenuating the inflammatory process, assessed by a serum marker. Methods: Forty Wistar rats were randomly divided into two groups: the curcumin group, and the control group. The...

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Main Authors: Pedro Afonso Kono, Rivair Gonçalves Junior, Adriana Yuriko Koga, Melquesedeque dos Santos, Matheus Von Jelita Salina, Elder Dalazoana Filho, Alceu Toledo Junior, Leandro Cavalcante Lipinski, Marcos Ricardo da Silva Rodrigues, Eurico Cleto Ribeiro de Campos
Format: Article
Language:English
Published: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2025-07-01
Series:Acta Cirúrgica Brasileira
Subjects:
Disease Models, Animal
Curcumin
Tissue Adhesions
Inflammation
General Surgery
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502025000100227&lng=en&tlng=en
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Summary:ABSTRACT Purpose: To evaluate the effect of curcumin administered by gavage, on reducing intra-abdominal adhesions and attenuating the inflammatory process, assessed by a serum marker. Methods: Forty Wistar rats were randomly divided into two groups: the curcumin group, and the control group. The curcumin group received curcumin by gavage at the dose of 200 mg/kg over the seven days preceding and the seven days following surgery. In the control group, an isovolumetric administration of 0.9% saline solution was given by gavage. Both groups underwent a median laparotomy and left-sided colotomy. On the eighth postoperative day, the animals were euthanized for intracavitary adhesion analysis and left colon resection for histological examination. Intra-abdominal adhesions were classified from grade 0 to 4 based on increases in number, intensity, and ease of lysis. Results: Curcumin administration did not significantly reduce the severity of intra-abdominal adhesions (p = 0.7143) nor the severity of colonic inflammatory infiltration. However, a significant reduction in C-reactive protein levels was observed preoperatively in the curcumin group (p 0.05). Conclusion: While curcumin was not able to reduce the severity of intra-abdominal adhesions, it demonstrated the ability to attenuate the inflammatory process associated with the surgical procedure.
ISSN:1678-2674

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