E3 ubiquitin ligase RNF128 negatively regulates the IL-3/STAT5 signaling pathway by facilitating K27-linked polyubiquitination of IL-3Rα

E3 ubiquitin ligase RNF128 negatively regulates the IL-3/STAT5 signaling pathway by facilitating K27-linked polyubiquitination of IL-3Rα

Abstract IL-3/STAT5 signaling pathway is crucial for the development and activation of immune cells, contributing to the cellular response to infections and inflammatory stimuli. Dysregulation of the IL-3/STAT5 signaling have been associated with inflammatory and autoimmune diseases characterized by...

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Bibliographic Details
Main Authors: Jingge Yu, Jianguo Li, Ao Shen, Zhiping Liu, Tian-Sheng He
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Cell Communication and Signaling
Subjects:
Inflammation
IL-3
RNF128
Ubiquitination
Lysosomal degradation
Online Access:https://doi.org/10.1186/s12964-024-01636-4
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https://doi.org/10.1186/s12964-024-01636-4

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