Formulation Design and Development of a Unani Transdermal Patch for Antiemetic Therapy and Its Pharmaceutical Evaluation
The Transdermal Drug Delivery System (TDDS) is one of the novel routes for systemic delivery of drugs through intact skin. A transdermal patch (TP) is a medicated patch that is placed on skin for delivery of medication through skin into the blood stream. The aim of present study was to formulate and...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2016/7602347 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849407127104258048 |
|---|---|
| author | Mohd Nauman Saleem Mohammad Idris |
| author_facet | Mohd Nauman Saleem Mohammad Idris |
| author_sort | Mohd Nauman Saleem |
| collection | DOAJ |
| description | The Transdermal Drug Delivery System (TDDS) is one of the novel routes for systemic delivery of drugs through intact skin. A transdermal patch (TP) is a medicated patch that is placed on skin for delivery of medication through skin into the blood stream. The aim of present study was to formulate and evaluate a Unani transdermal patch that could be used for antiemetic therapy. The incorporation of Unani ingredients, namely, Khardal (Brassica nigra), Zanjabeel (Zingiber officinale), Podina (Mentha arvensis), and Sirka (Vinegar) were envisaged. The TP was prepared by solvent evaporation technique and was evaluated for organoleptic characteristics and other physicochemical properties, such as thickness, weight uniformity, folding endurance, moisture content, drug content, and tolerability and acceptability of patch. The in vitro permeation study of the patch was carried out through Franz diffusion cell using egg shell membrane as barrier membrane. Phosphate buffer pH 7.4 was used as dissolution medium and the temperature was maintained at 37 ± 1°C. The in vitro permeation study of the prepared TP indicated a time dependent increase in drug release throughout the study. The percentage of cumulative drug release was found to be 77.38% in 24 hours. The study shows a new approach to work in Unani pharmaceutics. |
| format | Article |
| id | doaj-art-4666edb2722d490fae986c22bbfc9db3 |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-4666edb2722d490fae986c22bbfc9db32025-08-20T03:36:11ZengWileyScientifica2090-908X2016-01-01201610.1155/2016/76023477602347Formulation Design and Development of a Unani Transdermal Patch for Antiemetic Therapy and Its Pharmaceutical EvaluationMohd Nauman Saleem0Mohammad Idris1Post Graduate Department of Ilm-us-Saidla, Ayurvedic & Unani Tibbia College, Karol Bagh, New Delhi 110005, IndiaDepartments of Ilm-us-Saidla & Advia, Ayurvedic & Unani Tibbia College, Karol Bagh, New Delhi 110005, IndiaThe Transdermal Drug Delivery System (TDDS) is one of the novel routes for systemic delivery of drugs through intact skin. A transdermal patch (TP) is a medicated patch that is placed on skin for delivery of medication through skin into the blood stream. The aim of present study was to formulate and evaluate a Unani transdermal patch that could be used for antiemetic therapy. The incorporation of Unani ingredients, namely, Khardal (Brassica nigra), Zanjabeel (Zingiber officinale), Podina (Mentha arvensis), and Sirka (Vinegar) were envisaged. The TP was prepared by solvent evaporation technique and was evaluated for organoleptic characteristics and other physicochemical properties, such as thickness, weight uniformity, folding endurance, moisture content, drug content, and tolerability and acceptability of patch. The in vitro permeation study of the patch was carried out through Franz diffusion cell using egg shell membrane as barrier membrane. Phosphate buffer pH 7.4 was used as dissolution medium and the temperature was maintained at 37 ± 1°C. The in vitro permeation study of the prepared TP indicated a time dependent increase in drug release throughout the study. The percentage of cumulative drug release was found to be 77.38% in 24 hours. The study shows a new approach to work in Unani pharmaceutics.http://dx.doi.org/10.1155/2016/7602347 |
| spellingShingle | Mohd Nauman Saleem Mohammad Idris Formulation Design and Development of a Unani Transdermal Patch for Antiemetic Therapy and Its Pharmaceutical Evaluation Scientifica |
| title | Formulation Design and Development of a Unani Transdermal Patch for Antiemetic Therapy and Its Pharmaceutical Evaluation |
| title_full | Formulation Design and Development of a Unani Transdermal Patch for Antiemetic Therapy and Its Pharmaceutical Evaluation |
| title_fullStr | Formulation Design and Development of a Unani Transdermal Patch for Antiemetic Therapy and Its Pharmaceutical Evaluation |
| title_full_unstemmed | Formulation Design and Development of a Unani Transdermal Patch for Antiemetic Therapy and Its Pharmaceutical Evaluation |
| title_short | Formulation Design and Development of a Unani Transdermal Patch for Antiemetic Therapy and Its Pharmaceutical Evaluation |
| title_sort | formulation design and development of a unani transdermal patch for antiemetic therapy and its pharmaceutical evaluation |
| url | http://dx.doi.org/10.1155/2016/7602347 |
| work_keys_str_mv | AT mohdnaumansaleem formulationdesignanddevelopmentofaunanitransdermalpatchforantiemetictherapyanditspharmaceuticalevaluation AT mohammadidris formulationdesignanddevelopmentofaunanitransdermalpatchforantiemetictherapyanditspharmaceuticalevaluation |