The emerging role of microbiota derived SCFAs in neurodegenerative disorders
The microbiota-gut-brain axis (MGBA), the bidirectional communication network between the gastrointestinal tract and the central nervous system, plays a significant role in the pathophysiology of neurodegenerative disorders. Emerging research highlights how gut microbiota dysbiosis, or an imbalance...
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Elsevier
2025-07-01
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| Series: | Brain, Behavior, & Immunity - Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354625000705 |
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| author | Samuel Wachamo Alban Gaultier |
| author_facet | Samuel Wachamo Alban Gaultier |
| author_sort | Samuel Wachamo |
| collection | DOAJ |
| description | The microbiota-gut-brain axis (MGBA), the bidirectional communication network between the gastrointestinal tract and the central nervous system, plays a significant role in the pathophysiology of neurodegenerative disorders. Emerging research highlights how gut microbiota dysbiosis, or an imbalance in the microbial community, is linked to the etiology and pathology of these conditions. Microbiota dysbiosis leads to changes in the production of microbial metabolites, such as short-chain fatty acids (SCFAs), which can cross the intestinal barrier and influence the brain either directly or indirectly. Understanding the mechanisms by which dysfunction in the MGBA contributes to neurodegeneration opens potential avenues for novel therapeutic strategies, including microbiota-targeted interventions. This review introduces the MGBA, discusses the role of SCFAs within the MGBA in the context of neurodegenerative disorders, and suggests future research directions. |
| format | Article |
| id | doaj-art-4661ac09032d41e2a2d37a3735249dd8 |
| institution | DOAJ |
| issn | 2666-3546 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj-art-4661ac09032d41e2a2d37a3735249dd82025-08-20T03:21:15ZengElsevierBrain, Behavior, & Immunity - Health2666-35462025-07-014610101210.1016/j.bbih.2025.101012The emerging role of microbiota derived SCFAs in neurodegenerative disordersSamuel Wachamo0Alban Gaultier1Department of Neuroscience, University of Virginia, Charlottesville, VA, USA; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA; Center for Brain Immunology and Glia, University of Virginia, Charlottesville, VA, USA; Medical Scientist Training Program, School of Medicine, University of Virginia, Charlottesville, VA, USA; Corresponding author. Department of Neuroscience, University of Virginia, Charlottesville, VA, USA.Department of Neuroscience, University of Virginia, Charlottesville, VA, USA; Center for Brain Immunology and Glia, University of Virginia, Charlottesville, VA, USAThe microbiota-gut-brain axis (MGBA), the bidirectional communication network between the gastrointestinal tract and the central nervous system, plays a significant role in the pathophysiology of neurodegenerative disorders. Emerging research highlights how gut microbiota dysbiosis, or an imbalance in the microbial community, is linked to the etiology and pathology of these conditions. Microbiota dysbiosis leads to changes in the production of microbial metabolites, such as short-chain fatty acids (SCFAs), which can cross the intestinal barrier and influence the brain either directly or indirectly. Understanding the mechanisms by which dysfunction in the MGBA contributes to neurodegeneration opens potential avenues for novel therapeutic strategies, including microbiota-targeted interventions. This review introduces the MGBA, discusses the role of SCFAs within the MGBA in the context of neurodegenerative disorders, and suggests future research directions.http://www.sciencedirect.com/science/article/pii/S2666354625000705MicrobiotaMicrobiota-gut-brain axis (MGBA)DysbiosisShort-chain fatty acids (SCFAs)Neurodegenerative disorders |
| spellingShingle | Samuel Wachamo Alban Gaultier The emerging role of microbiota derived SCFAs in neurodegenerative disorders Brain, Behavior, & Immunity - Health Microbiota Microbiota-gut-brain axis (MGBA) Dysbiosis Short-chain fatty acids (SCFAs) Neurodegenerative disorders |
| title | The emerging role of microbiota derived SCFAs in neurodegenerative disorders |
| title_full | The emerging role of microbiota derived SCFAs in neurodegenerative disorders |
| title_fullStr | The emerging role of microbiota derived SCFAs in neurodegenerative disorders |
| title_full_unstemmed | The emerging role of microbiota derived SCFAs in neurodegenerative disorders |
| title_short | The emerging role of microbiota derived SCFAs in neurodegenerative disorders |
| title_sort | emerging role of microbiota derived scfas in neurodegenerative disorders |
| topic | Microbiota Microbiota-gut-brain axis (MGBA) Dysbiosis Short-chain fatty acids (SCFAs) Neurodegenerative disorders |
| url | http://www.sciencedirect.com/science/article/pii/S2666354625000705 |
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