Albumin-to-Fibrinogen Ratio Independently Predicts 28-Day Mortality in Patients with Peritonitis-Induced Sepsis
Background. This study is aimed at investigating whether albumin-to-fibrinogen ratio (AFR) could independently predict the prognosis in patients with peritonitis-induced sepsis. Methods. A total of 246 eligible patients who were scheduled to undergo surgical treatment for peritonitis-induced sepsis...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/7280708 |
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| author | Huiyu Tai Zhiyun Zhu Haifeng Mei Wenbin Sun Wei Zhang |
| author_facet | Huiyu Tai Zhiyun Zhu Haifeng Mei Wenbin Sun Wei Zhang |
| author_sort | Huiyu Tai |
| collection | DOAJ |
| description | Background. This study is aimed at investigating whether albumin-to-fibrinogen ratio (AFR) could independently predict the prognosis in patients with peritonitis-induced sepsis. Methods. A total of 246 eligible patients who were scheduled to undergo surgical treatment for peritonitis-induced sepsis were enrolled in this study. The primary observational endpoint was 28-day hospital mortality. Cox proportional hazards regression analysis with the Wald test was performed to identify prognostic factors for 28-day mortality in septic patients. Receiver operating characteristic (ROC) and Kaplan-Meier curve analyses were carried out to evaluate the association of baseline AFR and prognosis in septic patients. Results. Of all the cohort study participants, there were 59 nonsurvivors with a 28-day mortality of 24.0% (59/246). Baseline AFR (hazard ratio (HR): 0.67, 95% confidence interval (CI): 0.42–0.93, P=0.018) and the presence of septic shock (HR: 2.43, 95% CI: 1.42–3.91, P=0.021) were two independent prognostic factors for 28-day mortality in patients with peritonitis-induced sepsis by multivariate Cox analysis. Baseline AFR was a significant predictor for 28-day mortality with an area under the curve (AUC) of 0.751, a cut-off value of 8.85, a sensitivity of 66.10%, and a specificity of 70.05%, respectively (95% CI: 0.688–0.813, P<0.001). A low baseline AFR level (≤8.85) was significantly associated with a lower overall survival rate in septic patients by Kaplan-Meier curve analysis with log-rank test (P=0.004). Conclusions. This study indicates that AFR independently predicts 28-day mortality in patients with peritonitis-induced sepsis. |
| format | Article |
| id | doaj-art-465f7cf4565641a498292aa06634e06e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-465f7cf4565641a498292aa06634e06e2025-02-03T06:05:18ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/72807087280708Albumin-to-Fibrinogen Ratio Independently Predicts 28-Day Mortality in Patients with Peritonitis-Induced SepsisHuiyu Tai0Zhiyun Zhu1Haifeng Mei2Wenbin Sun3Wei Zhang4Department of Intensive Care Unit, Taizhou People’s Hospital, Medical School of Nantong University, ChinaDepartment of Intensive Care Unit, Taizhou People’s Hospital, Medical School of Nantong University, ChinaDepartment of Intensive Care Unit, Taizhou People’s Hospital, Medical School of Nantong University, ChinaDepartment of Intensive Care Unit, Taizhou People’s Hospital, Medical School of Nantong University, ChinaDepartment of Infectious Disease, Taizhou People’s Hospital, Medical School of Nantong University, ChinaBackground. This study is aimed at investigating whether albumin-to-fibrinogen ratio (AFR) could independently predict the prognosis in patients with peritonitis-induced sepsis. Methods. A total of 246 eligible patients who were scheduled to undergo surgical treatment for peritonitis-induced sepsis were enrolled in this study. The primary observational endpoint was 28-day hospital mortality. Cox proportional hazards regression analysis with the Wald test was performed to identify prognostic factors for 28-day mortality in septic patients. Receiver operating characteristic (ROC) and Kaplan-Meier curve analyses were carried out to evaluate the association of baseline AFR and prognosis in septic patients. Results. Of all the cohort study participants, there were 59 nonsurvivors with a 28-day mortality of 24.0% (59/246). Baseline AFR (hazard ratio (HR): 0.67, 95% confidence interval (CI): 0.42–0.93, P=0.018) and the presence of septic shock (HR: 2.43, 95% CI: 1.42–3.91, P=0.021) were two independent prognostic factors for 28-day mortality in patients with peritonitis-induced sepsis by multivariate Cox analysis. Baseline AFR was a significant predictor for 28-day mortality with an area under the curve (AUC) of 0.751, a cut-off value of 8.85, a sensitivity of 66.10%, and a specificity of 70.05%, respectively (95% CI: 0.688–0.813, P<0.001). A low baseline AFR level (≤8.85) was significantly associated with a lower overall survival rate in septic patients by Kaplan-Meier curve analysis with log-rank test (P=0.004). Conclusions. This study indicates that AFR independently predicts 28-day mortality in patients with peritonitis-induced sepsis.http://dx.doi.org/10.1155/2020/7280708 |
| spellingShingle | Huiyu Tai Zhiyun Zhu Haifeng Mei Wenbin Sun Wei Zhang Albumin-to-Fibrinogen Ratio Independently Predicts 28-Day Mortality in Patients with Peritonitis-Induced Sepsis Mediators of Inflammation |
| title | Albumin-to-Fibrinogen Ratio Independently Predicts 28-Day Mortality in Patients with Peritonitis-Induced Sepsis |
| title_full | Albumin-to-Fibrinogen Ratio Independently Predicts 28-Day Mortality in Patients with Peritonitis-Induced Sepsis |
| title_fullStr | Albumin-to-Fibrinogen Ratio Independently Predicts 28-Day Mortality in Patients with Peritonitis-Induced Sepsis |
| title_full_unstemmed | Albumin-to-Fibrinogen Ratio Independently Predicts 28-Day Mortality in Patients with Peritonitis-Induced Sepsis |
| title_short | Albumin-to-Fibrinogen Ratio Independently Predicts 28-Day Mortality in Patients with Peritonitis-Induced Sepsis |
| title_sort | albumin to fibrinogen ratio independently predicts 28 day mortality in patients with peritonitis induced sepsis |
| url | http://dx.doi.org/10.1155/2020/7280708 |
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