Clinical and Prognostic Value of VHL in Korean Patients with Rectal Cancer
<i>Background and Objectives</i>: Von Hippel–Lindau (VHL) disease is caused by mutations in the VHL gene and can develop various cancers. Hypoxia-inducible factors 1 and 2 alphas, regulated by the VHL gene, can increase the levels of vascular endothelial growth factor, thereby activating...
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MDPI AG
2025-02-01
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| Online Access: | https://www.mdpi.com/1648-9144/61/2/306 |
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| author | Sang-Won Moon Jun-Chae Lee Jae-Ho Lee Tae-Young Kim Jong Ho Park |
| author_facet | Sang-Won Moon Jun-Chae Lee Jae-Ho Lee Tae-Young Kim Jong Ho Park |
| author_sort | Sang-Won Moon |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Von Hippel–Lindau (VHL) disease is caused by mutations in the VHL gene and can develop various cancers. Hypoxia-inducible factors 1 and 2 alphas, regulated by the VHL gene, can increase the levels of vascular endothelial growth factor, thereby activating cancer progression. Here, we demonstrated clinical and prognostic values of VHL expression in rectal cancer (RC). <i>Materials and Methods</i>: Von Hippel–Lindau mRNA expression was examined in 60 patients with RC. Furthermore, we evaluated survival to determine the prognostic significance of VHL mRNA expression levels in RC using the Cancer Genome Atlas (TCGA) data. <i>Results</i>: Lower VHL expression was correlated with the recurrence (<i>p</i> = 0.058) and lymphatic invasion (<i>p</i> = 0.078), although it was not statistically significant. In TCGA data, VHL expression level was correlated with the M stage (<i>p</i> = 0.044); however, it had a possible association with lymphatic invasion (<i>p</i> = 0.068) and N stage (<i>p</i> = 0.104). Survival analysis showed that lower VHL gene expression predicted poorer survival in both patients with RC and TCGA data. <i>Conclusions</i>: This study identified a significant correlation between VHL gene expression and RC for the first time using patient tissues and TCGA data, suggesting that the VHL gene expression level could be a potential biomarker or candidate for the treatment of RC. Further studies are required to identify the molecular pathogenesis and clinical characteristics of VHL disease in RC. |
| format | Article |
| id | doaj-art-465f1388f5944ec89cb0803a6c6ec2bf |
| institution | DOAJ |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj-art-465f1388f5944ec89cb0803a6c6ec2bf2025-08-20T02:44:46ZengMDPI AGMedicina1010-660X1648-91442025-02-0161230610.3390/medicina61020306Clinical and Prognostic Value of VHL in Korean Patients with Rectal CancerSang-Won Moon0Jun-Chae Lee1Jae-Ho Lee2Tae-Young Kim3Jong Ho Park4Medical Course, School of Medicine, Keimyung University, Daegu 42601, Republic of KoreaMedical Course, School of Medicine, Keimyung University, Daegu 42601, Republic of KoreaDepartment of Anatomy, School of Medicine & Institute for Medical Science, Keimyung University, Daegu 42601, Republic of KoreaDepartment of Anatomy, School of Medicine & Institute for Medical Science, Keimyung University, Daegu 42601, Republic of KoreaDepartment of Anatomy, School of Medicine & Institute for Medical Science, Keimyung University, Daegu 42601, Republic of Korea<i>Background and Objectives</i>: Von Hippel–Lindau (VHL) disease is caused by mutations in the VHL gene and can develop various cancers. Hypoxia-inducible factors 1 and 2 alphas, regulated by the VHL gene, can increase the levels of vascular endothelial growth factor, thereby activating cancer progression. Here, we demonstrated clinical and prognostic values of VHL expression in rectal cancer (RC). <i>Materials and Methods</i>: Von Hippel–Lindau mRNA expression was examined in 60 patients with RC. Furthermore, we evaluated survival to determine the prognostic significance of VHL mRNA expression levels in RC using the Cancer Genome Atlas (TCGA) data. <i>Results</i>: Lower VHL expression was correlated with the recurrence (<i>p</i> = 0.058) and lymphatic invasion (<i>p</i> = 0.078), although it was not statistically significant. In TCGA data, VHL expression level was correlated with the M stage (<i>p</i> = 0.044); however, it had a possible association with lymphatic invasion (<i>p</i> = 0.068) and N stage (<i>p</i> = 0.104). Survival analysis showed that lower VHL gene expression predicted poorer survival in both patients with RC and TCGA data. <i>Conclusions</i>: This study identified a significant correlation between VHL gene expression and RC for the first time using patient tissues and TCGA data, suggesting that the VHL gene expression level could be a potential biomarker or candidate for the treatment of RC. Further studies are required to identify the molecular pathogenesis and clinical characteristics of VHL disease in RC.https://www.mdpi.com/1648-9144/61/2/306VHLTCGArectal cancer |
| spellingShingle | Sang-Won Moon Jun-Chae Lee Jae-Ho Lee Tae-Young Kim Jong Ho Park Clinical and Prognostic Value of VHL in Korean Patients with Rectal Cancer Medicina VHL TCGA rectal cancer |
| title | Clinical and Prognostic Value of VHL in Korean Patients with Rectal Cancer |
| title_full | Clinical and Prognostic Value of VHL in Korean Patients with Rectal Cancer |
| title_fullStr | Clinical and Prognostic Value of VHL in Korean Patients with Rectal Cancer |
| title_full_unstemmed | Clinical and Prognostic Value of VHL in Korean Patients with Rectal Cancer |
| title_short | Clinical and Prognostic Value of VHL in Korean Patients with Rectal Cancer |
| title_sort | clinical and prognostic value of vhl in korean patients with rectal cancer |
| topic | VHL TCGA rectal cancer |
| url | https://www.mdpi.com/1648-9144/61/2/306 |
| work_keys_str_mv | AT sangwonmoon clinicalandprognosticvalueofvhlinkoreanpatientswithrectalcancer AT junchaelee clinicalandprognosticvalueofvhlinkoreanpatientswithrectalcancer AT jaeholee clinicalandprognosticvalueofvhlinkoreanpatientswithrectalcancer AT taeyoungkim clinicalandprognosticvalueofvhlinkoreanpatientswithrectalcancer AT jonghopark clinicalandprognosticvalueofvhlinkoreanpatientswithrectalcancer |