HNF4α contributes to hepatic CAR dysfunction in polymicrobial sepsis

HNF4α contributes to hepatic CAR dysfunction in polymicrobial sepsis

The constitutive androstane receptor (CAR), encoded by the Nr1i3 gene, is a nuclear receptor mainly expressed in the liver, where it regulates (xenobiotic) drug and bile acid metabolism, bilirubin clearance and energy homeostasis. CAR has emerged as a promising therapeutic target for diabetes, fatty...

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Main Authors: Céline Van Dender, Steven Timmermans, Maxime Roes, Madeleine Hellemans, Elise Moens, Louise Nuyttens, Maarten Claes, Bart Roman, Karolien De Bosscher, Jolien Vandewalle, Claude Libert
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
HNF4α
CAR dysfunction
liver
sepsis
acute phase response
metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1625104/full
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