Unraveling relationship between the genetic polymorphism CYP2A13 and nicotine metabolism of male smokers in Medan, Indonesia

Unraveling relationship between the genetic polymorphism CYP2A13 and nicotine metabolism of male smokers in Medan, Indonesia

Abstract Background Nicotine metabolism significantly influences the levels of harmful nicotine metabolites in smokers. CYP2A13, a key enzyme in nicotine and xenobiotic metabolism, is implicated in tobacco smoke-related lung cancer. Aim This study investigated the association between CYP2A13 genetic...

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Bibliographic Details
Main Authors: Noni Novisari Soeroso, Rozaimah Zain-Hamid, Syamsul Bihar, Chaliza Soliha, Fannie Rizki Ananda, Aida
Format: Article
Language:English
Published: SpringerOpen 2025-02-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
CYP2A13 polymorphism
Male smokers
Nicotine metabolism
Nicotine metabolite ratio
Indonesia
Online Access:https://doi.org/10.1186/s43042-025-00653-3
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