Uses and Abuses of Intestinal Permeability Measurements
Intestinal permeability has been assessed with three different classes of permeability probes, viz various sugar mixtures, 51Cr-EDTA and poly(ethylene glycol). The former two methods are having increasing clinical applications in the screening and assessment of small intestinal damage and 51Cr-EDTA...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1988-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1988/867416 |
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| Summary: | Intestinal permeability has been assessed with three different classes
of permeability probes, viz various sugar mixtures, 51Cr-EDTA and poly(ethylene
glycol). The former two methods are having increasing clinical applications in the
screening and assessment of small intestinal damage and 51Cr-EDTA is now the preferred
probe for routine clinical use. Poly(ethylene glycol)s have numerous disadvantages
and are not recommended. Probes may be used both in vitro and in vivo
and have been applied to a wide variety of clinical problems. In particular, NSAID induced
enteropathy, a major complication of the chronic administration of these
widely-used drugs, was recognized for the first time with 51Cr-EDTA permeability
measurements. The cytoprotective role of various prostanoids was also clearly demonstrated
using 51Cr-EDTA. It is anticipated that measurement of intestinal permeability
will play an increasing role in clinical and research investigation and in the
monitoring of intestinal disease. |
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| ISSN: | 0835-7900 |