A novel lidocaine-chitosan-barium titanate microemulsion gel for prolonged local anesthesia: An in vitro study
This study investigated the efficacy of a novel lidocaine-chitosan-barium titanate microemulsion gel for prolonged local anesthesia. The lidocaine microemulsion comprised 5% (w/w) lidocaine, linoleic acid (LA), chitosan, barium titanate (BaTiO3), Cremophor RH40, Tween 20, and water. Dynamic light sc...
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University of Belgrade, University of Novi Sad
2024-01-01
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| Series: | Archives of Biological Sciences |
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| Online Access: | https://doiserbia.nb.rs/img/doi/0354-4664/2024/0354-46642400024Q.pdf |
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| author | Qiao Xiaoru Li Ling |
| author_facet | Qiao Xiaoru Li Ling |
| author_sort | Qiao Xiaoru |
| collection | DOAJ |
| description | This study investigated the efficacy of a novel lidocaine-chitosan-barium titanate microemulsion gel for prolonged local anesthesia. The lidocaine microemulsion comprised 5% (w/w) lidocaine, linoleic acid (LA), chitosan, barium titanate (BaTiO3), Cremophor RH40, Tween 20, and water. Dynamic light scattering was utilized to analyze the particle size of the prepared microemulsions. The optimized microemulsion was transformed into a microemulsion gel to extend the duration of the microemulsion when administered to specific areas. Virgin oil was used as an auxiliary oil to increase the microemulsion area, allowing for a reduced amount of surfactant. In vitro analysis was conducted to evaluate the release of lidocaine from the microemulsion. The lidocaine/chitosan/BaTiO3 ranged in size from 7-30 nm, displaying a narrow particle size distribution. The polydispersity index (PDI) value was 0.989. Lidocaine/chitosan with BaTiO3 nanoparticles as a carrier achieved over 84% drug release, whereas the lidocaine/chitosan without the BaTiO3 nanoparticles only reached 52% cumulative release. At the concentrations used, the lidocaine-loaded chitosan and lidocaine-loaded chitosan with BaTiO3 showed a moderate effect on cellular viability. In conclusion, a new formulation of lidocaine microemulsions containing chitosan and BaTiO3 was developed and utilized to deliver lidocaine through the skin to achieve topical anesthesia. |
| format | Article |
| id | doaj-art-464adcd42d60447395347351b719da1b |
| institution | Kabale University |
| issn | 0354-4664 1821-4339 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj-art-464adcd42d60447395347351b719da1b2025-01-30T06:38:33ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46641821-43392024-01-0176332533310.2298/ABS240707024Q0354-46642400024QA novel lidocaine-chitosan-barium titanate microemulsion gel for prolonged local anesthesia: An in vitro studyQiao Xiaoru0https://orcid.org/0009-0003-0458-5632Li Ling1https://orcid.org/0009-0003-1201-0695Department of Anesthesiology, Ankang Central Hospital, Ankang City, Shaanxi Province, ChinaDepartment of Anesthesiology, Ankang Central Hospital, Ankang City, Shaanxi Province, ChinaThis study investigated the efficacy of a novel lidocaine-chitosan-barium titanate microemulsion gel for prolonged local anesthesia. The lidocaine microemulsion comprised 5% (w/w) lidocaine, linoleic acid (LA), chitosan, barium titanate (BaTiO3), Cremophor RH40, Tween 20, and water. Dynamic light scattering was utilized to analyze the particle size of the prepared microemulsions. The optimized microemulsion was transformed into a microemulsion gel to extend the duration of the microemulsion when administered to specific areas. Virgin oil was used as an auxiliary oil to increase the microemulsion area, allowing for a reduced amount of surfactant. In vitro analysis was conducted to evaluate the release of lidocaine from the microemulsion. The lidocaine/chitosan/BaTiO3 ranged in size from 7-30 nm, displaying a narrow particle size distribution. The polydispersity index (PDI) value was 0.989. Lidocaine/chitosan with BaTiO3 nanoparticles as a carrier achieved over 84% drug release, whereas the lidocaine/chitosan without the BaTiO3 nanoparticles only reached 52% cumulative release. At the concentrations used, the lidocaine-loaded chitosan and lidocaine-loaded chitosan with BaTiO3 showed a moderate effect on cellular viability. In conclusion, a new formulation of lidocaine microemulsions containing chitosan and BaTiO3 was developed and utilized to deliver lidocaine through the skin to achieve topical anesthesia.https://doiserbia.nb.rs/img/doi/0354-4664/2024/0354-46642400024Q.pdflidocainechitosanbarium titanate (batio3)microemulsionlocal anesthesia |
| spellingShingle | Qiao Xiaoru Li Ling A novel lidocaine-chitosan-barium titanate microemulsion gel for prolonged local anesthesia: An in vitro study Archives of Biological Sciences lidocaine chitosan barium titanate (batio3) microemulsion local anesthesia |
| title | A novel lidocaine-chitosan-barium titanate microemulsion gel for prolonged local anesthesia: An in vitro study |
| title_full | A novel lidocaine-chitosan-barium titanate microemulsion gel for prolonged local anesthesia: An in vitro study |
| title_fullStr | A novel lidocaine-chitosan-barium titanate microemulsion gel for prolonged local anesthesia: An in vitro study |
| title_full_unstemmed | A novel lidocaine-chitosan-barium titanate microemulsion gel for prolonged local anesthesia: An in vitro study |
| title_short | A novel lidocaine-chitosan-barium titanate microemulsion gel for prolonged local anesthesia: An in vitro study |
| title_sort | novel lidocaine chitosan barium titanate microemulsion gel for prolonged local anesthesia an in vitro study |
| topic | lidocaine chitosan barium titanate (batio3) microemulsion local anesthesia |
| url | https://doiserbia.nb.rs/img/doi/0354-4664/2024/0354-46642400024Q.pdf |
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