gamma-H2AX: A potential biomarker in breast cancer
Histone H2AX undergoes phosphorylation as an answer to DNA double-strand breaks, which in turn are part of the oncogenic procedure. The detection of gamma-H2AX can potentially serve as a biomarker for transformation of normal tissue to premalignant and consequently to malignant tissues. The aim of t...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-09-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428319878536 |
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| _version_ | 1850051194803716096 |
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| author | Palla Viktoria Varvara Georgios Karaolanis Christos Valavanis Gabriela Stanc Olympia Tzaida Helen Trihia Paul Patapis Dimitrios Dimitroulis Despoina Perrea |
| author_facet | Palla Viktoria Varvara Georgios Karaolanis Christos Valavanis Gabriela Stanc Olympia Tzaida Helen Trihia Paul Patapis Dimitrios Dimitroulis Despoina Perrea |
| author_sort | Palla Viktoria Varvara |
| collection | DOAJ |
| description | Histone H2AX undergoes phosphorylation as an answer to DNA double-strand breaks, which in turn are part of the oncogenic procedure. The detection of gamma-H2AX can potentially serve as a biomarker for transformation of normal tissue to premalignant and consequently to malignant tissues. The aim of this study was to evaluate the clinical significance of gamma-H2AX expression in breast cancer. Gamma-H2AX expression in tissues from 110 breast cancer patients was analyzed by immunohistochemistry and correlated with clinicopathological variables. Greater tumor size, higher grade, and the number of affected lymph nodes are significantly associated with greater values of gamma-H2AX. In addition, gamma-H2AX differs significantly among patients’ International Federation of Gynecology and Obstetrics stage. Higher values of estrogen receptor and progesterone receptor are significantly associated with lower gamma-H2AX values. In conclusion, a positive association between gamma-H2AX expression and infaust histopathological parameters was observed. |
| format | Article |
| id | doaj-art-464aa27e1203410fbf8178b1ecbd095d |
| institution | DOAJ |
| issn | 1423-0380 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-464aa27e1203410fbf8178b1ecbd095d2025-08-20T02:53:13ZengSAGE PublishingTumor Biology1423-03802019-09-014110.1177/1010428319878536gamma-H2AX: A potential biomarker in breast cancerPalla Viktoria Varvara0Georgios Karaolanis1Christos Valavanis2Gabriela Stanc3Olympia Tzaida4Helen Trihia5Paul Patapis6Dimitrios Dimitroulis7Despoina Perrea8Department of Obstetrics and Gynecology, Diakonie-Klinikum Schwäbisch Hall, Schwäbisch Hall, Germany1st Department of Surgery, Vascular Unit, Laiko General Hospital, Medical School of Athens, Athens, GreeceDepartment of Pathology, Metaxa Cancer Hospital, Piraeus, GreeceDepartment of Pathology, Metaxa Cancer Hospital, Piraeus, GreeceDepartment of Pathology, Metaxa Cancer Hospital, Piraeus, GreeceDepartment of Pathology, Metaxa Cancer Hospital, Piraeus, Greece3rd Department of Surgery, Attikon General Hospital, University of Athens, Athens, Greece2nd Department of Surgery, Laiko Hospital, University of Athens, Athens, Greece2nd Department of Surgery, Laiko Hospital, University of Athens, Athens, GreeceHistone H2AX undergoes phosphorylation as an answer to DNA double-strand breaks, which in turn are part of the oncogenic procedure. The detection of gamma-H2AX can potentially serve as a biomarker for transformation of normal tissue to premalignant and consequently to malignant tissues. The aim of this study was to evaluate the clinical significance of gamma-H2AX expression in breast cancer. Gamma-H2AX expression in tissues from 110 breast cancer patients was analyzed by immunohistochemistry and correlated with clinicopathological variables. Greater tumor size, higher grade, and the number of affected lymph nodes are significantly associated with greater values of gamma-H2AX. In addition, gamma-H2AX differs significantly among patients’ International Federation of Gynecology and Obstetrics stage. Higher values of estrogen receptor and progesterone receptor are significantly associated with lower gamma-H2AX values. In conclusion, a positive association between gamma-H2AX expression and infaust histopathological parameters was observed.https://doi.org/10.1177/1010428319878536 |
| spellingShingle | Palla Viktoria Varvara Georgios Karaolanis Christos Valavanis Gabriela Stanc Olympia Tzaida Helen Trihia Paul Patapis Dimitrios Dimitroulis Despoina Perrea gamma-H2AX: A potential biomarker in breast cancer Tumor Biology |
| title | gamma-H2AX: A potential biomarker in breast cancer |
| title_full | gamma-H2AX: A potential biomarker in breast cancer |
| title_fullStr | gamma-H2AX: A potential biomarker in breast cancer |
| title_full_unstemmed | gamma-H2AX: A potential biomarker in breast cancer |
| title_short | gamma-H2AX: A potential biomarker in breast cancer |
| title_sort | gamma h2ax a potential biomarker in breast cancer |
| url | https://doi.org/10.1177/1010428319878536 |
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