Analysis of Morphologic and Functional Outcomes in Macular Edema due to Central Retinal Vein Occlusion Treated with Intravitreal Dexamethasone Implant
Purpose. To analyze anatomic and functional retinal changes and their correlation after intravitreal dexamethasone implant (DEX implant) in patients with central retinal vein occlusion- (CRVO-) related macular edema (ME) using optical coherence tomography and microperimetry. Methods. Fifteen treatme...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2018/5604632 |
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| author | Alfredo Niro Giancarlo Sborgia Alessandra Sborgia Luigi Sborgia Claudio Furino Nicola Recchimurzo Giovanni Alessio |
| author_facet | Alfredo Niro Giancarlo Sborgia Alessandra Sborgia Luigi Sborgia Claudio Furino Nicola Recchimurzo Giovanni Alessio |
| author_sort | Alfredo Niro |
| collection | DOAJ |
| description | Purpose. To analyze anatomic and functional retinal changes and their correlation after intravitreal dexamethasone implant (DEX implant) in patients with central retinal vein occlusion- (CRVO-) related macular edema (ME) using optical coherence tomography and microperimetry. Methods. Fifteen treatment-naïve patients with functional impairment due to CRVO-related ME were enrolled in this prospective interventional case series. Main outcomes were best-corrected visual acuity (BCVA), retinal sensitivity (RS), and central retinal thickness (CRT). Secondary outcomes were ellipsoid zone (EZ) status and fixation behaviour. All patients underwent DEX implant and were retreated according to predefined criteria. Data were prospectively recorded at baseline and at month 1, 3, 6, 9, and 12. Correlation between main outcomes was analyzed. Results. Fifteen eyes of 15 patients (9 men, 6 women; mean age 61.8 ± 10.9 years) were included. BCVA and CRT significantly improved at all follow-up visits, while RS significantly improved at 3, 6, 9, and 12 months. EZ status and fixation behaviour did not change significantly. Baseline CRT had a significant negative correlation with BCVA and RS at different follow-up visits (r=−0.52 to −0.63, p≤0.04; r=−0.52, p=0.04; resp.). At all time points, there was not a significant correlation between CRT and BCVA and RS, while RS and BCVA showed a significant correlation, increasing over time (r=−0.72 to −0.89; p<0.001). Conclusion. DEX implant led to a significant morphofunctional improvement. Baseline CRT is predictive of changes of functional outcomes whose correlation increases over time after treatment. |
| format | Article |
| id | doaj-art-464148ae18464f33ad93b01e0785a6be |
| institution | OA Journals |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-464148ae18464f33ad93b01e0785a6be2025-08-20T02:37:48ZengWileyJournal of Ophthalmology2090-004X2090-00582018-01-01201810.1155/2018/56046325604632Analysis of Morphologic and Functional Outcomes in Macular Edema due to Central Retinal Vein Occlusion Treated with Intravitreal Dexamethasone ImplantAlfredo Niro0Giancarlo Sborgia1Alessandra Sborgia2Luigi Sborgia3Claudio Furino4Nicola Recchimurzo5Giovanni Alessio6Department of Medical Science, Neuroscience and Sense Organs, Eye Clinic, University of Bari “A. Moro”, Bari, ItalyDepartment of Medical Science, Neuroscience and Sense Organs, Eye Clinic, University of Bari “A. Moro”, Bari, ItalyDepartment of Medical Science, Neuroscience and Sense Organs, Eye Clinic, University of Bari “A. Moro”, Bari, ItalyDepartment of Medical Science, Neuroscience and Sense Organs, Eye Clinic, University of Bari “A. Moro”, Bari, ItalyDepartment of Medical Science, Neuroscience and Sense Organs, Eye Clinic, University of Bari “A. Moro”, Bari, ItalyDepartment of Medical Science, Neuroscience and Sense Organs, Eye Clinic, University of Bari “A. Moro”, Bari, ItalyDepartment of Medical Science, Neuroscience and Sense Organs, Eye Clinic, University of Bari “A. Moro”, Bari, ItalyPurpose. To analyze anatomic and functional retinal changes and their correlation after intravitreal dexamethasone implant (DEX implant) in patients with central retinal vein occlusion- (CRVO-) related macular edema (ME) using optical coherence tomography and microperimetry. Methods. Fifteen treatment-naïve patients with functional impairment due to CRVO-related ME were enrolled in this prospective interventional case series. Main outcomes were best-corrected visual acuity (BCVA), retinal sensitivity (RS), and central retinal thickness (CRT). Secondary outcomes were ellipsoid zone (EZ) status and fixation behaviour. All patients underwent DEX implant and were retreated according to predefined criteria. Data were prospectively recorded at baseline and at month 1, 3, 6, 9, and 12. Correlation between main outcomes was analyzed. Results. Fifteen eyes of 15 patients (9 men, 6 women; mean age 61.8 ± 10.9 years) were included. BCVA and CRT significantly improved at all follow-up visits, while RS significantly improved at 3, 6, 9, and 12 months. EZ status and fixation behaviour did not change significantly. Baseline CRT had a significant negative correlation with BCVA and RS at different follow-up visits (r=−0.52 to −0.63, p≤0.04; r=−0.52, p=0.04; resp.). At all time points, there was not a significant correlation between CRT and BCVA and RS, while RS and BCVA showed a significant correlation, increasing over time (r=−0.72 to −0.89; p<0.001). Conclusion. DEX implant led to a significant morphofunctional improvement. Baseline CRT is predictive of changes of functional outcomes whose correlation increases over time after treatment.http://dx.doi.org/10.1155/2018/5604632 |
| spellingShingle | Alfredo Niro Giancarlo Sborgia Alessandra Sborgia Luigi Sborgia Claudio Furino Nicola Recchimurzo Giovanni Alessio Analysis of Morphologic and Functional Outcomes in Macular Edema due to Central Retinal Vein Occlusion Treated with Intravitreal Dexamethasone Implant Journal of Ophthalmology |
| title | Analysis of Morphologic and Functional Outcomes in Macular Edema due to Central Retinal Vein Occlusion Treated with Intravitreal Dexamethasone Implant |
| title_full | Analysis of Morphologic and Functional Outcomes in Macular Edema due to Central Retinal Vein Occlusion Treated with Intravitreal Dexamethasone Implant |
| title_fullStr | Analysis of Morphologic and Functional Outcomes in Macular Edema due to Central Retinal Vein Occlusion Treated with Intravitreal Dexamethasone Implant |
| title_full_unstemmed | Analysis of Morphologic and Functional Outcomes in Macular Edema due to Central Retinal Vein Occlusion Treated with Intravitreal Dexamethasone Implant |
| title_short | Analysis of Morphologic and Functional Outcomes in Macular Edema due to Central Retinal Vein Occlusion Treated with Intravitreal Dexamethasone Implant |
| title_sort | analysis of morphologic and functional outcomes in macular edema due to central retinal vein occlusion treated with intravitreal dexamethasone implant |
| url | http://dx.doi.org/10.1155/2018/5604632 |
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