Advances in the application of extracellular vesicles in precise diagnosis of pancreatic cancer
Abstract Pancreatic cancer is a highly malignant tumor with poor prognosis, emphasizing the need for accurate early diagnosis. EVs, as mediators of intercellular communication, carry DNA, RNA, and proteins that show differential but not tumor-specific expression patterns in pancreatic cancer. Studie...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-06-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-025-02739-5 |
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| Summary: | Abstract Pancreatic cancer is a highly malignant tumor with poor prognosis, emphasizing the need for accurate early diagnosis. EVs, as mediators of intercellular communication, carry DNA, RNA, and proteins that show differential but not tumor-specific expression patterns in pancreatic cancer. Studies have shown that combining RNA markers in EVs (such as miRNA, circRNA, and lncRNA) with serum CA 19-9 testing can significantly enhance diagnostic accuracy for pancreatic cancer. EV-associated proteins have exhibited favorable diagnostic performance in early-stage pancreatic cancer in preliminary studies, though their clinical applicability remains to be further validated. Furthermore, mutations in KRAS, TP53, and SMAD4 genes within EVs offer a promising avenue for non-invasive liquid biopsy. However, challenges such as standardization, low sensitivity, and specificity still hinder the clinical application of EVs. Future research should focus on strategies including multi-omics integration, AI-assisted analysis, multi-marker combined detection, and large-scale clinical validation to further improve the diagnostic capability for pancreatic cancer. Overcoming these obstacles may position EVs as a vital tool in the diagnosis of pancreatic cancer. |
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| ISSN: | 2047-783X |