Walking recovers cartilage compressive strain in vivo
Background: Articular cartilage is a fiber reinforced hydrated solid that serves a largely mechanical role of supporting load and enabling low friction joint articulation. Daily activities that load cartilage, lead to fluid exudation and compressive axial strain. To date, the only mechanism shown to...
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| Format: | Article |
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Elsevier
2024-12-01
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| Series: | Osteoarthritis and Cartilage Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665913124000931 |
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| author | Shu-Jin Kust Kyle D. Meadows Dana Voinier JiYeon A. Hong Dawn M. Elliott Daniel K. White Axel C. Moore |
| author_facet | Shu-Jin Kust Kyle D. Meadows Dana Voinier JiYeon A. Hong Dawn M. Elliott Daniel K. White Axel C. Moore |
| author_sort | Shu-Jin Kust |
| collection | DOAJ |
| description | Background: Articular cartilage is a fiber reinforced hydrated solid that serves a largely mechanical role of supporting load and enabling low friction joint articulation. Daily activities that load cartilage, lead to fluid exudation and compressive axial strain. To date, the only mechanism shown to recover this cartilage strain in vivo is unloading (e.g., lying supine). Based on recent work in cartilage explants, we hypothesized that loaded joint activity (walking) would also be capable of strain recovery in cartilage. Methods: Eight asymptomatic young adults performed a fixed series of tasks, each of which was followed by magnetic resonance imaging to track changes in their knee cartilage thickness. The order of tasks was as follows: 1) stand for 30 min, 2) walk for 10 min, 3) stand for 30 min, and 4) lie supine for 50 min. The change in cartilage thickness was used to compute the axial cartilage strain. Results: Standing produced an average axial strain of −5.1 % (compressive) in the tibiofemoral knee cartilage, while lying supine led to strain recovery. In agreement with our hypothesis, walking also led to cartilage strain recovery. Interestingly, the recovery rate during walking (0.19 % strain/min) was nearly 3-fold faster than lying supine (0.07 % strain/min). Conclusions: This study represents the first in vivo demonstration that joint activity is capable of recovering compressive strain in cartilage. These findings indicate that joint activities such as walking may play a key role in maintaining and recovering cartilage strain, with implications for maintaining cartilage health and preventing or delaying cartilage degeneration. |
| format | Article |
| id | doaj-art-463fc7233e0640779498ba043abe8260 |
| institution | DOAJ |
| issn | 2665-9131 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Osteoarthritis and Cartilage Open |
| spelling | doaj-art-463fc7233e0640779498ba043abe82602025-08-20T02:48:39ZengElsevierOsteoarthritis and Cartilage Open2665-91312024-12-016410052610.1016/j.ocarto.2024.100526Walking recovers cartilage compressive strain in vivoShu-Jin Kust0Kyle D. Meadows1Dana Voinier2JiYeon A. Hong3Dawn M. Elliott4Daniel K. White5Axel C. Moore6Department of Biomedical Engineering, University of Delaware, Newark, DE, USADepartment of Biomedical Engineering, University of Delaware, Newark, DE, USADepartment of Physical Therapy, University of Delaware, Newark, DE, USADepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USADepartment of Biomedical Engineering, University of Delaware, Newark, DE, USADepartment of Physical Therapy, University of Delaware, Newark, DE, USADepartment of Biomedical Engineering, University of Delaware, Newark, DE, USA; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA; Corresponding author. Carnegie Mellon University, 5000 Forbes Avenue, Scott Hall, 4N205, Pittsburgh, PA 15213, USA.Background: Articular cartilage is a fiber reinforced hydrated solid that serves a largely mechanical role of supporting load and enabling low friction joint articulation. Daily activities that load cartilage, lead to fluid exudation and compressive axial strain. To date, the only mechanism shown to recover this cartilage strain in vivo is unloading (e.g., lying supine). Based on recent work in cartilage explants, we hypothesized that loaded joint activity (walking) would also be capable of strain recovery in cartilage. Methods: Eight asymptomatic young adults performed a fixed series of tasks, each of which was followed by magnetic resonance imaging to track changes in their knee cartilage thickness. The order of tasks was as follows: 1) stand for 30 min, 2) walk for 10 min, 3) stand for 30 min, and 4) lie supine for 50 min. The change in cartilage thickness was used to compute the axial cartilage strain. Results: Standing produced an average axial strain of −5.1 % (compressive) in the tibiofemoral knee cartilage, while lying supine led to strain recovery. In agreement with our hypothesis, walking also led to cartilage strain recovery. Interestingly, the recovery rate during walking (0.19 % strain/min) was nearly 3-fold faster than lying supine (0.07 % strain/min). Conclusions: This study represents the first in vivo demonstration that joint activity is capable of recovering compressive strain in cartilage. These findings indicate that joint activities such as walking may play a key role in maintaining and recovering cartilage strain, with implications for maintaining cartilage health and preventing or delaying cartilage degeneration.http://www.sciencedirect.com/science/article/pii/S2665913124000931Articular cartilageCartilage strainJoint space widthMagnetic resonance imagingWalkingStanding |
| spellingShingle | Shu-Jin Kust Kyle D. Meadows Dana Voinier JiYeon A. Hong Dawn M. Elliott Daniel K. White Axel C. Moore Walking recovers cartilage compressive strain in vivo Osteoarthritis and Cartilage Open Articular cartilage Cartilage strain Joint space width Magnetic resonance imaging Walking Standing |
| title | Walking recovers cartilage compressive strain in vivo |
| title_full | Walking recovers cartilage compressive strain in vivo |
| title_fullStr | Walking recovers cartilage compressive strain in vivo |
| title_full_unstemmed | Walking recovers cartilage compressive strain in vivo |
| title_short | Walking recovers cartilage compressive strain in vivo |
| title_sort | walking recovers cartilage compressive strain in vivo |
| topic | Articular cartilage Cartilage strain Joint space width Magnetic resonance imaging Walking Standing |
| url | http://www.sciencedirect.com/science/article/pii/S2665913124000931 |
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